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Gene · 152831

KLB: klotho beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KLB: klotho beta. Genes, record 152831. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/152831

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Gene

Symbol
KLB
HGNC
Name
klotho beta
HGNC
NCBI Gene ID
152831
NCBI Gene
HGNC ID
HGNC:15527
HGNC
Ensembl
ENSG00000134962
NCBI Gene
Aliases
BKL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q86Z14Beta-klotho1,0445Ensembl, GeneID, HGNC

Source UniProt

Patents112

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12534503 B22026-01-271Q86Z14Espacenet
JP 2026004568 A2026-01-1450957Q86Z14Espacenet
EP 4641201 A22025-10-291238Q86Z14Espacenet
JP 2025529142 A2025-09-042310Q86Z14Espacenet
US 12378312 B22025-08-05297Q86Z14Espacenet
US 12371689 B22025-07-292310Q86Z14Espacenet
JP 2025517969 A2025-06-121238Q86Z14Espacenet
EP 4458852 A12024-11-0652Q86Z14Espacenet
US 12116413 B22024-10-157Q86Z14Espacenet
US 12116413 B22024-10-15359Q86Z14Espacenet

1 to 10 of 112

See all 112 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALDAFERMINCHEMBL4298055FGF1/KLB activatorACTIVATORChEMBL
ALDAFERMINCHEMBL4298055FGFR4-KLB activatorACTIVATORChEMBL
FAZPILODEMABCHEMBL4297909FGF1/KLB agonistAGONISTChEMBL
PEGBELFERMINCHEMBL4297578FGF1/KLB agonistAGONISTChEMBL

Trials18

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06654726ALDAFERMINPHASE2/PHASE3ClinicalTrials.gov
NCT05130047ALDAFERMINPHASE22023-10-12ClinicalTrials.gov
NCT04210245ALDAFERMINPHASE22025-03-26ClinicalTrials.gov
NCT04179630ALDAFERMINPHASE1ClinicalTrials.gov
NCT04171765FAZPILODEMABPHASE22024-04-16ClinicalTrials.gov
NCT03912532ALDAFERMINPHASE22025-07-03ClinicalTrials.gov
NCT03486912PEGBELFERMINPHASE22022-10-13ClinicalTrials.gov
NCT03486899PEGBELFERMINPHASE22022-09-09ClinicalTrials.gov
NCT03400163PEGBELFERMINPHASE22020-02-19ClinicalTrials.gov
NCT03060538FAZPILODEMABPHASE1ClinicalTrials.gov

1 to 10 of 18

See all 18 trials

NIH grants1,117

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKLB papersNewest fiscal year
R01DK106104Regulation of Metabolism by FGF21132025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).122025
T32DK112751Diabetes Research Training Program72025
P01AG051459Competing Renewal P0162025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors62025
DP1DA054394Building Bridges to Allow Cross-species Translational genetics for the Study of Addiction42025
P30CA008748Cancer Center Support Grant42025
P30DK054759Precision Medicine Center for Cystic Fibrosis42025
P30DK056338Texas Medical Center Digestive Diseases Center42025
P30DK072476Pennington/Louisiana NORC42025

1 to 10 of 1,117Source NIH's project files

See all 1,117 nih grants

Papers1,542

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Moderated mediation of cerebrospinal fluid fibroblast growth factor 21 and KLB rs17618244 genotype in the association between educational attainment and cognitive function.Behav Brain Res202742700933PubTator, text miningPubMed
βKlotho filters ligand-independent FGFR1/4-PLCγ signaling to prevent aberrant constitutive Ca2+ entry.Korean J Physiol Pharmacol202642825310PubTator, text miningPubMed
Pharmaceutical Strategies for Translating Klotho-Based Therapeutics: From Biologic Developability to Advanced Delivery Systems.Pharmaceutics202642797299PubTator, text miningPubMed
FGF/FGFR signaling in hepatocellular carcinoma: From molecular mechanisms to biomarker-guided therapy.Cancer Treat Res Commun202642753578PubTator, text miningPubMed
Interrelationship between Serum FGF21, GDF15, and Microalbuminuria as Predictive Biomarkers for Early Detection of Diabetic Retinopathy in Type 2 Diabetes Mellitus.EJIFCC202642699480PubTator, text miningPubMed
Adipose FGF21 signalling mediates the anti-senescence effects of protein restriction.J Physiol202642664385PubTator, text miningPubMed
Fibroblast growth factor 21 and its relationship with central precocious puberty in girls.Endocr Connect202642593781PubTator, text miningPubMed
FGF21 as a Potential Mediator of Ultra-Processed Food-Associated Metabolic Dysfunction-Associated Steatotic Liver Disease and the Protective Effect of Bilberry Extract.Nutrients202642588053PubTator, text miningPubMed
FGF21 in idiopathic pulmonary fibrosis: mechanistic insights, translational potential, and unresolved questions.J Thorac Dis202642583386PubTator, text miningPubMed
Biomarker-guided pharmacotherapy in cardiovascular-kidney-metabolic syndrome: A three-dimensional framework for precision drug selection and monitoring.Pharmacol Ther202642492739PubTator, text miningPubMed

1 to 10 of 1,542

See all 1,542 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/152831

GET https://conductscience.org/api/genes/v1/152831/patents?page=2