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CTSS: cathepsin S

1 protein, 102 patents, 1 drug, 1 trial, 4,858 NIH grants and 8,800 papers.

Gene 6

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCTSSHGNC
Namecathepsin SHGNC
NCBI Gene ID1520NCBI Gene
HGNC IDHGNC:2545HGNC
EnsemblENSG00000163131NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P25774Cathepsin S33162Ensembl, GeneID, HGNCUniProt

Patents 102

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0344P25774Espacenet
JP 2026004568 A2026-01-1440338P25774Espacenet
EP 4662329 A12025-12-17325P25774Espacenet
EP 4662491 A22025-12-172609P25774Espacenet
EP 4650780 A22025-11-198541P25774Espacenet
EP 4640849 A22025-10-291289P25774Espacenet
EP 4641201 A22025-10-298705P25774Espacenet
JP 2025534299 A2025-10-1543P25774Espacenet
JP 2025147176 A2025-10-063763P25774Espacenet
JP 2025529142 A2025-09-046063P25774Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PETESICATIBCHEMBL4297638Cathepsin S inhibitorINHIBITORChEMBL

Trials 1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02679014PETESICATIBPHASE1ClinicalTrials.gov

NIH grants 4858

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant202,025NIH's project files
R01EY011386Microtubule-based Transport in Lacrimal Gland Function182,025NIH's project files
P50AA011999Southern California Research Center for ALPD and Cirrhosis132,025NIH's project files
P30CA006973Regional Oncology Research Center92,025NIH's project files
P30CA014051Cancer Center Support (Core) Grant92,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant82,025NIH's project files
R01EY026635Protein-polymer nanomedicine for Sjogren's Syndrome82,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant72,025NIH's project files
P30ES005605Environmental Health Sciences Research Center72,025NIH's project files
P30EY005722Center Core Grant for Vision Research72,025NIH's project files

Papers 8800

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42804124PubTator, text miningPubMed
42760737PubTator, text miningPubMed
42757770PubTator, text miningPubMed
42731187PubTator, text miningPubMed
42728627PubTator, text miningPubMed
42726435PubTator, text miningPubMed
42709258PubTator, text miningPubMed
42698964PubTator, text miningPubMed
42679909PubTator, text miningPubMed
42653132PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license