Gene · 152831
KLB: klotho beta
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KLB: klotho beta. Genes, record 152831. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/152831
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q86Z14 | Beta-klotho | 1,044 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents112
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12534503 B2 | 2026-01-27 | 1 | Q86Z14 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50957 | Q86Z14 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1238 | Q86Z14 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2310 | Q86Z14 | Espacenet |
| US 12378312 B2 | 2025-08-05 | 297 | Q86Z14 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2310 | Q86Z14 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1238 | Q86Z14 | Espacenet |
| EP 4458852 A1 | 2024-11-06 | 52 | Q86Z14 | Espacenet |
| US 12116413 B2 | 2024-10-15 | 7 | Q86Z14 | Espacenet |
| US 12116413 B2 | 2024-10-15 | 359 | Q86Z14 | Espacenet |
1 to 10 of 112
See all 112 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials18
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06654726 | ALDAFERMIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT05130047 | ALDAFERMIN | PHASE2 | 2023-10-12 | ClinicalTrials.gov |
| NCT04210245 | ALDAFERMIN | PHASE2 | 2025-03-26 | ClinicalTrials.gov |
| NCT04179630 | ALDAFERMIN | PHASE1 | ClinicalTrials.gov | |
| NCT04171765 | FAZPILODEMAB | PHASE2 | 2024-04-16 | ClinicalTrials.gov |
| NCT03912532 | ALDAFERMIN | PHASE2 | 2025-07-03 | ClinicalTrials.gov |
| NCT03486912 | PEGBELFERMIN | PHASE2 | 2022-10-13 | ClinicalTrials.gov |
| NCT03486899 | PEGBELFERMIN | PHASE2 | 2022-09-09 | ClinicalTrials.gov |
| NCT03400163 | PEGBELFERMIN | PHASE2 | 2020-02-19 | ClinicalTrials.gov |
| NCT03060538 | FAZPILODEMAB | PHASE1 | ClinicalTrials.gov |
1 to 10 of 18
See all 18 trialsNIH grants1,117
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KLB papers | Newest fiscal year |
|---|---|---|---|
| R01DK106104 | Regulation of Metabolism by FGF21 | 13 | 2025 |
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 12 | 2025 |
| T32DK112751 | Diabetes Research Training Program | 7 | 2025 |
| P01AG051459 | Competing Renewal P01 | 6 | 2025 |
| P50AA022537 | Cross-species investigation of gene networks for ethanol-related behaviors | 6 | 2025 |
| DP1DA054394 | Building Bridges to Allow Cross-species Translational genetics for the Study of Addiction | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30DK054759 | Precision Medicine Center for Cystic Fibrosis | 4 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 4 | 2025 |
| P30DK072476 | Pennington/Louisiana NORC | 4 | 2025 |
1 to 10 of 1,117Source NIH's project files
See all 1,117 nih grantsPapers1,542
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Moderated mediation of cerebrospinal fluid fibroblast growth factor 21 and KLB rs17618244 genotype in the association between educational attainment and cognitive function. | Behav Brain Res | 2027 | 42700933 | PubTator, text mining | PubMed |
| βKlotho filters ligand-independent FGFR1/4-PLCγ signaling to prevent aberrant constitutive Ca2+ entry. | Korean J Physiol Pharmacol | 2026 | 42825310 | PubTator, text mining | PubMed |
| Pharmaceutical Strategies for Translating Klotho-Based Therapeutics: From Biologic Developability to Advanced Delivery Systems. | Pharmaceutics | 2026 | 42797299 | PubTator, text mining | PubMed |
| FGF/FGFR signaling in hepatocellular carcinoma: From molecular mechanisms to biomarker-guided therapy. | Cancer Treat Res Commun | 2026 | 42753578 | PubTator, text mining | PubMed |
| Interrelationship between Serum FGF21, GDF15, and Microalbuminuria as Predictive Biomarkers for Early Detection of Diabetic Retinopathy in Type 2 Diabetes Mellitus. | EJIFCC | 2026 | 42699480 | PubTator, text mining | PubMed |
| Adipose FGF21 signalling mediates the anti-senescence effects of protein restriction. | J Physiol | 2026 | 42664385 | PubTator, text mining | PubMed |
| Fibroblast growth factor 21 and its relationship with central precocious puberty in girls. | Endocr Connect | 2026 | 42593781 | PubTator, text mining | PubMed |
| FGF21 as a Potential Mediator of Ultra-Processed Food-Associated Metabolic Dysfunction-Associated Steatotic Liver Disease and the Protective Effect of Bilberry Extract. | Nutrients | 2026 | 42588053 | PubTator, text mining | PubMed |
| FGF21 in idiopathic pulmonary fibrosis: mechanistic insights, translational potential, and unresolved questions. | J Thorac Dis | 2026 | 42583386 | PubTator, text mining | PubMed |
| Biomarker-guided pharmacotherapy in cardiovascular-kidney-metabolic syndrome: A three-dimensional framework for precision drug selection and monitoring. | Pharmacol Ther | 2026 | 42492739 | PubTator, text mining | PubMed |
1 to 10 of 1,542
See all 1,542 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/152831
GET https://conductscience.org/api/genes/v1/152831/patents?page=2