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CTSB: cathepsin B

1 protein, 480 patents, 0 drugs, 0 trials, 6,999 NIH grants and 16,020 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCTSBHGNC
Namecathepsin BHGNC
NCBI Gene ID1508NCBI Gene
HGNC IDHGNC:2527HGNC
EnsemblENSG00000164733NCBI Gene
AliasesAPPS, CPSB, KWE, RECEUPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P07858Cathepsin B33921Ensembl, GeneID, HGNCUniProt

Patents 480

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12570963 B22026-03-1035P07858Espacenet
US 12539325 B22026-02-0333P07858Espacenet
US 12516298 B22026-01-0635P07858Espacenet
EP 4662329 A12025-12-17323P07858Espacenet
EP 4662491 A22025-12-172607P07858Espacenet
EP 4650780 A22025-11-196704P07858Espacenet
JP 2025534299 A2025-10-1540P07858Espacenet
JP 2025147176 A2025-10-063717P07858Espacenet
JP 2025147176 A2025-10-063718P07858Espacenet
JP 2025147176 A2025-10-063719P07858Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 6999

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA022453CANCER CENTER SUPPORT GRANT312,025NIH's project files
P30CA008748Cancer Center Support Grant282,025NIH's project files
P30CA016672Cancer Center Support Grant202,025NIH's project files
P50AA011999Southern California Research Center for ALPD and Cirrhosis172,025NIH's project files
P01CA097132Sphingolipids in Cancer Biology and Therapy152,025NIH's project files
P30CA068485Cancer Center Support Grant132,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award132,025NIH's project files
P30CA036727Buffett Cancer Center Support Grant122,025NIH's project files
P30CA014051Cancer Center Support (Core) Grant112,025NIH's project files
P30EY005722Center Core Grant for Vision Research102,025NIH's project files

Papers 16020

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816199PubTator, text miningPubMed
42815330PubTator, text miningPubMed
42803978PubTator, text miningPubMed
42801629PubTator, text miningPubMed
42794827PubTator, text miningPubMed
42794678PubTator, text miningPubMed
42768898PubTator, text miningPubMed
42763893PubTator, text miningPubMed
42760737PubTator, text miningPubMed
42755525PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license