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Gene · 1528

CYB5A: cytochrome b5 type A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CYB5A: cytochrome b5 type A. Genes, record 1528. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1528

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Gene

Symbol
CYB5A
HGNC
Name
cytochrome b5 type A
HGNC
NCBI Gene ID
1528
NCBI Gene
HGNC ID
HGNC:2570
HGNC
Ensembl
ENSG00000166347
NCBI Gene
Aliases
CYB5, MCB5, METAG
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P00167Cytochrome b51341Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4752548 A12026-06-031P00167Espacenet
EP 4685238 A22026-01-2848P00167Espacenet
JP 2026004568 A2026-01-1442783P00167Espacenet
EP 4650780 A22025-11-196662P00167Espacenet
JP 2025529142 A2025-09-041171P00167Espacenet
US 12371689 B22025-07-291171P00167Espacenet
JP 2025517970 A2025-06-126662P00167Espacenet
JP 2025032204 A2025-03-1126974P00167Espacenet
EP 4461818 A22024-11-1326974P00167Espacenet
JP 2023554542 A2023-12-2753P00167Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,255

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCYB5A papersNewest fiscal year
R01GM086596Activation of androgen biosynthesis and drug metabolism by cytochrome b5272025
R01DK043140Mechanisms Leading to Adrenal Zonation122025
R35GM118145Nanoscale Approaches to Understanding Membrane Protein Function112025
P30DK089503Michigan Nutrition Obesity Research Center62025
T32ES007028Training Program in Environmental Toxicology62025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment52025
R01HL098032Omics, mice and men: Development of precision transfusion medicine52025
T32ES007015Molecular & Environmental Toxicology Predoctoral Training Program52025
T32OD010423Comparative Biomedical Sciences Training Program52025
P30DK026743UCSF Liver Center42025

1 to 10 of 1,255Source NIH's project files

See all 1,255 nih grants

Papers2,882

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Familial 46,XY disorder of sex development due to a novel CYB5A variant: a rare cause of isolated 17,20-lyase deficiency.JCEM Case Rep202642824631PubTator, text miningPubMed
Submicellar aggregates of deoxycholate and glycodeoxycholate suppress in vitro CYP3A oxidation via membrane perturbation.Drug Metab Dispos202642822376PubTator, text miningPubMed
Divergence of the CYB5R3-mARC1 Redox Axis Across the Human MASLD-to-Hepatocellular-Carcinoma Continuum: An Exploratory Analysis of Liver-Biopsy and Tumor Cohorts.Int J Mol Sci202642737704PubTator, text miningPubMed
Enhancing the activity of the bifunctional membrane Δ12-hydroxylase/desaturase CpFAH12: Key insights from redox partner interactions and electron transfer pathways.Int J Biol Macromol202642575354PubTator, text miningPubMed
High-level expression of full-length human CYP2E1 in Escherichia coli: Comparison of full-length human CYP2E1 to truncated counterpart shows enhanced association with redox partners.Drug Metab Dispos202642398471PubTator, text miningPubMed
Novel Perspective for Prognostic Stratification and Personalized Therapy in Breast Cancer Patients: Development of Cancer Stem Cells and Metabolism-Associated Prognostic Model.Int J Womens Health202642358344PubTator, text miningPubMed
Free Radical Formation in the Reactions of Redox-Active Drugs and Xenobiotics with Mitochondrial Flavoenzymes.Biomolecules202642352277PubTator, text miningPubMed
Photothermal Conversion and Temperature Elevation by a Minimal Heme Protein.J Phys Chem B202642343696PubTator, text miningPubMed
Integrated Bulk and Single-Cell Transcriptomic Analysis Reveals Xenobiotic Metabolism Genes Drive Progression From Liver Cirrhosis to Hepatocellular Carcinoma.Hum Mutat202642136961PubTator, text miningPubMed
Development and Validation of a Quantitative LC-MS/MS Method for Measuring CYP4V2 Enzyme Activity via 12-Hydroxylauric Acid in rAAV-hCYP4V2 Gene Therapy Products.Molecules202642123783PubTator, text miningPubMed

1 to 10 of 2,882

See all 2,882 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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