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CYP3A4: cytochrome P450 family 3 subfamily A member 4

1 protein, 78 patents, 3 drugs, 513 trials, 7,881 NIH grants and 38,505 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCYP3A4HGNC
Namecytochrome P450 family 3 subfamily A member 4HGNC
NCBI Gene ID1576NCBI Gene
HGNC IDHGNC:2637HGNC
EnsemblENSG00000160868NCBI Gene
AliasesCP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1, VDDR3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08684Cytochrome P450 3A4503122Ensembl, GeneID, HGNCUniProt

Patents 78

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026143185 A12026-07-02367P08684Espacenet
EP 4759933 A22026-06-17105P08684Espacenet
EP 4685238 A22026-01-2822P08684Espacenet
JP 2026004568 A2026-01-1442909P08684Espacenet
EP 4650780 A22025-11-1919776P08684Espacenet
EP 4641201 A22025-10-2925699P08684Espacenet
JP 2025529142 A2025-09-041190P08684Espacenet
EP 4594342 A22025-08-06136P08684Espacenet
US 12371689 B22025-07-291190P08684Espacenet
JP 2025517969 A2025-06-1225699P08684Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COBICISTATCHEMBL2095208Cytochrome P450 3A inhibitorINHIBITORChEMBL
RITONAVIRCHEMBL163Cytochrome P450 3A inhibitorINHIBITORChEMBL
TABIMORELINCHEMBL281764Cytochrome P450 3A4 inhibitorINHIBITORChEMBL

Trials 513

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07261085RITONAVIRClinicalTrials.gov
NCT07072793RITONAVIR2026-01-12ClinicalTrials.gov
NCT06799650RITONAVIRPHASE2ClinicalTrials.gov
NCT06735300RITONAVIRClinicalTrials.gov
NCT06710990RITONAVIRPHASE1ClinicalTrials.gov
NCT06610643RITONAVIRClinicalTrials.gov
NCT06428045RITONAVIRPHASE1ClinicalTrials.gov
NCT06291831RITONAVIR2025-08-19ClinicalTrials.gov
NCT06139796RITONAVIRPHASE1/PHASE2ClinicalTrials.gov
NCT06016556RITONAVIR2025-04-29ClinicalTrials.gov

NIH grants 7881

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA021765Cancer Center Support Grant (CCSG)1142,025NIH's project files
P30CA008748Cancer Center Support Grant832,025NIH's project files
P30CA016672Cancer Center Support Grant832,025NIH's project files
P30DK026743UCSF Liver Center632,025NIH's project files
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment512,025NIH's project files
P30CA006973Regional Oncology Research Center482,025NIH's project files
T32GM008425Indiana University Comprehensive Training in Clinical Pharmacology482,025NIH's project files
UM1AI068632IMPAACT Leadership Group482,025NIH's project files
UM1AI068636Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections472,025NIH's project files
UM1AI068634Statistical and Data Management Center (SDMC), Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG)432,025NIH's project files

Papers 38505

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822636PubTator, text miningPubMed
42822376PubTator, text miningPubMed
42820847PubTator, text miningPubMed
42818036PubTator, text miningPubMed
42815442PubTator, text miningPubMed
42814376PubTator, text miningPubMed
42813501PubTator, text miningPubMed
42811266PubTator, text miningPubMed
42811096PubTator, text miningPubMed
42809305PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license