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Gene · 1487

CTBP1: C-terminal binding protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CTBP1: C-terminal binding protein 1. Genes, record 1487. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1487

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Gene

Symbol
CTBP1
HGNC
Name
C-terminal binding protein 1
HGNC
NCBI Gene ID
1487
NCBI Gene
HGNC ID
HGNC:2494
HGNC
Ensembl
ENSG00000159692
NCBI Gene
Aliases
BARS, HADDTS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13363C-terminal-binding protein 144011Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12540940 B22026-02-0329Q13363Espacenet
EP 4641201 A22025-10-293032Q13363Espacenet
JP 2025517969 A2025-06-123032Q13363Espacenet
EP 4463571 A12024-11-20202Q13363Espacenet
JP 2024123008 A2024-09-105678Q13363Espacenet
JP 2024509935 A2024-03-0599Q13363Espacenet
JP 2024507735 A2024-02-21120Q13363Espacenet
JP 2024506869 A2024-02-1588Q13363Espacenet
JP 2024506869 A2024-02-1589Q13363Espacenet
JP 2024501437 A2024-01-1263Q13363Espacenet

1 to 10 of 48

See all 48 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,062

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCTBP1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant112025
R01HL056687Mechanisms of Maladaptation in Heart Failure102025
R01AG055357Dysregulation of Cav1.2 by beta amyloid peptide72025
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors62025
P30CA008748Cancer Center Support Grant52025
P30CA016059Massey Cancer Center - Cancer Center Support Grant52025
P42ES010356Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation52025
R01DK073368Mechanisms of Compartmentalized cAMP Signaling52025
R35GM133521Investigation of a Newly Discovered Organelle-Based Signaling Paradigm52025
R37GM058615Mechanisms and Physiology of COPI Transport52025

1 to 10 of 2,062Source NIH's project files

See all 2,062 nih grants

Papers2,891

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Synergistic Variants in C-terminal Binding Protein 1 and Alkaline Phosphatase Lead to Mandibular Hypoplasia Through Impaired Wnt Signaling: An Oligogenic Model.bioRxiv202642780217PubTator, text miningPubMed
Floppy baby syndrome as the first presentation of HADDTS associated with CTBP1 mutation.Folia Neuropathol202642704868PubTator, text miningPubMed
Beyond β-Adrenergic Receptor Brake: Compartment-Selective GRK2 Programs from Heart Failure to Cardio-Oncology.Kinases Phosphatases202642614945PubTator, text miningPubMed
ZEB2 SUMOylation in Cardiac Fibroblast Drives Post-Infarction Cardiac Remodeling through CtBP1-Associated repression of Nr4a1.iScience202642602983PubTator, text miningPubMed
Delineating the CTBP1-Related Phenotypic Spectrum: A Review of HADDTS and Atypical Variants.Int J Mol Sci202642589715PubTator, text miningPubMed
Targeting the CTBP1-CETP axis overcomes ferroptosis resistance in non-small cell lung cancer by altering lipid accumulation.Clin Transl Med202642515937PubTator, text miningPubMed
Molecular mechanism of CtBP1-S/BARS-driven membrane fission and its cellular control by metabolic ligands.Sci Adv202642497255PubTator, text miningPubMed
Methylation patterns linked to blood pressure in people with HIV exposed to antiretroviral therapy reveal neurovascular and immune pathways.AIDS202642440125PubTator, text miningPubMed
Downregulation of long non-coding RNAs PCAT18, HOTAIR, and CTBP1-AS in prostate malignancies.Mol Biol Rep202642313281PubTator, text miningPubMed
A Rare CTBP1-Related Neurodevelopmental Disorder Is Associated with Impaired Mitochondrial Bioenergetics: A Functional Case Report.Int J Mol Sci202642123581PubTator, text miningPubMed

1 to 10 of 2,891

See all 2,891 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1487

GET https://conductscience.org/api/genes/v1/1487/patents?page=2