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Gene · 150

ADRA2A: adrenoceptor alpha 2A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADRA2A: adrenoceptor alpha 2A. Genes, record 150. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/150

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Gene

Symbol
ADRA2A
HGNC
Name
adrenoceptor alpha 2A
HGNC
NCBI Gene ID
150
NCBI Gene
HGNC ID
HGNC:281
HGNC
Ensembl
ENSG00000150594
NCBI Gene
Aliases
ADRA2, ADRA2R, ADRAR, ALPHA2AAR, FPLD8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08913Alpha-2A adrenergic receptor46519Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-292631P08913Espacenet
JP 2025529142 A2025-09-04334P08913Espacenet
US 12371689 B22025-07-29334P08913Espacenet
JP 2025517969 A2025-06-122631P08913Espacenet
JP 2025062604 A2025-04-143467P08913Espacenet
WO 2024251866 A12024-12-1228P08913Espacenet
EP 4426287 A12024-09-111P08913Espacenet
JP 2024123008 A2024-09-104791P08913Espacenet
US 11446398 B22022-09-203467P08913Espacenet
US 11400116 B22022-08-02196P08913Espacenet

1 to 10 of 26

See all 26 patents

Drugs66

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALSEROXYLONCHEMBL1201454Adrenergic receptor alpha antagonistANTAGONISTChEMBL
APRACLONIDINECHEMBL647Adrenergic receptor alpha-2 agonistAGONISTChEMBL
APRACLONIDINE HYDROCHLORIDECHEMBL1200379Adrenergic receptor alpha-2 agonistAGONISTChEMBL
AVIPTADILCHEMBL1981592Adrenergic receptor alpha antagonistANTAGONISTChEMBL
BRIMONIDINECHEMBL844Adrenergic receptor alpha-2 agonistAGONISTChEMBL
BRIMONIDINE TARTRATECHEMBL1200389Adrenergic receptor alpha-2 agonistAGONISTChEMBL
CELIPROLOLCHEMBL27810Adrenergic receptor alpha-2 antagonistANTAGONISTChEMBL
CLONIDINECHEMBL134Adrenergic receptor alpha-2 agonistAGONISTChEMBL
CLONIDINE HYDROCHLORIDECHEMBL1705Adrenergic receptor alpha-2 agonistAGONISTChEMBL
DEXMEDETOMIDINECHEMBL778Adrenergic receptor alpha-2 agonistAGONISTChEMBL

1 to 10 of 66

See all 66 drugs

Trials1,036

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603596DEXMEDETOMIDINEPHASE1ClinicalTrials.gov
NCT07585201DEXMEDETOMIDINEClinicalTrials.gov
NCT07573969DEXMEDETOMIDINEPHASE3ClinicalTrials.gov
NCT07572656LABETALOLClinicalTrials.gov
NCT07569536DEXMEDETOMIDINEPHASE3ClinicalTrials.gov
NCT07564531DEXMEDETOMIDINEClinicalTrials.gov
NCT07557680DEXMEDETOMIDINEPHASE3ClinicalTrials.gov
NCT07542990DEXMEDETOMIDINEPHASE3ClinicalTrials.gov
NCT07537894DEXMEDETOMIDINEPHASE2/PHASE3ClinicalTrials.gov
NCT07532733DEXMEDETOMIDINEClinicalTrials.gov

1 to 10 of 1,036

See all 1,036 trials

NIH grants1,882

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADRA2A papersNewest fiscal year
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors82025
P30DK020572Michigan Diabetes Research Center (MDRC)62025
P30CA068485Cancer Center Support Grant52025
P30DK063491Diabetes Research Center (DRC)52025
R01MH084894Function of GPCR heteromeric complexes in brain52025
ZIADA000493Functional and Pharmacological Significance of Receptor Heteromers in the CNS52025
P30CA016672Cancer Center Support Grant42025
P30DK058404Molecular and Cellular Basis for Digestive Diseases42025
R01DA008863Regulation Of Opioid Receptor Signaling by Endogenous Peptides42025
R01DK105448Genetic and Metabolic Basis of Familial Lipodystrophies42025

1 to 10 of 1,882Source NIH's project files

See all 1,882 nih grants

Papers2,435

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Conflicting Molecular Hallmarks of Lipedema Reflect Cell-Composition Confounding: A Reanalysis and Germline Reframing.Cureus202642824866PubTator, text miningPubMed
Guanfacine as a potential preventive therapy for chronic migraine: a mechanistic hypothesis.Front Neurol202642824170PubTator, text miningPubMed
Subtypes of Bladder-Innervating Sensory Neurons revealed by Immuno-Fluorescence In Situ Hybridization.bioRxiv202642818607PubTator, text miningPubMed
Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder.Front Mol Neurosci202642781299PubTator, text miningPubMed
In Silico and Molecular Docking Analysis of Benzyl Isothiocyanate from Salvadora persica as a Predicted Multi-Target Candidate for COVID-19 Host Responses.Curr Issues Mol Biol202642651847PubTator, text miningPubMed
TBX6 promotes proliferation, invasion, and migration in colorectal cancer: Integrated transcriptomic and protein interaction network analysis.Gene202642401341PubTator, text miningPubMed
Clinical Outcomes of Extended-Release Guanfacine in Adults With Attention-Deficit/Hyperactivity Disorder: A Retrospective Chart Review.Cureus202642388918PubTator, text miningPubMed
Novel Perspective for Prognostic Stratification and Personalized Therapy in Breast Cancer Patients: Development of Cancer Stem Cells and Metabolism-Associated Prognostic Model.Int J Womens Health202642358344PubTator, text miningPubMed
Sympathetic immunomodulation suppresses liver metastasis by maintaining the balance between norepinephrine concentration and the α2a/β2-AR ratio.Cell Mol Immunol202642332097PubTator, text miningPubMed
Deciphering the potential molecular network underlying nicotine- and its metabolite cotinine-induced myocardial infarction via network toxicology, molecular dynamics, and in vitro experimental validation.
Funct Integr Genomics202642319523PubTator, text miningPubMed

1 to 10 of 2,435

See all 2,435 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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