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ADRB1: adrenoceptor beta 1

1 protein, 93 patents, 74 drugs, 1,230 trials, 3,429 NIH grants and 6,187 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolADRB1HGNC
Nameadrenoceptor beta 1HGNC
NCBI Gene ID153NCBI Gene
HGNC IDHGNC:285HGNC
EnsemblENSG00000043591NCBI Gene
AliasesADRB1R, B1AR, BETA1AR, FNSS2, RHRNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08588Beta-1 adrenergic receptor4777Ensembl, GeneID, HGNCUniProt

Patents 93

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436851P08588Espacenet
EP 4640849 A22025-10-291296P08588Espacenet
EP 4641201 A22025-10-298760P08588Espacenet
JP 2025519096 A2025-06-241296P08588Espacenet
JP 2025517969 A2025-06-128760P08588Espacenet
JP 2025062604 A2025-04-143471P08588Espacenet
EP 4491229 A22025-01-154P08588Espacenet
WO 2024230934 A12024-11-14129P08588Espacenet
US 11761043 B22023-09-194P08588Espacenet
US 11673938 B22023-06-132P08588Espacenet

Drugs 74

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACEBUTOLOLCHEMBL642Beta-1 adrenergic receptor antagonistANTAGONISTChEMBL
ACEBUTOLOL HYDROCHLORIDECHEMBL1200813Beta-1 adrenergic receptor antagonistANTAGONISTChEMBL
ATENOLOLCHEMBL24Beta-1 adrenergic receptor antagonistANTAGONISTChEMBL
BETAXOLOLCHEMBL423Beta-1 adrenergic receptor antagonistANTAGONISTChEMBL
BETAXOLOL HYDROCHLORIDECHEMBL1691Beta-1 adrenergic receptor antagonistANTAGONISTChEMBL
BISOPROLOLCHEMBL645Beta-1 adrenergic receptor antagonistANTAGONISTChEMBL
BISOPROLOL FUMARATECHEMBL1472989Beta-1 adrenergic receptor antagonistANTAGONISTChEMBL
BUCINDOLOLCHEMBL321582Beta-1 adrenergic receptor antagonistANTAGONISTChEMBL
BUCINDOLOL HYDROCHLORIDECHEMBL2107546Beta-1 adrenergic receptor antagonistANTAGONISTChEMBL
CARTEOLOLCHEMBL839Adrenergic receptor beta antagonistANTAGONISTChEMBL

Trials 1230

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603596ESMOLOLPHASE1ClinicalTrials.gov
NCT07577518CARVEDILOLClinicalTrials.gov
NCT07572656LABETALOLClinicalTrials.gov
NCT07560332PROPRANOLOLClinicalTrials.gov
NCT07560332TIMOLOLClinicalTrials.gov
NCT07549906PROPRANOLOLPHASE2ClinicalTrials.gov
NCT07511894METOPROLOL SUCCINATEPHASE2ClinicalTrials.gov
NCT07491718BISOPROLOLClinicalTrials.gov
NCT07442643EPINEPHRINEClinicalTrials.gov
NCT07442071EPINEPHRINEPHASE3ClinicalTrials.gov

NIH grants 3429

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors202,025NIH's project files
R01HL056687Mechanisms of Maladaptation in Heart Failure152,025NIH's project files
R01DA012864Mechanisms and Cellular Function of Opioid Receptor Endocytosis132,025NIH's project files
P30CA016672Cancer Center Support Grant82,025NIH's project files
R01EY011500Structure-function studies of visual arrestin72,025NIH's project files
R01MH054137Structure and Function of Dopamine Receptors72,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)62,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility52,025NIH's project files
R01AG055357Dysregulation of Cav1.2 by beta amyloid peptide52,025NIH's project files
R01DK097441Molecular mechanisms of UCP1-independent pathways in metabolic health52,025NIH's project files

Papers 6187

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42769728PubTator, text miningPubMed
42750652PubTator, text miningPubMed
42749427PubTator, text miningPubMed
42743088PubTator, text miningPubMed
42724479PubTator, text miningPubMed
42722881PubTator, text miningPubMed
42702173PubTator, text miningPubMed
42684683PubTator, text miningPubMed
42650112PubTator, text miningPubMed
42640698PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license