ConductScience.org, home

Library / Genes

CCN2: cellular communication network factor 2

1 protein, 62 patents, 1 drug, 19 trials, 6,423 NIH grants and 14,905 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCCN2HGNC
Namecellular communication network factor 2HGNC
NCBI Gene ID1490NCBI Gene
HGNC IDHGNC:2500HGNC
EnsemblENSG00000118523NCBI Gene
AliasesCTGF, HCS24, IBP-8, IGFBP8, KMD, NOV2, SEMDLSLNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29279CCN family member 23490Ensembl, GeneID, HGNCUniProt

Patents 62

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12600770 B22026-04-141P29279Espacenet
WO 2026017877 A12026-01-228P29279Espacenet
EP 4650780 A22025-11-198337P29279Espacenet
WO 2025225410 A2025-10-301P29279Espacenet
EP 4641201 A22025-10-298528P29279Espacenet
JP 2025147176 A2025-10-063663P29279Espacenet
JP 2025529142 A2025-09-046045P29279Espacenet
WO 2025181215 A12025-09-041P29279Espacenet
US 12371689 B22025-07-296045P29279Espacenet
JP 2025517969 A2025-06-128528P29279Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PAMREVLUMABCHEMBL2109377Connective tissue growth factor inhibitorINHIBITORChEMBL

Trials 19

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05262309PAMREVLUMABPHASE2/PHASE3ClinicalTrials.gov
NCT04632940PAMREVLUMABPHASE32024-08-26ClinicalTrials.gov
NCT04432298PAMREVLUMABPHASE22022-07-18ClinicalTrials.gov
NCT04419558PAMREVLUMABPHASE32024-08-12ClinicalTrials.gov
NCT04371666PAMREVLUMABPHASE32024-03-12ClinicalTrials.gov
NCT03955146PAMREVLUMABPHASE32024-09-19ClinicalTrials.gov
NCT03941093PAMREVLUMABPHASE32024-11-05ClinicalTrials.gov
NCT02851381PAMREVLUMABClinicalTrials.gov
NCT02606136PAMREVLUMABPHASE22021-12-30ClinicalTrials.gov
NCT02210559PAMREVLUMABPHASE1/PHASE22023-03-02ClinicalTrials.gov

NIH grants 6423

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant592,025NIH's project files
P30CA008748Cancer Center Support Grant372,025NIH's project files
P30DK084567Mayo Center for Cell Signaling in Gastroenterology192,025NIH's project files
K24AR060297Scleroderma Twin Study and analysis of Estrogen in patients with dcSSc162,025NIH's project files
P30DK026743UCSF Liver Center152,025NIH's project files
P30EY005722Center Core Grant for Vision Research152,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award152,025NIH's project files
P30CA016058Cancer Center Support Grant142,025NIH's project files
P30CA068485Cancer Center Support Grant142,025NIH's project files
R01HL076246Chemokines in healing myocardial infarction132,025NIH's project files

Papers 14905

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818031PubTator, text miningPubMed
42784458PubTator, text miningPubMed
42774705PubTator, text miningPubMed
42770147PubTator, text miningPubMed
42766934PubTator, text miningPubMed
42764425PubTator, text miningPubMed
42760160PubTator, text miningPubMed
42749952PubTator, text miningPubMed
42749005PubTator, text miningPubMed
42728239PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license