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CTSK: cathepsin K

1 protein, 107 patents, 3 drugs, 14 trials, 2,233 NIH grants and 6,707 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCTSKHGNC
Namecathepsin KHGNC
NCBI Gene ID1513NCBI Gene
HGNC IDHGNC:2536HGNC
EnsemblENSG00000143387NCBI Gene
AliasesCTS02, CTSO, CTSO1, CTSO2, PKND, PYCDNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P43235Cathepsin K32970Ensembl, GeneID, HGNCUniProt

Patents 107

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21265P43235Espacenet
US 12539325 B22026-02-0340P43235Espacenet
JP 2026004568 A2026-01-1440334P43235Espacenet
EP 4650780 A22025-11-192785P43235Espacenet
EP 4641201 A22025-10-292350P43235Espacenet
JP 2025534299 A2025-10-1542P43235Espacenet
JP 2025147176 A2025-10-063756P43235Espacenet
WO 2025186446 A12025-09-1235P43235Espacenet
EP 4613860 A12025-09-1035P43235Espacenet
JP 2025529142 A2025-09-041148P43235Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BALICATIBCHEMBL371064Cathepsin K inhibitorINHIBITORChEMBL
ODANACATIBCHEMBL481611Cathepsin K inhibitorINHIBITORChEMBL
ONO-5334CHEMBL4802176Cathepsin K inhibitorINHIBITORChEMBL

Trials 14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01803607ODANACATIBPHASE32017-05-22ClinicalTrials.gov
NCT01552122ODANACATIBPHASE3ClinicalTrials.gov
NCT01384188ONO-5334PHASE1/PHASE2ClinicalTrials.gov
NCT01120600ODANACATIBPHASE32017-12-06ClinicalTrials.gov
NCT00885170ODANACATIBPHASE22017-04-18ClinicalTrials.gov
NCT00863525ODANACATIBPHASE1ClinicalTrials.gov
NCT00620113ODANACATIBPHASE22017-03-13ClinicalTrials.gov
NCT00532337ONO-5334PHASE2ClinicalTrials.gov
NCT00399802ODANACATIBPHASE22018-02-01ClinicalTrials.gov
NCT00397683ODANACATIBPHASE2ClinicalTrials.gov

NIH grants 2233

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant292,025NIH's project files
P30CA016672Cancer Center Support Grant122,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT112,025NIH's project files
R01AR062173The IL-23/IL-17 Axis in Inflammatory Arthritis92,025NIH's project files
P30CA006973Regional Oncology Research Center82,025NIH's project files
P50CA217694SPORE in Soft Tissue Sarcoma82,025NIH's project files
R01AR046713Cytokine regulation of RA synoviocyte phenotype82,025NIH's project files
P30AR069620Michigan Integrative Musculoskeletal Health Core Center (Overall Application)62,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award62,025NIH's project files
P20GM103432Wyoming IDeA Networks for Biomedical Research Excellence Phase 452,025NIH's project files

Papers 6707

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822817PubTator, text miningPubMed
42821566PubTator, text miningPubMed
42815372PubTator, text miningPubMed
42815330PubTator, text miningPubMed
42806417PubTator, text miningPubMed
42794684PubTator, text miningPubMed
42773115PubTator, text miningPubMed
42761021PubTator, text miningPubMed
42756821PubTator, text miningPubMed
42737778PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license