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Gene · 152

ADRA2C: adrenoceptor alpha 2C

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADRA2C: adrenoceptor alpha 2C. Genes, record 152. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/152

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Gene

Symbol
ADRA2C
HGNC
Name
adrenoceptor alpha 2C
HGNC
NCBI Gene ID
152
NCBI Gene
HGNC ID
HGNC:283
HGNC
Ensembl
ENSG00000184160
NCBI Gene
Aliases
ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P18825Alpha-2C adrenergic receptor4621Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436847P18825Espacenet
JP 2025529142 A2025-09-04335P18825Espacenet
US 12371689 B22025-07-29335P18825Espacenet
JP 2025062604 A2025-04-143469P18825Espacenet
US 11446398 B22022-09-203469P18825Espacenet
US 11400116 B22022-08-02198P18825Espacenet
JP 2022524081 A2022-04-27106440P18825Espacenet
US 11078247 B22021-08-03305P18825Espacenet
US 10772934 B22020-09-151229P18825Espacenet
US 10302646 B22019-05-28153P18825Espacenet

1 to 10 of 24

See all 24 patents

Drugs67

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALSEROXYLONCHEMBL1201454Adrenergic receptor alpha antagonistANTAGONISTChEMBL
APRACLONIDINECHEMBL647Adrenergic receptor alpha-2 agonistAGONISTChEMBL
APRACLONIDINE HYDROCHLORIDECHEMBL1200379Adrenergic receptor alpha-2 agonistAGONISTChEMBL
AVIPTADILCHEMBL1981592Adrenergic receptor alpha antagonistANTAGONISTChEMBL
BRIMONIDINECHEMBL844Adrenergic receptor alpha-2 agonistAGONISTChEMBL
BRIMONIDINE TARTRATECHEMBL1200389Adrenergic receptor alpha-2 agonistAGONISTChEMBL
CELIPROLOLCHEMBL27810Adrenergic receptor alpha-2 antagonistANTAGONISTChEMBL
CLONIDINECHEMBL134Adrenergic receptor alpha-2 agonistAGONISTChEMBL
CLONIDINE HYDROCHLORIDECHEMBL1705Adrenergic receptor alpha-2 agonistAGONISTChEMBL
DEXMEDETOMIDINECHEMBL778Adrenergic receptor alpha-2 agonistAGONISTChEMBL

1 to 10 of 67

See all 67 drugs

Trials1,038

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603596DEXMEDETOMIDINEPHASE1ClinicalTrials.gov
NCT07585201DEXMEDETOMIDINEClinicalTrials.gov
NCT07573969DEXMEDETOMIDINEPHASE3ClinicalTrials.gov
NCT07572656LABETALOLClinicalTrials.gov
NCT07569536DEXMEDETOMIDINEPHASE3ClinicalTrials.gov
NCT07564531DEXMEDETOMIDINEClinicalTrials.gov
NCT07557680DEXMEDETOMIDINEPHASE3ClinicalTrials.gov
NCT07542990DEXMEDETOMIDINEPHASE3ClinicalTrials.gov
NCT07537894DEXMEDETOMIDINEPHASE2/PHASE3ClinicalTrials.gov
NCT07532733DEXMEDETOMIDINEClinicalTrials.gov

1 to 10 of 1,038

See all 1,038 trials

NIH grants730

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADRA2C papersNewest fiscal year
R35GM136397GPCR anterograde trafficking42025
ZIAAA000301Integrative genetics of behavior with high throughput technologies42025
P30CA021765Cancer Center Support Grant (CCSG)22025
P30DK020579Diabetes Research Center22025
ZIADA000493Functional and Pharmacological Significance of Receptor Heteromers in the CNS22025
ZIADA000606Structural basis for the functions of dopamine receptors, neurotransmitter transporters, and sigma 1 receptor22025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens12025
P01CA108671Myeloproliferative Neoplasms-Research Consortium12025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes12025
P30AR073752Washington University Rheumatic Diseases Research Resource-based Center12025

1 to 10 of 730Source NIH's project files

See all 730 nih grants

Papers944

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
JP-1302 inhibits RNA polymerase I transcription and induces nucleolar stress in cancer cell lines.Cell Death Discov202642816485PubTator, text miningPubMed
Endometriosis pain: genes linked to inflammation distinguish symptomatic from asymptomatic disease.Mol Hum Reprod202642720599PubTator, text miningPubMed
Novel Substituted Heterocyclic Carboxamindes as α2C-ARs Antagonists.ACS Med Chem Lett202642445021PubTator, text miningPubMed
An Exploratory Study of High-Concentration Trace Amine Effects and Adrenoceptor Expression Patterns in SH-SY5Y Cells and Neuroblastoma.Int J Mol Sci202642278562PubTator, text miningPubMed
Leveraging Signal Detection and Mendelian Randomization in Spontaneous Reporting for Post-Marketing Surveillance of Drug- Induced Amnesia.Curr Med Chem202641941166PubTator, text miningPubMed
Neuroimmunological Mechanisms of Xiao-Yao-San Against Chronic Stress-Induced Colorectal Cancer: A Bioinformatics and Single-Cell Sequencing Study.Cancer Manag Res202641798904PubTator, text miningPubMed
ROCK signaling at the crossroads of redox stress, mitochondrial dynamics, and metabolic disease.Redox Biol202641791289PubTator, text miningPubMed
Integrative network toxicology and experimental evidence reveal mechanisms underlying diethyl phthalate-induced initiation and progression of endometrial cancer.Sci Rep202641667778PubTator, text miningPubMed
Ribosome biogenesis is increased in hepatocellular carcinoma and represents a potential therapeutic target.NAR Cancer202641551405PubTator, text miningPubMed
Ribosome occupancy and miRNA-mediated silencing of upregulated genes in attention deficit hyperactivity disorder.Comput Biol Chem202641391262PubTator, text miningPubMed

1 to 10 of 944

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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