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Gene · 1491

CTH: cystathionine gamma-lyase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CTH: cystathionine gamma-lyase. Genes, record 1491. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1491

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Gene

Symbol
CTH
HGNC
Name
cystathionine gamma-lyase
HGNC
NCBI Gene ID
1491
NCBI Gene
HGNC ID
HGNC:2501
HGNC
Ensembl
ENSG00000116761
NCBI Gene
Aliases
CGL, CSE
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P32929Cystathionine gamma-lyase4059Ensembl, GeneID, HGNC

Source UniProt

Patents71

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442679P32929Espacenet
EP 4658689 A22025-12-101P32929Espacenet
EP 4650780 A22025-11-198865P32929Espacenet
EP 4641201 A22025-10-299090P32929Espacenet
EP 4641202 A22025-10-295499P32929Espacenet
JP 2025111469 A2025-07-301P32929Espacenet
JP 2025517969 A2025-06-129090P32929Espacenet
JP 2025517970 A2025-06-128865P32929Espacenet
JP 2025032204 A2025-03-1126920P32929Espacenet
KR 1020250017231 A2025-02-045499P32929Espacenet

1 to 10 of 71

See all 71 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,059

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCTH papersNewest fiscal year
P20GM121307Center for Redox Biology and Cardiovascular Disease172025
R01HL070562Actions of Estrogen on Uterine Artery Endothelium132025
R35GM130183Sulfide metabolism and signaling92025
P30DK056350Nutrition Obesity Research Center (NORC)42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer32025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA008748Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025

1 to 10 of 1,059Source NIH's project files

See all 1,059 nih grants

Papers3,417

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Statement of Retraction: IFC-305 attenuates renal ischemia-reperfusion injury by promoting the production of hydrogen sulfide (H2S) via suppressing the promoter methylation of cystathionine γ-lyase (CSE).
Bioengineered202642821370PubTator, text miningPubMed
The Association Between Hyperketonemia and Reduced Circulating Hydrogen Sulfide in Children with Type 1 Diabetes, and Ketone Inhibition of Cystathionine-γ-Lyase mRNA Expression in Cultured Hepatocytes.
Genes (Basel)202642792984PubTator, text miningPubMed
Helicobacter pylori-induced cystathionine-γ-lyase drives redox imbalance and metabolic remodeling in gastric cancer.J Gastrointest Oncol202642703474PubTator, text miningPubMed
Nitric oxide and hydrogen sulfide signaling pathways are involved in benign prostatic hyperplasia: pathophysiological development and novel therapeutic strategies.Med Gas Res202642671404PubTator, text miningPubMed
Epstein-Barr virus transformation creates a methionine-dependent ferroptosis vulnerability in B cells.bioRxiv202642523280PubTator, text miningPubMed
Periplasmic FeS Electron Conduits: Tuning Electrocoupling and Respiratory Dehalogenation in a Synthetic Consortium.Angew Chem Int Ed Engl202642520180PubTator, text miningPubMed
Exploratory profiling of oxidative stress and hydrogen sulfide synthesis gene expression and sequence variants in gastric cancer patients.Mol Biol Rep202642507218PubTator, text miningPubMed
A targetable FTO/SLC7A11/CBS/CTH axis controls cysteine metabolism, growth and survival in NSCLC.Sci Adv202642397900PubTator, text miningPubMed
The potential role of H2S in the anti-infective function of antimicrobial peptides.Nat Commun202642386743PubTator, text miningPubMed
Redox Network Failure in Chronic Kidney Disease: Hydrogen Sulfide Deficiency, Reactive Sulfur Species Dysregulation and the Uremic Toxin-AhR-Mitochondrial Axis.Antioxidants (Basel)202642352052PubTator, text miningPubMed

1 to 10 of 3,417

See all 3,417 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1491

GET https://conductscience.org/api/genes/v1/1491/patents?page=2