Gene · 151306
GPBAR1: G protein-coupled bile acid receptor 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GPBAR1: G protein-coupled bile acid receptor 1. Genes, record 151306. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/151306
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8TDU6 | G protein-coupled bile acid receptor 1 | 330 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents73
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 46946 | Q8TDU6 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 46947 | Q8TDU6 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 46948 | Q8TDU6 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 46949 | Q8TDU6 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1766 | Q8TDU6 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1766 | Q8TDU6 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 33385 | Q8TDU6 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 33386 | Q8TDU6 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 33387 | Q8TDU6 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 33388 | Q8TDU6 | Espacenet |
1 to 10 of 73
See all 73 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,151
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GPBAR1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 14 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 7 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 7 | 2025 |
| P30DK034989 | Yale Liver Center | 6 | 2025 |
| P30DK036836 | Diabetes Research Center | 6 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 6 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 5 | 2025 |
| P30DK078392 | Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease | 5 | 2025 |
| P30DK120515 | San Diego Digestive Diseases Research Center | 5 | 2025 |
| R01DK057993 | Pathophysiology of Biliary Disease | 5 | 2025 |
1 to 10 of 1,151Source NIH's project files
See all 1,151 nih grantsPapers2,833
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The gut-liver-brain axis in alcohol use disorder: The emerging role of bile acid dysregulation. | Behav Brain Res | 2027 | 42763054 | PubTator, text mining | PubMed |
| Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling. | J Ethnopharmacol | 2027 | 42503322 | PubTator, text mining | PubMed |
| Decoding dietary fat: molecular sensing, brain integration, and the biology of flavor. | Can J Physiol Pharmacol | 2026 | 42826400 | PubTator, text mining | PubMed |
| Bile acid signaling in health and disease. | Mol Biomed | 2026 | 42825856 | PubTator, text mining | PubMed |
| Gut microbiota-host co-metabolism in hypertriglyceridemia-associated acute pancreatitis: from causality to precision intervention. | Front Immunol | 2026 | 42819668 | PubTator, text mining | PubMed |
| Bile acids as a "new hormone" in aging-related liver disease. | Life Med | 2026 | 42813208 | PubTator, text mining | PubMed |
| The Bile Acid Signaling Axis: Deciphering the Roles of FXR and TGR5 in Hepatic Steatosis, Fibrosis, and Cancer. | Pharmacol Res Perspect | 2026 | 42811458 | PubTator, text mining | PubMed |
| Molecular mechanisms of lipid sensing in human cholecystokinin-secreting enteroendocrine cells. | Mol Metab | 2026 | 42805486 | PubTator, text mining | PubMed |
| Microbiota-Mediator-Host Signaling Networks in Metabolic Syndrome: From Mechanistic Insights to Therapeutic Targeting. | Microorganisms | 2026 | 42795448 | PubTator, text mining | PubMed |
| The Gut-Heart Axis in Cardiovascular Disease: Microbial Metabolites, Mediterranean and Traditional Turkish Dietary Patterns, and Personalized Medicine. | Int J Mol Sci | 2026 | 42794738 | PubTator, text mining | PubMed |
1 to 10 of 2,833
See all 2,833 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/151306
GET https://conductscience.org/api/genes/v1/151306/patents?page=2