Gene · 1491
CTH: cystathionine gamma-lyase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CTH: cystathionine gamma-lyase. Genes, record 1491. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1491
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P32929 | Cystathionine gamma-lyase | 405 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents71
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 42679 | P32929 | Espacenet |
| EP 4658689 A2 | 2025-12-10 | 1 | P32929 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8865 | P32929 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 9090 | P32929 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 5499 | P32929 | Espacenet |
| JP 2025111469 A | 2025-07-30 | 1 | P32929 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 9090 | P32929 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8865 | P32929 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 26920 | P32929 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 5499 | P32929 | Espacenet |
1 to 10 of 71
See all 71 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,059
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CTH papers | Newest fiscal year |
|---|---|---|---|
| P20GM121307 | Center for Redox Biology and Cardiovascular Disease | 17 | 2025 |
| R01HL070562 | Actions of Estrogen on Uterine Artery Endothelium | 13 | 2025 |
| R35GM130183 | Sulfide metabolism and signaling | 9 | 2025 |
| P30DK056350 | Nutrition Obesity Research Center (NORC) | 4 | 2025 |
| ZIACP010121 | Molecular Epidemiology Studies of Occupational and Environmental Exposures | 4 | 2025 |
| P01CA116087 | H. pylori-induced Inflammation and Gastric Cancer | 3 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,059Source NIH's project files
See all 1,059 nih grantsPapers3,417
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Statement of Retraction: IFC-305 attenuates renal ischemia-reperfusion injury by promoting the production of hydrogen sulfide (H2S) via suppressing the promoter methylation of cystathionine γ-lyase (CSE). | Bioengineered | 2026 | 42821370 | PubTator, text mining | PubMed |
The Association Between Hyperketonemia and Reduced Circulating Hydrogen Sulfide in Children with Type 1 Diabetes, and Ketone Inhibition of Cystathionine-γ-Lyase mRNA Expression in Cultured Hepatocytes. | Genes (Basel) | 2026 | 42792984 | PubTator, text mining | PubMed |
| Helicobacter pylori-induced cystathionine-γ-lyase drives redox imbalance and metabolic remodeling in gastric cancer. | J Gastrointest Oncol | 2026 | 42703474 | PubTator, text mining | PubMed |
| Nitric oxide and hydrogen sulfide signaling pathways are involved in benign prostatic hyperplasia: pathophysiological development and novel therapeutic strategies. | Med Gas Res | 2026 | 42671404 | PubTator, text mining | PubMed |
| Epstein-Barr virus transformation creates a methionine-dependent ferroptosis vulnerability in B cells. | bioRxiv | 2026 | 42523280 | PubTator, text mining | PubMed |
| Periplasmic FeS Electron Conduits: Tuning Electrocoupling and Respiratory Dehalogenation in a Synthetic Consortium. | Angew Chem Int Ed Engl | 2026 | 42520180 | PubTator, text mining | PubMed |
| Exploratory profiling of oxidative stress and hydrogen sulfide synthesis gene expression and sequence variants in gastric cancer patients. | Mol Biol Rep | 2026 | 42507218 | PubTator, text mining | PubMed |
| A targetable FTO/SLC7A11/CBS/CTH axis controls cysteine metabolism, growth and survival in NSCLC. | Sci Adv | 2026 | 42397900 | PubTator, text mining | PubMed |
| The potential role of H2S in the anti-infective function of antimicrobial peptides. | Nat Commun | 2026 | 42386743 | PubTator, text mining | PubMed |
| Redox Network Failure in Chronic Kidney Disease: Hydrogen Sulfide Deficiency, Reactive Sulfur Species Dysregulation and the Uremic Toxin-AhR-Mitochondrial Axis. | Antioxidants (Basel) | 2026 | 42352052 | PubTator, text mining | PubMed |
1 to 10 of 3,417
See all 3,417 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1491
GET https://conductscience.org/api/genes/v1/1491/patents?page=2