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CYBB: cytochrome b-245 beta chain

1 protein, 53 patents, 0 drugs, 0 trials, 5,595 NIH grants and 12,313 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCYBBHGNC
Namecytochrome b-245 beta chainHGNC
NCBI Gene ID1536NCBI Gene
HGNC IDHGNC:2578HGNC
EnsemblENSG00000165168NCBI Gene
AliasesAMCBX2, CGD, CGDX, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOXNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04839NADPH oxidase 25706Ensembl, GeneID, HGNCUniProt

Patents 53

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442763P04839Espacenet
EP 4641201 A22025-10-2910342P04839Espacenet
EP 4641202 A22025-10-29567P04839Espacenet
JP 2025529142 A2025-09-041176P04839Espacenet
US 12371689 B22025-07-291176P04839Espacenet
JP 2025517969 A2025-06-1210342P04839Espacenet
KR 1020250017231 A2025-02-04567P04839Espacenet
KR 1020230088522 A2023-06-1927P04839Espacenet
US 11603568 B22023-03-1413P04839Espacenet
JP 2023509848 A2023-03-1037P04839Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5595

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAAI000644Gene Therapy and Hematopoietic Stem Cell Research to Treat Inherited Primary Immune Deficiencies452,025NIH's project files
ZIAAI000646Transgenic Animal Models Of Human Immune Defects442,025NIH's project files
ZIAAI000645Development and Clinical Application of Gene and Cell therapies for Patients with Immune Deficiencies432,025NIH's project files
P30CA016672Cancer Center Support Grant182,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)172,025NIH's project files
R01HL117913The NOTCH Signaling Pathway in Large Vessel Vasculitis172,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success162,025NIH's project files
P30DK054759Precision Medicine Center for Cystic Fibrosis152,025NIH's project files
ZIABC010677NADPH Oxidases as Novel Targets for Cancer Therapy152,025NIH's project files
ZIAAI000647Genes And Gene Products As Immunoadjuvants142,025NIH's project files

Papers 12313

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827395PubTator, text miningPubMed
42816061PubTator, text miningPubMed
42806133PubTator, text miningPubMed
42793133PubTator, text miningPubMed
42792195PubTator, text miningPubMed
42792177PubTator, text miningPubMed
42792163PubTator, text miningPubMed
42782772PubTator, text miningPubMed
42761201PubTator, text miningPubMed
42759114PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license