Gene · 1540
CYLD: CYLD lysine 63 deubiquitinase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CYLD: CYLD lysine 63 deubiquitinase. Genes, record 1540. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1540
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NQC7 | Ubiquitin carboxyl-terminal hydrolase CYLD | 956 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents35
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 4143 | Q9NQC7 | Espacenet |
| JP 2025524002 A | 2025-07-25 | 14 | Q9NQC7 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4143 | Q9NQC7 | Espacenet |
| KR 1020250039465 A | 2025-03-20 | 14 | Q9NQC7 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 5828 | Q9NQC7 | Espacenet |
| JP 2024023699 A | 2024-02-21 | 14 | Q9NQC7 | Espacenet |
| JP 2024505890 A | 2024-02-08 | 14 | Q9NQC7 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 484 | Q9NQC7 | Espacenet |
| JP 2024501084 A | 2024-01-10 | 244 | Q9NQC7 | Espacenet |
| JP 2023551068 A | 2023-12-06 | 68 | Q9NQC7 | Espacenet |
1 to 10 of 35
See all 35 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,873
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CYLD papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 19 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 14 | 2025 |
| ZIAHG200372 | Genetics, Pathophysiology, and Treatment of Autoinflammatory and Autoimmune Diseases | 8 | 2025 |
| P01CA155258 | Integrative Oncogenomics of Multiple Myeloma | 6 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 5 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 5 | 2025 |
| I01BX001584 | Molecular Manipulation to Enhance Anti-Myeloma Response | 4 | 2025 |
| P20GM103476 | Mississippi INBRE | 4 | 2025 |
1 to 10 of 1,873Source NIH's project files
See all 1,873 nih grantsPapers3,467
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| CYLD Mutations, PD-L1 and HPV; A Pan-Cancer Landscape Analysis. | Res Sq | 2026 | 42818505 | PubTator, text mining | PubMed |
| Anal canal neoplasms in the modern era: integrating HPV biology, LAST terminology, and evolving molecular classification. | Virchows Arch | 2026 | 42771171 | PubTator, text mining | PubMed |
| Aryl hydrocarbon receptor-dependent lipid droplet accumulation supports redox homeostasis in hypoxia-induced PCa cells. | Am J Cancer Res | 2026 | 42724686 | PubTator, text mining | PubMed |
| Phase 1 trial and biomarker analysis of Buparlisib with weekly Cisplatin and Radiotherapy in high risk locally advanced squamous cell cancer of the Head and Neck. | Clin Cancer Res | 2026 | 42714839 | PubTator, text mining | PubMed |
| Interactions Between E3 Ubiquitin Ligases and Deubiquitinases in AKT Regulation: Implications in Skeletal Muscle Homeostasis. | Cell Biochem Funct | 2026 | 42671015 | PubTator, text mining | PubMed |
| The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma (NPC) Differs by Somatostatin Receptor 2 (SSTR2) Expression. | Cancer Med | 2026 | 42670259 | PubTator, text mining | PubMed |
| Distinct mutational landscapes for germline and somatic cancer variants in forty tumor suppressor genes. | Am J Hum Genet | 2026 | 42641600 | PubTator, text mining | PubMed |
| The UVA-induced single-base mutational signature of CX-5461 in human cells. | Nucleic Acids Res | 2026 | 42639791 | PubTator, text mining | PubMed |
| Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation. | Adv Sci (Weinh) | 2026 | 42627676 | PubTator, text mining | PubMed |
| Deubiquitinating enzymes in kidney diseases: Molecular mechanisms, pathological roles and therapeutic opportunities (Review). | Mol Med Rep | 2026 | 42627060 | PubTator, text mining | PubMed |
1 to 10 of 3,467
See all 3,467 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1540
GET https://conductscience.org/api/genes/v1/1540/patents?page=2