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Gene · 1512

CTSH: cathepsin H

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CTSH: cathepsin H. Genes, record 1512. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1512

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Gene

Symbol
CTSH
HGNC
Name
cathepsin H
HGNC
NCBI Gene ID
1512
NCBI Gene
HGNC ID
HGNC:2535
HGNC
Ensembl
ENSG00000103811
NCBI Gene
Aliases
ACC-4, ACC-5, ACC4, ACC5, CPSB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P09668Pro-cathepsin H3352Ensembl, GeneID, HGNC

Source UniProt

Patents66

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0339P09668Espacenet
JP 2026004568 A2026-01-1440331P09668Espacenet
EP 4650780 A22025-11-19467P09668Espacenet
EP 4640849 A22025-10-2952P09668Espacenet
EP 4641201 A22025-10-29327P09668Espacenet
JP 2025147176 A2025-10-063751P09668Espacenet
JP 2025529142 A2025-09-046059P09668Espacenet
US 12371689 B22025-07-296059P09668Espacenet
JP 2025519096 A2025-06-2452P09668Espacenet
JP 2025517969 A2025-06-12327P09668Espacenet

1 to 10 of 66

See all 66 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,152

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCTSH papersNewest fiscal year
P30AG066444Alzheimer's Disease Research Center42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
I01BX003824Advanced conformational changes in NOTCH3 and cerebrovascular disease severity32025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study32025
P01AI042288Immune Function and the Progression to Type 1 Diabetes32025
P30AG066511Goizueta Alzheimer's Disease Research Center32025
P30CA008748Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
R01DK106191The CD226 costimulatory axis in type 1 diabetes32025
IK4BX005219BLR&D Research Career Development Transition Award Application22025

1 to 10 of 1,152Source NIH's project files

See all 1,152 nih grants

Papers1,642

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Causal effects of circulating cathepsins on cholecystitis, cholelithiasis, primary biliary cholangitis, primary sclerosing cholangitis, acute pancreatitis, and chronic pancreatitis: A Mendelian randomization study.
Medicine (Baltimore)202642760737PubTator, text miningPubMed
Genetic evidence for CTSH as a potential therapeutic target in sepsis: A Mendelian randomization and colocalization study.Medicine (Baltimore)202642760658PubTator, text miningPubMed
Multi-omics analysis identifies macrophage immunometabolic signatures in ulcerative colitis.Front Cell Infect Microbiol202642755516PubTator, text miningPubMed
Genetic and molecular evidence linking CTSH to Alzheimer's disease pathophysiology.Alzheimers Dement202642741981PubTator, text miningPubMed
Sex-specific associations of the plasma proteome with incident coronary artery disease.Cardiovasc Res202642687758PubTator, text miningPubMed
Free mitochondrial transfer enhances bone regeneration through cathepsin H mediated cysteine cycle.Cell Commun Signal202642449442PubTator, text miningPubMed
Occlusal types shape oral microbiome stomatotypes and metabolic landscapes: A multi-omics perspective on host-microbe interaction.Microb Cell202642389212PubTator, text miningPubMed
Cathepsin G Promotes Hepatic Lipid Deposition by Regulating Key Genes Related to Lipid Metabolism.FASEB J202641996208PubTator, text miningPubMed
Targeting LY6E Inhibits Neuroblastoma Progression and Suppresses M2 Macrophage Polarization.Hum Mutat202641993132PubTator, text miningPubMed
Unlocking caspase-8 enables Pt(IV) to trigger robust caspase-3/GSDME-mediated pyroptosis via drug co-delivery in chemoresistant bladder cancer.J Nanobiotechnology202641968294PubTator, text miningPubMed

1 to 10 of 1,642

See all 1,642 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1512

GET https://conductscience.org/api/genes/v1/1512/patents?page=2