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Gene · 148

ADRA1A: adrenoceptor alpha 1A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADRA1A: adrenoceptor alpha 1A. Genes, record 148. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/148

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Gene

Symbol
ADRA1A
HGNC
Name
adrenoceptor alpha 1A
HGNC
NCBI Gene ID
148
NCBI Gene
HGNC ID
HGNC:277
HGNC
Ensembl
ENSG00000120907
NCBI Gene
Aliases
ADRA1C, ADRA1L1, ALPHA1AAR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35348Alpha-1A adrenergic receptor4669Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436834P35348Espacenet
JP 2026004568 A2026-01-1436838P35348Espacenet
EP 4641201 A22025-10-292538P35348Espacenet
JP 2025529142 A2025-09-04331P35348Espacenet
US 12371689 B22025-07-29331P35348Espacenet
JP 2025517969 A2025-06-122538P35348Espacenet
JP 2025062604 A2025-04-143456P35348Espacenet
JP 2025062604 A2025-04-143459P35348Espacenet
JP 2025032204 A2025-03-1124236P35348Espacenet
JP 2025032204 A2025-03-1124237P35348Espacenet

1 to 10 of 58

See all 58 patents

Drugs75

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALFUZOSINCHEMBL709Adrenergic receptor alpha-1 agonistAGONISTChEMBL
ALFUZOSIN HYDROCHLORIDECHEMBL1723Adrenergic receptor alpha-1 agonistAGONISTChEMBL
ALSEROXYLONCHEMBL1201454Adrenergic receptor alpha antagonistANTAGONISTChEMBL
AVIPTADILCHEMBL1981592Adrenergic receptor alpha antagonistANTAGONISTChEMBL
BUCINDOLOLCHEMBL321582Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
BUCINDOLOL HYDROCHLORIDECHEMBL2107546Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
BUNAZOSINCHEMBL188185Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
CARVEDILOLCHEMBL723Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
CARVEDILOL PHOSPHATECHEMBL1201167Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
DABUZALGRONCHEMBL257978Alpha-1a adrenergic receptor partial agonistPARTIAL AGONISTChEMBL

1 to 10 of 75

See all 75 drugs

Trials775

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,058

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADRA1A papersNewest fiscal year
I01BX000740Right Heart Function in Health and Chronic Disease32025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions32025
P30CA016672Cancer Center Support Grant32025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal32025
R01HL140067Metabolic mechanisms of cardioprotection through alpha-1A adrenergic receptor activation32025
T32GM007569Clinical Pharmacology Training Program32025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)32025
P30AG066508Yale Alzheimer Disease Research Center22025
P30CA068485Cancer Center Support Grant22025
P30DK026687New York Obesity Research Center22025

1 to 10 of 1,058Source NIH's project files

See all 1,058 nih grants

Papers1,657

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Construction of α1A-Adrenoceptor-Based Stationary Phase Triggered by the Ultrahigh Affinity Protein Pair Colicin E7 Dnase /IM7 for Targeted Bioactive Compound Screening in Herba leonuri.J Sep Sci202642703902PubTator, text miningPubMed
ASIV Attenuates Cisplatin-Induced Proximal Tubular Injury by Enhancing Mitochondrial Biogenesis and Mitophagy Through the ADRA1A/AMPK/FOXO3A Pathway.FASEB J202642687819PubTator, text miningPubMed
α 1A-Adrenergic receptor (ADRA1A) signaling signatures as prognostic biomarkers in liver hepatocellular carcinoma: a bioinformatic analysis.In Silico Pharmacol202642542688PubTator, text miningPubMed
RORα-Adra1a: defining a new transcriptional axis in cardiomyocyte biology.Am J Physiol Heart Circ Physiol202642531559PubTator, text miningPubMed
Increased Adrenergic Receptor Expression in Meniere Disease.Otol Neurotol202642531530PubTator, text miningPubMed
Aconitine from Aconiti Lateralis Radix Praeparata (Fuzi) Suppresses Intrahepatic Cholangiocarcinoma via TOP2A: A Study Combining Machine Learning with Functional Validation.Chin J Integr Med202642448944PubTator, text miningPubMed
Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain.Cell Rep202642241279PubTator, text miningPubMed
G protein-coupled receptor autoantibody expression patterns in adults with decelerated biological aging mirror pediatric profiles.BMC Immunol202642237231PubTator, text miningPubMed
Neuroimmunological Mechanisms of Xiao-Yao-San Against Chronic Stress-Induced Colorectal Cancer: A Bioinformatics and Single-Cell Sequencing Study.Cancer Manag Res202641798904PubTator, text miningPubMed
Studies and analysis of drug-target interactions by affinity chromatography and related techniques: A review.J Pharm Anal202641798072PubTator, text miningPubMed

1 to 10 of 1,657

See all 1,657 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/148

GET https://conductscience.org/api/genes/v1/148/patents?page=2