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Gene · 1551

CYP3A7: cytochrome P450 family 3 subfamily A member 7

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CYP3A7: cytochrome P450 family 3 subfamily A member 7. Genes, record 1551. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1551

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Gene

Symbol
CYP3A7
HGNC
Name
cytochrome P450 family 3 subfamily A member 7
HGNC
NCBI Gene ID
1551
NCBI Gene
HGNC ID
HGNC:2640
HGNC
Ensembl
ENSG00000160870
NCBI Gene
Aliases
CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA, P450HLp2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P24462Cytochrome P450 3A75032Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-296042P24462Espacenet
JP 2025529142 A2025-09-041193P24462Espacenet
US 12371689 B22025-07-291193P24462Espacenet
JP 2025517969 A2025-06-126042P24462Espacenet
JP 2024128028 A2024-09-207P24462Espacenet
US 11760977 B22023-09-197P24462Espacenet
US 11685901 B22023-06-277P24462Espacenet
JP 2022153580 A2022-10-127P24462Espacenet
US 11446398 B22022-09-2022068P24462Espacenet
US 11400116 B22022-08-02239P24462Espacenet

1 to 10 of 26

See all 26 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COBICISTATCHEMBL2095208Cytochrome P450 3A inhibitorINHIBITORChEMBL
RITONAVIRCHEMBL163Cytochrome P450 3A inhibitorINHIBITORChEMBL

Trials513

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants803

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCYP3A7 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)62025
R01HD081299Ontogeny of drug transport62025
R35GM118041Regulation of xenobiotic receptors PXR and CAR, and CYP3A: implications in drug disposition62025
T32GM008425Indiana University Comprehensive Training in Clinical Pharmacology62025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)52025
R35GM140845Expression genetics of pharmacogenes52025
UM1AI068632IMPAACT Leadership Group52025
ZIABC005562Xenobiotic receptors52025
P30DK026743UCSF Liver Center42025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment42025

1 to 10 of 803Source NIH's project files

See all 803 nih grants

Papers1,325

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Submicellar aggregates of deoxycholate and glycodeoxycholate suppress in vitro CYP3A oxidation via membrane perturbation.Drug Metab Dispos202642822376PubTator, text miningPubMed
Role of CYP3A5 and CYP3A4 in the metabolism and toxicity of 10-hydroxyl mesaconitine, a new potential toxicity marker of Radix Aconiti Lateralis Preparata (Fuzi), in vitro and in vivo.Drug Metab Dispos202642456275PubTator, text miningPubMed
Contribution of cytochrome P450-mediated metabolism to clavulanic acid-induced cytotoxicity in TK6-derived cytochrome P450-overexpressing cell lines.Sci Rep202642449129PubTator, text miningPubMed
Hyocholic acids: Third bile acids for neonatal health.Trends Mol Med202642399159PubTator, text miningPubMed
A CYP3A7 metabolically competent human induced pluripotent stem cell-derived hepatocyte-like cell (hHLC3A7) model for drug safety assessment in the newborn.Drug Metab Dispos202642224858PubTator, text miningPubMed
Hyocholic acids shape neonatal immune tolerance and microbiota assembly.Cell Metab202642167251PubTator, text miningPubMed
Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone-Binding Globulin Expression.Basic Clin Pharmacol Toxicol202641789448PubTator, text miningPubMed
A cell atlas of multiple liver organoids and the fetal liver based on scRNA-seq.iScience202641736863PubTator, text miningPubMed
Genetic Modulation of Mercury Exposure on Perinatal and Birth Outcomes: A Systematic Review and Meta-Analysis of Gene-Environment Interactions.J Xenobiot202641718271PubTator, text miningPubMed
Altered gene expression and activity of human placental drug-metabolizing cytochrome P450 enzymes across gestation.Biochem Pharmacol202641679666PubTator, text miningPubMed

1 to 10 of 1,325

See all 1,325 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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