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ADRA2B: adrenoceptor alpha 2B

1 protein, 26 patents, 66 drugs, 1,036 trials, 6,345 NIH grants and 7,964 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolADRA2BHGNC
Nameadrenoceptor alpha 2BHGNC
NCBI Gene ID151NCBI Gene
HGNC IDHGNC:282HGNC
EnsemblENSG00000274286NCBI Gene
AliasesADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BARNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P18089Alpha-2B adrenergic receptor4502Ensembl, GeneID, HGNCUniProt

Patents 26

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1020P18089Espacenet
EP 4641201 A22025-10-2923051P18089Espacenet
JP 2025517969 A2025-06-1223051P18089Espacenet
JP 2025062604 A2025-04-143468P18089Espacenet
JP 2025032204 A2025-03-1124242P18089Espacenet
EP 4461818 A22024-11-1324242P18089Espacenet
JP 2023156353 A2023-10-2420P18089Espacenet
JP 2023058610 A2023-04-2524242P18089Espacenet
US 11446398 B22022-09-203468P18089Espacenet
US 11400116 B22022-08-02197P18089Espacenet

Drugs 66

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALSEROXYLONCHEMBL1201454Adrenergic receptor alpha antagonistANTAGONISTChEMBL
APRACLONIDINECHEMBL647Adrenergic receptor alpha-2 agonistAGONISTChEMBL
APRACLONIDINE HYDROCHLORIDECHEMBL1200379Adrenergic receptor alpha-2 agonistAGONISTChEMBL
AVIPTADILCHEMBL1981592Adrenergic receptor alpha antagonistANTAGONISTChEMBL
BRIMONIDINECHEMBL844Adrenergic receptor alpha-2 agonistAGONISTChEMBL
BRIMONIDINE TARTRATECHEMBL1200389Adrenergic receptor alpha-2 agonistAGONISTChEMBL
CELIPROLOLCHEMBL27810Adrenergic receptor alpha-2 antagonistANTAGONISTChEMBL
CLONIDINECHEMBL134Adrenergic receptor alpha-2 agonistAGONISTChEMBL
CLONIDINE HYDROCHLORIDECHEMBL1705Adrenergic receptor alpha-2 agonistAGONISTChEMBL
DEXMEDETOMIDINECHEMBL778Adrenergic receptor alpha-2 agonistAGONISTChEMBL

Trials 1036

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603596DEXMEDETOMIDINEPHASE1ClinicalTrials.gov
NCT07585201DEXMEDETOMIDINEClinicalTrials.gov
NCT07573969DEXMEDETOMIDINEPHASE3ClinicalTrials.gov
NCT07572656LABETALOLClinicalTrials.gov
NCT07569536DEXMEDETOMIDINEPHASE3ClinicalTrials.gov
NCT07564531DEXMEDETOMIDINEClinicalTrials.gov
NCT07557680DEXMEDETOMIDINEPHASE3ClinicalTrials.gov
NCT07542990DEXMEDETOMIDINEPHASE3ClinicalTrials.gov
NCT07537894DEXMEDETOMIDINEPHASE2/PHASE3ClinicalTrials.gov
NCT07532733DEXMEDETOMIDINEClinicalTrials.gov

NIH grants 6345

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL019278Platelet Integrin AlphaIIbBeta3 Structure, Activation, and Ligand Binding: Fibrinogen, Fibrin, D-dimer, and von Willebrand Factor232,025NIH's project files
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors222,025NIH's project files
P30CA016672Cancer Center Support Grant202,025NIH's project files
R01EY011500Structure-function studies of visual arrestin162,025NIH's project files
P30CA008748Cancer Center Support Grant152,025NIH's project files
ZIADK031117Development of Drugs Acting at Adenosine Receptors132,025NIH's project files
R01HL131836Structural Transition of Cellular Integrins and Applications Thereof122,025NIH's project files
ZIADK031126Computer Modeling of G Protein-Coupled Receptors102,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology92,025NIH's project files
R01HL102035Platelet-derived FVIII Gene Therapy of Hemophilia A82,025NIH's project files

Papers 7964

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824170PubTator, text miningPubMed
42547588PubTator, text miningPubMed
42502257PubTator, text miningPubMed
42465376PubTator, text miningPubMed
42463051PubTator, text miningPubMed
42403289PubTator, text miningPubMed
42331744PubTator, text miningPubMed
42330960PubTator, text miningPubMed
42292825PubTator, text miningPubMed
42286502PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license