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CYP17A1: cytochrome P450 family 17 subfamily A member 1

1 protein, 31 patents, 6 drugs, 327 trials, 2,936 NIH grants and 6,667 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCYP17A1HGNC
Namecytochrome P450 family 17 subfamily A member 1HGNC
NCBI Gene ID1586NCBI Gene
HGNC IDHGNC:2593HGNC
EnsemblENSG00000148795NCBI Gene
AliasesCPT7, CYP17, P450C17, S17AHNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P05093Steroid 17-alpha-hydroxylase/17,20 lyase50817Ensembl, GeneID, HGNCUniProt

Patents 31

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442841P05093Espacenet
EP 4650780 A22025-11-198685P05093Espacenet
JP 2025147176 A2025-10-063833P05093Espacenet
JP 2025529142 A2025-09-046087P05093Espacenet
US 12371689 B22025-07-296087P05093Espacenet
JP 2025517970 A2025-06-128685P05093Espacenet
JP 2025028160 A2025-02-283833P05093Espacenet
KR 1020250010750 A2025-01-213833P05093Espacenet
JP 2024109657 A2024-08-143840P05093Espacenet
JP 2022553763 A2022-12-267P05093Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABIRATERONECHEMBL254328Cytochrome P450 17A1 inhibitorINHIBITORChEMBL
ABIRATERONE ACETATECHEMBL271227Cytochrome P450 17A1 inhibitorINHIBITORChEMBL
GALETERONECHEMBL2105738Cytochrome P450 17A1 inhibitorINHIBITORChEMBL
LEVOKETOCONAZOLECHEMBL295698Cytochrome P450 17A1 inhibitorINHIBITORChEMBL
ORTERONELCHEMBL1921976Cytochrome P450 17A1 inhibitorINHIBITORChEMBL
SEVITERONELCHEMBL3264610Cytochrome P450 17A1 inhibitorINHIBITORChEMBL

Trials 327

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07570979ABIRATERONEPHASE1ClinicalTrials.gov
NCT07553988ABIRATERONEPHASE2ClinicalTrials.gov
NCT07406282ABIRATERONE ACETATEClinicalTrials.gov
NCT07299292ABIRATERONEPHASE2ClinicalTrials.gov
NCT07237269ABIRATERONEPHASE2ClinicalTrials.gov
NCT07226986ABIRATERONEPHASE1/PHASE2ClinicalTrials.gov
NCT07190300ABIRATERONEPHASE1/PHASE2ClinicalTrials.gov
NCT07154914ABIRATERONEClinicalTrials.gov
NCT07140900ABIRATERONEPHASE1ClinicalTrials.gov
NCT07104617ABIRATERONE ACETATEPHASE1/PHASE2ClinicalTrials.gov

NIH grants 2936

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P50CA097186The Pacific Northwest Prostate Cancer SPORE442,025NIH's project files
P30CA008748Cancer Center Support Grant432,025NIH's project files
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer412,025NIH's project files
P30CA006973Regional Oncology Research Center402,025NIH's project files
R01DK043140Mechanisms Leading to Adrenal Zonation392,025NIH's project files
R01GM086596Activation of androgen biosynthesis and drug metabolism by cytochrome b5322,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology312,025NIH's project files
P30CA016672Cancer Center Support Grant282,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant192,025NIH's project files
R35GM118145Nanoscale Approaches to Understanding Membrane Protein Function172,025NIH's project files

Papers 6667

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824042PubTator, text miningPubMed
42821636PubTator, text miningPubMed
42813898PubTator, text miningPubMed
42813264PubTator, text miningPubMed
42772699PubTator, text miningPubMed
42765541PubTator, text miningPubMed
42737662PubTator, text miningPubMed
42733515PubTator, text miningPubMed
42723272PubTator, text miningPubMed
42721119PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license