ConductScience.org, home

Gene · 158

ADSL: adenylosuccinate lyase

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. ADSL: adenylosuccinate lyase. Genes, record 158. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/158

On this page

Gene

Symbol
ADSL
HGNC
Name
adenylosuccinate lyase
HGNC
NCBI Gene ID
158
NCBI Gene
HGNC ID
HGNC:291
HGNC
Ensembl
ENSG00000239900
NCBI Gene
Aliases
AMPS, ASASE, ASL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30566Adenylosuccinate lyase4844Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21358P30566Espacenet
JP 2026004568 A2026-01-1436731P30566Espacenet
EP 4641201 A22025-10-2923657P30566Espacenet
JP 2025517969 A2025-06-1223657P30566Espacenet
JP 2025062604 A2025-04-142912P30566Espacenet
JP 2023521663 A2023-05-25357P30566Espacenet
US 11446398 B22022-09-202912P30566Espacenet
JP 2022524081 A2022-04-27105883P30566Espacenet
US 11273161 B22022-03-1513P30566Espacenet
JP 2021530985 A2021-11-18465P30566Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants951

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADSL papersNewest fiscal year
P30CA046934University of Colorado Cancer Center Support Grant82025
P30ES019776HERCULES: Exposome Research Center42025
P40OD010440Caenorhabditis Genetics Center42025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control42025
T32GM007526Medical Genetics Research Fellowship Program42025
P30AI027763UCSF-Bay Area Center for AIDS Research32025
P30CA013148Comprehensive Cancer Center Support Grant32025
P30CA023108Cancer Center Support Grant32025
R01CA256833BBOX1 is a Novel Oncogenic Driver in Triple Negative Breast Cancer32025
R01DK046492Engineered Glucose Metabolism in Insulin Secreting Cells32025

1 to 10 of 951Source NIH's project files

See all 951 nih grants

Papers1,345

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of key genes and mechanistic exploration of metabolic reprogramming in osteoporosis.J Int Med Res202642805907PubTator, text miningPubMed
Amylosucrase as a Versatile Biocatalyst for Next-Generation Functional Ingredients: Starch Modification and Glycoside Synthesis.Compr Rev Food Sci Food Saf202642746754PubTator, text miningPubMed
Adenylosuccinate lyase in pancreatic ductal adenocarcinoma chemoresistance: from purine metabolism to metabolic vulnerability.Cancer Drug Resist202642729694PubTator, text miningPubMed
Genomic insights into Aeromonas infections in diarrheal patients: high diversity, emerging resistance, and potential outbreak in Beijing.Front Microbiol202642707199PubTator, text miningPubMed
A novel homozygous variant causing fatal neonatal adenylosuccinate lyase (ADSL) deficiency presenting with respiratory failure and encephalopathy.Matern Health Neonatol Perinatol202642576248PubTator, text miningPubMed
ADSL drives fumarate mediated scrib-rictor complex formation to promote metastasis dissemination in triple-negative breast cancer.Mol Cancer202642472815PubTator, text miningPubMed
A Propionate Metabolism-Based Gene Signature Reveals Immunogenomic and Transcriptomic Determinants of Prognosis in Glioblastoma Through Multiomics Integration.Hum Mutat202642147808PubTator, text miningPubMed
Integrated multi-dimensional modeling of non-model bacteria identifies engineering targets for acarbose biosynthesis optimization.Cell Rep Methods202642055003PubTator, text miningPubMed
Effect of the intestinal microbiota on TH17 cell-derived cytokines in the context of intestinal inflammation.Semin Immunopathol202641925908PubTator, text miningPubMed
The oncogenic control of nucleotide synthesis.Oncogenesis202641881963PubTator, text miningPubMed

1 to 10 of 1,345

See all 1,345 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/158

GET https://conductscience.org/api/genes/v1/158/patents?page=2