ConductScience.org, home

Library / Genes

CTLA4: cytotoxic T-lymphocyte associated protein 4

1 protein, 639 patents, 6 drugs, 1,206 trials, 14,782 NIH grants and 60,841 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCTLA4HGNC
Namecytotoxic T-lymphocyte associated protein 4HGNC
NCBI Gene ID1493NCBI Gene
HGNC IDHGNC:2505HGNC
EnsemblENSG00000163599NCBI Gene
AliasesALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P16410Cytotoxic T-lymphocyte protein 422322Ensembl, GeneID, HGNCUniProt

Patents 639

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4831196 A22026-10-289P16410Espacenet
EP 4824105 A12026-10-21437P16410Espacenet
EP 4808571 A12026-09-237P16410Espacenet
EP 4806462 A22026-09-1634P16410Espacenet
WO 2026171881 A12026-08-2017P16410Espacenet
JP 2026120541 A2026-07-2290P16410Espacenet
JP 2026102780 A2026-06-231P16410Espacenet
EP 4755457 A22026-06-10214P16410Espacenet
JP 2026082857 A2026-05-1990P16410Espacenet
US 12630648 B22026-05-19149P16410Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CADONILIMABCHEMBL4594456Cytotoxic T-lymphocyte protein 4 inhibitorINHIBITORChEMBL
ERFONRILIMABCHEMBL4650483Cytotoxic T-lymphocyte protein 4 inhibitorINHIBITORChEMBL
IPILIMUMABCHEMBL1789844Cytotoxic T-lymphocyte protein 4 inhibitorINHIBITORChEMBL
QUAVONLIMABCHEMBL4650419Cytotoxic T-lymphocyte protein 4 inhibitorINHIBITORChEMBL
TREMELIMUMABCHEMBL2108658Cytotoxic T-lymphocyte protein 4 inhibitorINHIBITORChEMBL
ZALIFRELIMABCHEMBL4297876Cytotoxic T-lymphocyte protein 4 inhibitorINHIBITORChEMBL

Trials 1206

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07607769TREMELIMUMABClinicalTrials.gov
NCT07603856IPILIMUMABPHASE2ClinicalTrials.gov
NCT07587827IPILIMUMABPHASE1ClinicalTrials.gov
NCT07586904CADONILIMABEARLY_PHASE1ClinicalTrials.gov
NCT07560488IPILIMUMABPHASE2ClinicalTrials.gov
NCT07556640CADONILIMABPHASE2ClinicalTrials.gov
NCT07544784CADONILIMABPHASE2ClinicalTrials.gov
NCT07526961IPILIMUMABClinicalTrials.gov
NCT07511504TREMELIMUMABPHASE2ClinicalTrials.gov
NCT07511036IPILIMUMABPHASE2ClinicalTrials.gov

NIH grants 14782

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant7502,025NIH's project files
P30CA016672Cancer Center Support Grant5092,025NIH's project files
P30CA006973Regional Oncology Research Center1862,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award1572,025NIH's project files
P30CA047904Cancer Center Support Grant1222,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant1012,025NIH's project files
P30CA016058Cancer Center Support Grant812,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program782,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant742,025NIH's project files
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)702,025NIH's project files

Papers 60841

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826489PubTator, text miningPubMed
42824772PubTator, text miningPubMed
42824677PubTator, text miningPubMed
42820658PubTator, text miningPubMed
42820287PubTator, text miningPubMed
42819059PubTator, text miningPubMed
42816994PubTator, text miningPubMed
42816192PubTator, text miningPubMed
42815983PubTator, text miningPubMed
42814321PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license