Gene · 158
ADSL: adenylosuccinate lyase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ADSL: adenylosuccinate lyase. Genes, record 158. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/158
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P30566 | Adenylosuccinate lyase | 484 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 358 | P30566 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 36731 | P30566 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 23657 | P30566 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 23657 | P30566 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 2912 | P30566 | Espacenet |
| JP 2023521663 A | 2023-05-25 | 357 | P30566 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 2912 | P30566 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 105883 | P30566 | Espacenet |
| US 11273161 B2 | 2022-03-15 | 13 | P30566 | Espacenet |
| JP 2021530985 A | 2021-11-18 | 465 | P30566 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants951
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ADSL papers | Newest fiscal year |
|---|---|---|---|
| P30CA046934 | University of Colorado Cancer Center Support Grant | 8 | 2025 |
| P30ES019776 | HERCULES: Exposome Research Center | 4 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 4 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 4 | 2025 |
| T32GM007526 | Medical Genetics Research Fellowship Program | 4 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 3 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 3 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 3 | 2025 |
| R01CA256833 | BBOX1 is a Novel Oncogenic Driver in Triple Negative Breast Cancer | 3 | 2025 |
| R01DK046492 | Engineered Glucose Metabolism in Insulin Secreting Cells | 3 | 2025 |
1 to 10 of 951Source NIH's project files
See all 951 nih grantsPapers1,345
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identification of key genes and mechanistic exploration of metabolic reprogramming in osteoporosis. | J Int Med Res | 2026 | 42805907 | PubTator, text mining | PubMed |
| Amylosucrase as a Versatile Biocatalyst for Next-Generation Functional Ingredients: Starch Modification and Glycoside Synthesis. | Compr Rev Food Sci Food Saf | 2026 | 42746754 | PubTator, text mining | PubMed |
| Adenylosuccinate lyase in pancreatic ductal adenocarcinoma chemoresistance: from purine metabolism to metabolic vulnerability. | Cancer Drug Resist | 2026 | 42729694 | PubTator, text mining | PubMed |
| Genomic insights into Aeromonas infections in diarrheal patients: high diversity, emerging resistance, and potential outbreak in Beijing. | Front Microbiol | 2026 | 42707199 | PubTator, text mining | PubMed |
| A novel homozygous variant causing fatal neonatal adenylosuccinate lyase (ADSL) deficiency presenting with respiratory failure and encephalopathy. | Matern Health Neonatol Perinatol | 2026 | 42576248 | PubTator, text mining | PubMed |
| ADSL drives fumarate mediated scrib-rictor complex formation to promote metastasis dissemination in triple-negative breast cancer. | Mol Cancer | 2026 | 42472815 | PubTator, text mining | PubMed |
| A Propionate Metabolism-Based Gene Signature Reveals Immunogenomic and Transcriptomic Determinants of Prognosis in Glioblastoma Through Multiomics Integration. | Hum Mutat | 2026 | 42147808 | PubTator, text mining | PubMed |
| Integrated multi-dimensional modeling of non-model bacteria identifies engineering targets for acarbose biosynthesis optimization. | Cell Rep Methods | 2026 | 42055003 | PubTator, text mining | PubMed |
| Effect of the intestinal microbiota on TH17 cell-derived cytokines in the context of intestinal inflammation. | Semin Immunopathol | 2026 | 41925908 | PubTator, text mining | PubMed |
| The oncogenic control of nucleotide synthesis. | Oncogenesis | 2026 | 41881963 | PubTator, text mining | PubMed |
1 to 10 of 1,345
See all 1,345 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/158
GET https://conductscience.org/api/genes/v1/158/patents?page=2