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Gene · 1540

CYLD: CYLD lysine 63 deubiquitinase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CYLD: CYLD lysine 63 deubiquitinase. Genes, record 1540. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1540

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Gene

Symbol
CYLD
HGNC
Name
CYLD lysine 63 deubiquitinase
HGNC
NCBI Gene ID
1540
NCBI Gene
HGNC ID
HGNC:2584
HGNC
Ensembl
ENSG00000083799
NCBI Gene
Aliases
BRSS, CDMT, CYLD1, CYLDI, EAC, FTDALS8, KIAA0849, MFT, MFT1, SBS, TEM, USPL2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NQC7Ubiquitin carboxyl-terminal hydrolase CYLD9566Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-294143Q9NQC7Espacenet
JP 2025524002 A2025-07-2514Q9NQC7Espacenet
JP 2025517969 A2025-06-124143Q9NQC7Espacenet
KR 1020250039465 A2025-03-2014Q9NQC7Espacenet
JP 2024123008 A2024-09-105828Q9NQC7Espacenet
JP 2024023699 A2024-02-2114Q9NQC7Espacenet
JP 2024505890 A2024-02-0814Q9NQC7Espacenet
US 11884978 B22024-01-30484Q9NQC7Espacenet
JP 2024501084 A2024-01-10244Q9NQC7Espacenet
JP 2023551068 A2023-12-0668Q9NQC7Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,873

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCYLD papersNewest fiscal year
P30CA008748Cancer Center Support Grant192025
P30CA016672Cancer Center Support Grant142025
ZIAHG200372Genetics, Pathophysiology, and Treatment of Autoinflammatory and Autoimmune Diseases82025
P01CA155258Integrative Oncogenomics of Multiple Myeloma62025
P30CA068485Cancer Center Support Grant62025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant52025
P30CA033572Cancer Center Support Grant52025
P30CA062203Cancer Center Support Grant52025
I01BX001584Molecular Manipulation to Enhance Anti-Myeloma Response42025
P20GM103476Mississippi INBRE42025

1 to 10 of 1,873Source NIH's project files

See all 1,873 nih grants

Papers3,467

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CYLD Mutations, PD-L1 and HPV; A Pan-Cancer Landscape Analysis.Res Sq202642818505PubTator, text miningPubMed
Anal canal neoplasms in the modern era: integrating HPV biology, LAST terminology, and evolving molecular classification.Virchows Arch202642771171PubTator, text miningPubMed
Aryl hydrocarbon receptor-dependent lipid droplet accumulation supports redox homeostasis in hypoxia-induced PCa cells.Am J Cancer Res202642724686PubTator, text miningPubMed
Phase 1 trial and biomarker analysis of Buparlisib with weekly Cisplatin and Radiotherapy in high risk locally advanced squamous cell cancer of the Head and Neck.Clin Cancer Res202642714839PubTator, text miningPubMed
Interactions Between E3 Ubiquitin Ligases and Deubiquitinases in AKT Regulation: Implications in Skeletal Muscle Homeostasis.Cell Biochem Funct202642671015PubTator, text miningPubMed
The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma (NPC) Differs by Somatostatin Receptor 2 (SSTR2) Expression.Cancer Med202642670259PubTator, text miningPubMed
Distinct mutational landscapes for germline and somatic cancer variants in forty tumor suppressor genes.Am J Hum Genet202642641600PubTator, text miningPubMed
The UVA-induced single-base mutational signature of CX-5461 in human cells.Nucleic Acids Res202642639791PubTator, text miningPubMed
Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation.Adv Sci (Weinh)202642627676PubTator, text miningPubMed
Deubiquitinating enzymes in kidney diseases: Molecular mechanisms, pathological roles and therapeutic opportunities (Review).Mol Med Rep202642627060PubTator, text miningPubMed

1 to 10 of 3,467

See all 3,467 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1540

GET https://conductscience.org/api/genes/v1/1540/patents?page=2