Gene · 1512
CTSH: cathepsin H
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CTSH: cathepsin H. Genes, record 1512. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1512
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P09668 | Pro-cathepsin H | 335 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents66
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12539325 B2 | 2026-02-03 | 39 | P09668 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 40331 | P09668 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 467 | P09668 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 52 | P09668 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 327 | P09668 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 3751 | P09668 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6059 | P09668 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6059 | P09668 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 52 | P09668 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 327 | P09668 | Espacenet |
1 to 10 of 66
See all 66 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,152
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CTSH papers | Newest fiscal year |
|---|---|---|---|
| P30AG066444 | Alzheimer's Disease Research Center | 4 | 2025 |
| ZIACP010121 | Molecular Epidemiology Studies of Occupational and Environmental Exposures | 4 | 2025 |
| I01BX003824 | Advanced conformational changes in NOTCH3 and cerebrovascular disease severity | 3 | 2025 |
| P01AG026276 | Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study | 3 | 2025 |
| P01AI042288 | Immune Function and the Progression to Type 1 Diabetes | 3 | 2025 |
| P30AG066511 | Goizueta Alzheimer's Disease Research Center | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| R01DK106191 | The CD226 costimulatory axis in type 1 diabetes | 3 | 2025 |
| IK4BX005219 | BLR&D Research Career Development Transition Award Application | 2 | 2025 |
1 to 10 of 1,152Source NIH's project files
See all 1,152 nih grantsPapers1,642
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Causal effects of circulating cathepsins on cholecystitis, cholelithiasis, primary biliary cholangitis, primary sclerosing cholangitis, acute pancreatitis, and chronic pancreatitis: A Mendelian randomization study. | Medicine (Baltimore) | 2026 | 42760737 | PubTator, text mining | PubMed |
| Genetic evidence for CTSH as a potential therapeutic target in sepsis: A Mendelian randomization and colocalization study. | Medicine (Baltimore) | 2026 | 42760658 | PubTator, text mining | PubMed |
| Multi-omics analysis identifies macrophage immunometabolic signatures in ulcerative colitis. | Front Cell Infect Microbiol | 2026 | 42755516 | PubTator, text mining | PubMed |
| Genetic and molecular evidence linking CTSH to Alzheimer's disease pathophysiology. | Alzheimers Dement | 2026 | 42741981 | PubTator, text mining | PubMed |
| Sex-specific associations of the plasma proteome with incident coronary artery disease. | Cardiovasc Res | 2026 | 42687758 | PubTator, text mining | PubMed |
| Free mitochondrial transfer enhances bone regeneration through cathepsin H mediated cysteine cycle. | Cell Commun Signal | 2026 | 42449442 | PubTator, text mining | PubMed |
| Occlusal types shape oral microbiome stomatotypes and metabolic landscapes: A multi-omics perspective on host-microbe interaction. | Microb Cell | 2026 | 42389212 | PubTator, text mining | PubMed |
| Cathepsin G Promotes Hepatic Lipid Deposition by Regulating Key Genes Related to Lipid Metabolism. | FASEB J | 2026 | 41996208 | PubTator, text mining | PubMed |
| Targeting LY6E Inhibits Neuroblastoma Progression and Suppresses M2 Macrophage Polarization. | Hum Mutat | 2026 | 41993132 | PubTator, text mining | PubMed |
| Unlocking caspase-8 enables Pt(IV) to trigger robust caspase-3/GSDME-mediated pyroptosis via drug co-delivery in chemoresistant bladder cancer. | J Nanobiotechnology | 2026 | 41968294 | PubTator, text mining | PubMed |
1 to 10 of 1,642
See all 1,642 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1512
GET https://conductscience.org/api/genes/v1/1512/patents?page=2