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NKX2-5: NK2 homeobox 5

1 protein, 52 patents, 0 drugs, 0 trials, 3,211 NIH grants and 4,783 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNKX2-5HGNC
NameNK2 homeobox 5HGNC
NCBI Gene ID1482NCBI Gene
HGNC IDHGNC:2488HGNC
EnsemblENSG00000183072NCBI Gene
AliasesCHNG5, CSX, CSX1, HLHS2, NKX2.5, NKX2E, NKX4-1, VSD3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P52952Homeobox protein Nkx-2.53244Ensembl, GeneID, HGNCUniProt

Patents 52

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455808P52952Espacenet
EP 4641201 A22025-10-295392P52952Espacenet
JP 2025147176 A2025-10-0615396P52952Espacenet
JP 2025517969 A2025-06-125392P52952Espacenet
JP 2025028160 A2025-02-2815396P52952Espacenet
KR 1020250010750 A2025-01-2115396P52952Espacenet
JP 2024128028 A2024-09-2031P52952Espacenet
JP 2024109657 A2024-08-1415235P52952Espacenet
US 12024722 B22024-07-02273P52952Espacenet
US 11760977 B22023-09-1931P52952Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3211

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling162,025NIH's project files
R01HL057181Cardiogenesis: Molecular Mechanisms132,025NIH's project files
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL122,025NIH's project files
T32HL007208Integrated, Multidisciplinary Training in Cardiovascular Research122,025NIH's project files
R01HL130020Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs112,025NIH's project files
R01HL076485Engineering Vascularized Cardiac Muscle102,025NIH's project files
P30CA016672Cancer Center Support Grant92,025NIH's project files
T32EB009035Multi-Disciplinary Training Program in Cardiovascular Imaging at Stanford92,025NIH's project files
P30DK063491Diabetes Research Center (DRC)82,025NIH's project files
T32HL007572Research Methods in Pediatric Cardiovascular Disease82,025NIH's project files

Papers 4783

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42798645PubTator, text miningPubMed
42792731PubTator, text miningPubMed
42780136PubTator, text miningPubMed
42677697PubTator, text miningPubMed
42644057PubTator, text miningPubMed
42626645PubTator, text miningPubMed
42598495PubTator, text miningPubMed
42565819PubTator, text miningPubMed
42481704PubTator, text miningPubMed
42437293PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license