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CYP3A5: cytochrome P450 family 3 subfamily A member 5

1 protein, 35 patents, 2 drugs, 513 trials, 2,353 NIH grants and 7,091 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCYP3A5HGNC
Namecytochrome P450 family 3 subfamily A member 5HGNC
NCBI Gene ID1577NCBI Gene
HGNC IDHGNC:2638HGNC
EnsemblENSG00000106258NCBI Gene
AliasesCP35, CYPIIIA5, P450PCN3, PCN3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P20815Cytochrome P450 3A55026Ensembl, GeneID, HGNCUniProt

Patents 35

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4685238 A22026-01-2840P20815Espacenet
JP 2026004568 A2026-01-1442918P20815Espacenet
EP 4641201 A22025-10-29406P20815Espacenet
EP 4594342 A22025-08-06120P20815Espacenet
JP 2025517969 A2025-06-12406P20815Espacenet
US 11781164 B22023-10-1040P20815Espacenet
US 11446398 B22022-09-2022064P20815Espacenet
US 11400116 B22022-08-02244P20815Espacenet
JP 2022524081 A2022-04-27125035P20815Espacenet
US 11078247 B22021-08-032831P20815Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COBICISTATCHEMBL2095208Cytochrome P450 3A inhibitorINHIBITORChEMBL
RITONAVIRCHEMBL163Cytochrome P450 3A inhibitorINHIBITORChEMBL

Trials 513

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07261085RITONAVIRClinicalTrials.gov
NCT07072793RITONAVIR2026-01-12ClinicalTrials.gov
NCT06799650RITONAVIRPHASE2ClinicalTrials.gov
NCT06735300RITONAVIRClinicalTrials.gov
NCT06710990RITONAVIRPHASE1ClinicalTrials.gov
NCT06610643RITONAVIRClinicalTrials.gov
NCT06428045RITONAVIRPHASE1ClinicalTrials.gov
NCT06291831RITONAVIR2025-08-19ClinicalTrials.gov
NCT06139796RITONAVIRPHASE1/PHASE2ClinicalTrials.gov
NCT06016556RITONAVIR2025-04-29ClinicalTrials.gov

NIH grants 2353

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA021765Cancer Center Support Grant (CCSG)422,025NIH's project files
T32GM008425Indiana University Comprehensive Training in Clinical Pharmacology262,025NIH's project files
R01AI077505Pharmacogenomics of HIV Therapy162,025NIH's project files
UM1AI068634Statistical and Data Management Center (SDMC), Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG)152,025NIH's project files
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment142,025NIH's project files
P30DK026743UCSF Liver Center132,025NIH's project files
UM1AI068636Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections132,025NIH's project files
P30CA008748Cancer Center Support Grant122,025NIH's project files
R35GM118041Regulation of xenobiotic receptors PXR and CAR, and CYP3A: implications in drug disposition122,025NIH's project files
UM1AI068632IMPAACT Leadership Group112,025NIH's project files

Papers 7091

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822636PubTator, text miningPubMed
42811819PubTator, text miningPubMed
42807650PubTator, text miningPubMed
42797533PubTator, text miningPubMed
42797446PubTator, text miningPubMed
42783788PubTator, text miningPubMed
42783501PubTator, text miningPubMed
42782834PubTator, text miningPubMed
42760608PubTator, text miningPubMed
42756309PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license