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Gene · 1535

CYBA: cytochrome b-245 alpha chain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CYBA: cytochrome b-245 alpha chain. Genes, record 1535. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1535

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Gene

Symbol
CYBA
HGNC
Name
cytochrome b-245 alpha chain
HGNC
NCBI Gene ID
1535
NCBI Gene
HGNC ID
HGNC:2577
HGNC
Ensembl
ENSG00000051523
NCBI Gene
Aliases
CGD4, p22-PHOX, p22phox
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P13498Cytochrome b-245 light chain1957Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442762P13498Espacenet
EP 4650780 A22025-11-191925P13498Espacenet
JP 2025529142 A2025-09-041175P13498Espacenet
US 12371689 B22025-07-291175P13498Espacenet
JP 2025517970 A2025-06-121925P13498Espacenet
US 11446398 B22022-09-2021686P13498Espacenet
US 11408034 B22022-08-09379P13498Espacenet
US 11400116 B22022-08-0227P13498Espacenet
JP 2022524081 A2022-04-27124657P13498Espacenet
JP 2022511502 A2022-01-3198P13498Espacenet

1 to 10 of 36

See all 36 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,170

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCYBA papersNewest fiscal year
ZIAAI000646Transgenic Animal Models Of Human Immune Defects252025
ZIAAI000644Gene Therapy and Hematopoietic Stem Cell Research to Treat Inherited Primary Immune Deficiencies172025
ZIAAI000645Development and Clinical Application of Gene and Cell therapies for Patients with Immune Deficiencies172025
ZIABC010677NADPH Oxidases as Novel Targets for Cancer Therapy112025
P30CA016672Cancer Center Support Grant62025
P30CA016042Cancer Center Support Grant52025
P30CA054174Mays Cancer Center at UT Health SA52025
R01EY015130Mechanisms of Angiogenesis in ROP52025
R01EY017011Endothelial Transmigration in Neovascular Age-related Macular Degeneration52025
ZIAAI000989Development and conduct of allogeneic stem cell transplant and autologous stem cell gene therapy for inherited immune deficiencies52025

1 to 10 of 2,170Source NIH's project files

See all 2,170 nih grants

Papers3,801

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SPTLC2-driven sphingolipid reprogramming of neutrophils impairs anti-tumour immunity and drives liver cancer progression.Oncogene202642806133PubTator, text miningPubMed
Retraction: Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22phox-p38 MAPK signaling pathway.PLoS One202642784538PubTator, text miningPubMed
Human inborn errors of the phagocyte respiratory burst: Chronic granulomatous disease and beyond.J Hum Immun202642758005PubTator, text miningPubMed
Integrated Transcriptomic and Machine-Learning Analyses Identify Shared Na+ Overload-Related Gene Signatures in Inflammatory Bowel Disease and Ankylosing Spondylitis.Genes (Basel)202642650131PubTator, text miningPubMed
Targeting CYBA inhibits hepatic metastasis of pancreatic cancer through AKT/MLC2 pathway.Acta Pharmacol Sin202642624909PubTator, text miningPubMed
Pharmacogenomic variation and chemotherapy-related toxicity profiles in pediatric patients with cancer in Tanzania: a cross-sectional study.Front Pharmacol202642548792PubTator, text miningPubMed
Chronic granulomatous disease secondary to a rare compound heterozygote mutation in an adolescent cured by hematopoietic stem cell transplantation: a case report.Front Pediatr202642523956PubTator, text miningPubMed
Correction: Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22phox-p38 MAPK signaling pathway.PLoS One202642519998PubTator, text miningPubMed
A Multilevel Redox-Based Prognostic Model for Asthma Severity: From Genotype to Serum Biomarkers.Biomedicines202642511983PubTator, text miningPubMed
FOXC1: A Key Transcription Factor of VSMC-Derived Foam Cell Formation in Atherosclerotic Plaque Instability.Kaohsiung J Med Sci202642477884PubTator, text miningPubMed

1 to 10 of 3,801

See all 3,801 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1535

GET https://conductscience.org/api/genes/v1/1535/patents?page=2