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Gene · 155

ADRB3: adrenoceptor beta 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADRB3: adrenoceptor beta 3. Genes, record 155. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/155

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Gene

Symbol
ADRB3
HGNC
Name
adrenoceptor beta 3
HGNC
NCBI Gene ID
155
NCBI Gene
HGNC ID
HGNC:288
HGNC
Ensembl
ENSG00000188778
NCBI Gene
Aliases
BETA3AR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P13945Beta-3 adrenergic receptor4082Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436853P13945Espacenet
EP 4641201 A22025-10-296649P13945Espacenet
JP 2025529142 A2025-09-04338P13945Espacenet
US 12371689 B22025-07-29338P13945Espacenet
JP 2025517969 A2025-06-126649P13945Espacenet
JP 2025062604 A2025-04-143473P13945Espacenet
JP 2025062604 A2025-04-143474P13945Espacenet
US 11673938 B22023-06-134P13945Espacenet
US 11446398 B22022-09-203473P13945Espacenet
US 11446398 B22022-09-203474P13945Espacenet

1 to 10 of 60

See all 60 patents

Drugs33

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIBEGRONCHEMBL1193948Beta-3 adrenergic receptor agonistAGONISTChEMBL
AMIBEGRON HYDROCHLORIDECHEMBL545437Beta-3 adrenergic receptor agonistAGONISTChEMBL
CARTEOLOLCHEMBL839Adrenergic receptor beta antagonistANTAGONISTChEMBL
CARTEOLOL HYDROCHLORIDECHEMBL1201002Adrenergic receptor beta antagonistANTAGONISTChEMBL
CARVEDILOLCHEMBL723Adrenergic receptor beta antagonistANTAGONISTChEMBL
CARVEDILOL PHOSPHATECHEMBL1201167Adrenergic receptor beta antagonistANTAGONISTChEMBL
DILEVALOLCHEMBL27193Adrenergic receptor beta antagonistANTAGONISTChEMBL
DILEVALOL HYDROCHLORIDECHEMBL1204165Adrenergic receptor beta antagonistANTAGONISTChEMBL
DIPIVEFRINCHEMBL1201262Adrenergic receptor agonistAGONISTChEMBL
DIPIVEFRIN HYDROCHLORIDECHEMBL1200833Adrenergic receptor agonistAGONISTChEMBL

1 to 10 of 33

See all 33 drugs

Trials522

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,817

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADRB3 papersNewest fiscal year
R01DK097441Molecular mechanisms of UCP1-independent pathways in metabolic health232025
P30DK020572Michigan Diabetes Research Center (MDRC)162025
P30DK036836Diabetes Research Center162025
P30DK026687New York Obesity Research Center112025
R01DK062292Analysis of Cellular Plasticity in White Adipose Tissue.102025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)92025
ZIADK075116Physiological Responses to Activation of Human Brown Adipose Tissue92025
ZIADK075112The Molecular, Cellular, and Genetic characterization of Human Adipose Tissue and its Role in Metabolism82025
ZIADK075115Mechanisms Underlying Adipose Tissue Thermogenesis82025
P30CA016672Cancer Center Support Grant72025

1 to 10 of 1,817Source NIH's project files

See all 1,817 nih grants

Papers3,802

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Delayed late ventricular depolarization is associated with inflammation in epicardial Fat Among females: a New avenue in cardiac electrophysiology.Front Cardiovasc Med202642769221PubTator, text miningPubMed
ADRB3, LEPR, FTO and PPARG variants contribute to obesity-related metabolic syndrome in Brazilian adults: a polygenic risk score approach.Int J Obes (Lond)202642768086PubTator, text miningPubMed
Potential roles of β3-adrenergic receptor in heart rate regulation via sinus node activity and local adipocyte metabolism.J Physiol Sci202642759187PubTator, text miningPubMed
Comparative analysis of infarct-reducing properties of ß1 -, ß2 -, and ß3 -adrenergicreceptor ligands in ischemia and reperfusion of the heart.Pharmacology202642743088PubTator, text miningPubMed
Through beta2 or not through beta2-That's the question.Cell Metab202642679789PubTator, text miningPubMed
cAMP and cGMP pathways modulate spontaneous contractile activity in human seminal vesicle smooth muscle.Auton Neurosci202642679515PubTator, text miningPubMed
Sex-Specific Associations Between MTHFR, PPARG and ADRB3 Polymorphisms, Habitual Nutrient Intake and Metabolic Risk in Obesity: A Cross-Sectional Single-Centre Study.Nutrients202642588145PubTator, text miningPubMed
Beta2-adrenergic stimulation by fenoterol increases energy expenditure without activating human brown adipose tissue.Cell Metab202642586060PubTator, text miningPubMed
The impact of FTO and ADRB3 gene variants, physical activity and proper diet on weight gain and perinatal outcomes in pregnant women with obesity.J Appl Genet202642552455PubTator, text miningPubMed
Exploring β3-Adrenergic Receptor, HIF-1α, and CD31 Interplay in the Microenvironment of Atypical Melanocytic Lesions.Dermatopathology (Basel)202642496237PubTator, text miningPubMed

1 to 10 of 3,802

See all 3,802 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/155

GET https://conductscience.org/api/genes/v1/155/patents?page=2