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Gene · 151888

BTLA: B and T lymphocyte associated

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BTLA: B and T lymphocyte associated. Genes, record 151888. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/151888

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Gene

Symbol
BTLA
HGNC
Name
B and T lymphocyte associated
HGNC
NCBI Gene ID
151888
NCBI Gene
HGNC ID
HGNC:21087
HGNC
Ensembl
ENSG00000186265
NCBI Gene
Aliases
BTLA1, CD272
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q7Z6A9B- and T-lymphocyte attenuator2895Ensembl, GeneID, HGNC

Source UniProt

Patents211

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4831196 A22026-10-2812Q7Z6A9Espacenet
JP 2026086729 A2026-05-2623Q7Z6A9Espacenet
US 12624087 B22026-05-1212Q7Z6A9Espacenet
US 12612446 B22026-04-28453Q7Z6A9Espacenet
JP 2026021532 A2026-02-10225Q7Z6A9Espacenet
EP 4680651 A12026-01-2170Q7Z6A9Espacenet
JP 2025541734 A2025-12-2329Q7Z6A9Espacenet
JP 2025541604 A2025-12-2237Q7Z6A9Espacenet
JP 2025181929 A2025-12-11281Q7Z6A9Espacenet
EP 4650780 A22025-11-196055Q7Z6A9Espacenet

1 to 10 of 211

See all 211 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,652

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBTLA papersNewest fiscal year
P30CA016672Cancer Center Support Grant252025
P30CA008748Cancer Center Support Grant222025
P30CA006973Regional Oncology Research Center102025
P30CA076292Moffitt Cancer Center Support Grant92025
P30CA010815Consolidated Basic Cancer Research Program82025
P30CA021765Cancer Center Support Grant (CCSG)82025
P01AI039671Costimulatory Mechanisms of Autoimmunity72025
R35GM118097Mechanism of Immune Dysfunction and Morbid Outcomes in Response to Shock/Sepsis72025
U19AI082630Durable Alteration of the Human Immune system after Infection or Immunotherapy72025
UL1TR001863Yale Clinical and Translational Science Award72025

1 to 10 of 1,652Source NIH's project files

See all 1,652 nih grants

Papers3,415

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Small extracellular vesicles from the plasma of head and neck cancer patients induce dysfunctional T cell phenotypes.Br J Cancer202642800812PubTator, text miningPubMed
Mutant HVEM in lymphoma disrupts BTLA and CD160 regulation of anti-tumor signaling.Front Immunol202642798506PubTator, text miningPubMed
Molecular Architecture and Clinical Landscape of Immune Checkpoint Receptors and Ligands.Antibodies (Basel)202642776797PubTator, text miningPubMed
Beyond PD-L1/PD-1: expression of PVR/TIGIT and TNFRSF14/BTLA axes in response to Helicobacter pylori and in gastric cancer lesions.Immunohorizons202642772936PubTator, text miningPubMed
Role of BTLA in ovarian cancer and its clinical prognostic significance based on multi-omics analysis.J Ovarian Res202642754905PubTator, text miningPubMed
A multi-omics integrative analyses reveals CYBB-mediated apoptotic and immune dysregulation as a key target of berberine in diffuse large B-cell lymphoma.Front Pharmacol202642730162PubTator, text miningPubMed
STC1 is associated with tumor progression and suppressive niches in laryngeal squamous cell carcinoma.Transl Cancer Res202642724726PubTator, text miningPubMed
Single cell mapping of B and T cell dynamics in breast cancer lymph node metastasis.Front Bioinform202642656703PubTator, text miningPubMed
Elevated BTLA Expression Correlates with an Immunosuppressive Microenvironment and Defines Dysfunctional Circulating T Cells in Human Glioblastoma.Med Sci (Basel)202642646567PubTator, text miningPubMed
The BTLA/HVEM axis as a key regulator for stratified functional cure in chronic hepatitis B.Front Immunol202642638743PubTator, text miningPubMed

1 to 10 of 3,415

See all 3,415 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/151888

GET https://conductscience.org/api/genes/v1/151888/patents?page=2