Gene · 1585
CYP11B2: cytochrome P450 family 11 subfamily B member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CYP11B2: cytochrome P450 family 11 subfamily B member 2. Genes, record 1585. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1585
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P19099 | Cytochrome P450 11B2, mitochondrial | 503 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents15
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 42840 | P19099 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5270 | P19099 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5270 | P19099 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 21900 | P19099 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 124871 | P19099 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 2799 | P19099 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 223275 | P19099 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 223275 | P19099 | Espacenet |
| WO 2016164476 A2 | 2016-10-13 | 6 | P19099 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 223275 | P19099 | Espacenet |
1 to 10 of 15
See all 15 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| LEVOKETOCONAZOLE | CHEMBL295698 | Cytochrome P450 11B2 inhibitor | INHIBITOR |
Source ChEMBL
Trials5
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03621280 | LEVOKETOCONAZOLE | PHASE3 | 2025-06-19 | ClinicalTrials.gov |
| NCT03277690 | LEVOKETOCONAZOLE | PHASE3 | 2022-11-08 | ClinicalTrials.gov |
| NCT01838551 | LEVOKETOCONAZOLE | PHASE3 | 2021-04-19 | ClinicalTrials.gov |
| NCT00622089 | LEVOKETOCONAZOLE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT00494663 | LEVOKETOCONAZOLE | PHASE2 | ClinicalTrials.gov |
NIH grants1,120
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CYP11B2 papers | Newest fiscal year |
|---|---|---|---|
| R01DK043140 | Mechanisms Leading to Adrenal Zonation | 61 | 2025 |
| U54GM115428 | Mississippi Center for Clinical and Translational Research | 32 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 11 | 2025 |
| R01GM086596 | Activation of androgen biosynthesis and drug metabolism by cytochrome b5 | 10 | 2025 |
| R01DK062027 | Mechanisms of Adrenal Differentiation | 8 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 4 | 2025 |
| R01DK115392 | Unrecognized Primary Aldosteronism as a Pathogenic Mechanism for Chronic Kidney Disease in Diabetes | 4 | 2025 |
| R01HL155834 | Primary Aldosteronism Subtypes: Pathophysiology and Steroid Signatures | 4 | 2025 |
| R35GM133375 | Structural regulation of Class-I and Class-II cytochrome P450 enzymes | 4 | 2025 |
1 to 10 of 1,120Source NIH's project files
See all 1,120 nih grantsPapers3,065
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Deciphering aldosterone deficiency and pseudodeficiency in infancy by targeted GC-MS urinary steroid metabotyping. | J Steroid Biochem Mol Biol | 2027 | 42603653 | PubTator, text mining | PubMed |
| Emerging therapeutics in hypertension: Evidence, clinical readiness, and implementation. | Curr Probl Cardiol | 2026 | 42810479 | PubTator, text mining | PubMed |
| Baxdrostat (Baxfendy®), a first-in-class aldosterone synthase inhibitor approved for adults with uncontrolled hypertension. | Med Chem Res | 2026 | 42809094 | PubTator, text mining | PubMed |
| Aldosterone Synthase Inhibition in Kidney Transplantation: Class Rationale, Translational Promise, and the Limits of Current Evidence-Response to Singh et al. | Clin Transplant | 2026 | 42804518 | PubTator, text mining | PubMed |
| Aldosterone Synthase Inhibitors: Emerging Therapeutic Strategies in Resistant Hypertension. | Life (Basel) | 2026 | 42795360 | PubTator, text mining | PubMed |
| Results from the Phase 2 Explore-CKD Trial of lorundrostat, a novel aldosterone synthase inhibitor, in participants with uncontrolled hypertension, chronic kidney disease, and albuminuria. | Kidney Int | 2026 | 42778148 | PubTator, text mining | PubMed |
| Identification of a novel small-molecule compound that suppresses depolarization-induced CYP11B2 expression and aldosterone production in KCNJ5 mutant adrenocortical cells. | Biochem Biophys Res Commun | 2026 | 42777615 | PubTator, text mining | PubMed |
| Clinical utilization of CYP17A1 and CYP11B2 in evaluating cortisol- and aldosterone-producing adrenal nodules. | Hum Pathol | 2026 | 42772699 | PubTator, text mining | PubMed |
| ADRB3, LEPR, FTO and PPARG variants contribute to obesity-related metabolic syndrome in Brazilian adults: a polygenic risk score approach. | Int J Obes (Lond) | 2026 | 42768086 | PubTator, text mining | PubMed |
| A Review Highlighting Emerging Frontiers in Hypertension Management: Integrating Novel Therapeutics and Holistic Approaches. | Curr Hypertens Rev | 2026 | 42736668 | PubTator, text mining | PubMed |
1 to 10 of 3,065
See all 3,065 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1585
GET https://conductscience.org/api/genes/v1/1585/patents