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Gene · 151306

GPBAR1: G protein-coupled bile acid receptor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GPBAR1: G protein-coupled bile acid receptor 1. Genes, record 151306. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/151306

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Gene

Symbol
GPBAR1
HGNC
Name
G protein-coupled bile acid receptor 1
HGNC
NCBI Gene ID
151306
NCBI Gene
HGNC ID
HGNC:19680
HGNC
Ensembl
ENSG00000179921
NCBI Gene
Aliases
BG37, GPCR, GPCR19, GPR131, M-BAR, MGC40597, TGR5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8TDU6G protein-coupled bile acid receptor 13305Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1446946Q8TDU6Espacenet
JP 2026004568 A2026-01-1446947Q8TDU6Espacenet
JP 2026004568 A2026-01-1446948Q8TDU6Espacenet
JP 2026004568 A2026-01-1446949Q8TDU6Espacenet
JP 2025529142 A2025-09-041766Q8TDU6Espacenet
US 12371689 B22025-07-291766Q8TDU6Espacenet
US 11446398 B22022-09-2033385Q8TDU6Espacenet
US 11446398 B22022-09-2033386Q8TDU6Espacenet
US 11446398 B22022-09-2033387Q8TDU6Espacenet
US 11446398 B22022-09-2033388Q8TDU6Espacenet

1 to 10 of 73

See all 73 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,151

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGPBAR1 papersNewest fiscal year
P30DK084567Mayo Center for Cell Signaling in Gastroenterology142025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)72025
P30DK058404Molecular and Cellular Basis for Digestive Diseases72025
P30DK034989Yale Liver Center62025
P30DK036836Diabetes Research Center62025
P30DK056338Texas Medical Center Digestive Diseases Center62025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease52025
P30DK120515San Diego Digestive Diseases Research Center52025
R01DK057993Pathophysiology of Biliary Disease52025

1 to 10 of 1,151Source NIH's project files

See all 1,151 nih grants

Papers2,833

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The gut-liver-brain axis in alcohol use disorder: The emerging role of bile acid dysregulation.Behav Brain Res202742763054PubTator, text miningPubMed
Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling.J Ethnopharmacol202742503322PubTator, text miningPubMed
Decoding dietary fat: molecular sensing, brain integration, and the biology of flavor.Can J Physiol Pharmacol202642826400PubTator, text miningPubMed
Bile acid signaling in health and disease.Mol Biomed202642825856PubTator, text miningPubMed
Gut microbiota-host co-metabolism in hypertriglyceridemia-associated acute pancreatitis: from causality to precision intervention.Front Immunol202642819668PubTator, text miningPubMed
Bile acids as a "new hormone" in aging-related liver disease.Life Med202642813208PubTator, text miningPubMed
The Bile Acid Signaling Axis: Deciphering the Roles of FXR and TGR5 in Hepatic Steatosis, Fibrosis, and Cancer.Pharmacol Res Perspect202642811458PubTator, text miningPubMed
Molecular mechanisms of lipid sensing in human cholecystokinin-secreting enteroendocrine cells.Mol Metab202642805486PubTator, text miningPubMed
Microbiota-Mediator-Host Signaling Networks in Metabolic Syndrome: From Mechanistic Insights to Therapeutic Targeting.Microorganisms202642795448PubTator, text miningPubMed
The Gut-Heart Axis in Cardiovascular Disease: Microbial Metabolites, Mediterranean and Traditional Turkish Dietary Patterns, and Personalized Medicine.Int J Mol Sci202642794738PubTator, text miningPubMed

1 to 10 of 2,833

See all 2,833 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/151306

GET https://conductscience.org/api/genes/v1/151306/patents?page=2