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Gene · 1585

CYP11B2: cytochrome P450 family 11 subfamily B member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CYP11B2: cytochrome P450 family 11 subfamily B member 2. Genes, record 1585. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1585

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Gene

Symbol
CYP11B2
HGNC
Name
cytochrome P450 family 11 subfamily B member 2
HGNC
NCBI Gene ID
1585
NCBI Gene
HGNC ID
HGNC:2592
HGNC
Ensembl
ENSG00000179142
NCBI Gene
Aliases
ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P19099Cytochrome P450 11B2, mitochondrial5037Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442840P19099Espacenet
EP 4641201 A22025-10-295270P19099Espacenet
JP 2025517969 A2025-06-125270P19099Espacenet
US 11446398 B22022-09-2021900P19099Espacenet
JP 2022524081 A2022-04-27124871P19099Espacenet
US 11078247 B22021-08-032799P19099Espacenet
JP 2019054813 A2019-04-11223275P19099Espacenet
JP 2017121241 A2017-07-13223275P19099Espacenet
WO 2016164476 A22016-10-136P19099Espacenet
JP 2015516143 A2015-06-08223275P19099Espacenet

1 to 10 of 15

See all 15 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
LEVOKETOCONAZOLECHEMBL295698Cytochrome P450 11B2 inhibitorINHIBITOR

Source ChEMBL

Trials5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03621280LEVOKETOCONAZOLEPHASE32025-06-19ClinicalTrials.gov
NCT03277690LEVOKETOCONAZOLEPHASE32022-11-08ClinicalTrials.gov
NCT01838551LEVOKETOCONAZOLEPHASE32021-04-19ClinicalTrials.gov
NCT00622089LEVOKETOCONAZOLEPHASE2/PHASE3ClinicalTrials.gov
NCT00494663LEVOKETOCONAZOLEPHASE2ClinicalTrials.gov

NIH grants1,120

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCYP11B2 papersNewest fiscal year
R01DK043140Mechanisms Leading to Adrenal Zonation612025
U54GM115428Mississippi Center for Clinical and Translational Research322025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028112025
R01GM086596Activation of androgen biosynthesis and drug metabolism by cytochrome b5102025
R01DK062027Mechanisms of Adrenal Differentiation82025
UL1TR001863Yale Clinical and Translational Science Award52025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
R01DK115392Unrecognized Primary Aldosteronism as a Pathogenic Mechanism for Chronic Kidney Disease in Diabetes42025
R01HL155834Primary Aldosteronism Subtypes: Pathophysiology and Steroid Signatures42025
R35GM133375Structural regulation of Class-I and Class-II cytochrome P450 enzymes42025

1 to 10 of 1,120Source NIH's project files

See all 1,120 nih grants

Papers3,065

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Deciphering aldosterone deficiency and pseudodeficiency in infancy by targeted GC-MS urinary steroid metabotyping.J Steroid Biochem Mol Biol202742603653PubTator, text miningPubMed
Emerging therapeutics in hypertension: Evidence, clinical readiness, and implementation.Curr Probl Cardiol202642810479PubTator, text miningPubMed
Baxdrostat (Baxfendy®), a first-in-class aldosterone synthase inhibitor approved for adults with uncontrolled hypertension.Med Chem Res202642809094PubTator, text miningPubMed
Aldosterone Synthase Inhibition in Kidney Transplantation: Class Rationale, Translational Promise, and the Limits of Current Evidence-Response to Singh et al.Clin Transplant202642804518PubTator, text miningPubMed
Aldosterone Synthase Inhibitors: Emerging Therapeutic Strategies in Resistant Hypertension.Life (Basel)202642795360PubTator, text miningPubMed
Results from the Phase 2 Explore-CKD Trial of lorundrostat, a novel aldosterone synthase inhibitor, in participants with uncontrolled hypertension, chronic kidney disease, and albuminuria.Kidney Int202642778148PubTator, text miningPubMed
Identification of a novel small-molecule compound that suppresses depolarization-induced CYP11B2 expression and aldosterone production in KCNJ5 mutant adrenocortical cells.Biochem Biophys Res Commun202642777615PubTator, text miningPubMed
Clinical utilization of CYP17A1 and CYP11B2 in evaluating cortisol- and aldosterone-producing adrenal nodules.Hum Pathol202642772699PubTator, text miningPubMed
ADRB3, LEPR, FTO and PPARG variants contribute to obesity-related metabolic syndrome in Brazilian adults: a polygenic risk score approach.Int J Obes (Lond)202642768086PubTator, text miningPubMed
A Review Highlighting Emerging Frontiers in Hypertension Management: Integrating Novel Therapeutics and Holistic Approaches.Curr Hypertens Rev202642736668PubTator, text miningPubMed

1 to 10 of 3,065

See all 3,065 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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