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CYP19A1: cytochrome P450 family 19 subfamily A member 1

1 protein, 46 patents, 7 drugs, 1,056 trials, 7,274 NIH grants and 23,313 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCYP19A1HGNC
Namecytochrome P450 family 19 subfamily A member 1HGNC
NCBI Gene ID1588NCBI Gene
HGNC IDHGNC:2594HGNC
EnsemblENSG00000137869NCBI Gene
AliasesARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM, aromataseNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P11511Aromatase50311Ensembl, GeneID, HGNCUniProt

Patents 46

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442842P11511Espacenet
JP 2026004568 A2026-01-1442843P11511Espacenet
JP 2026004568 A2026-01-1442844P11511Espacenet
JP 2026004568 A2026-01-1442855P11511Espacenet
EP 4641201 A22025-10-2911908P11511Espacenet
JP 2025529142 A2025-09-041180P11511Espacenet
US 12371689 B22025-07-291180P11511Espacenet
JP 2025517969 A2025-06-1211908P11511Espacenet
US 11446398 B22022-09-2021902P11511Espacenet
US 11446398 B22022-09-2021903P11511Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMINOGLUTETHIMIDECHEMBL488Cytochrome P450 19A1 inhibitorINHIBITORChEMBL
ANASTROZOLECHEMBL1399Cytochrome P450 19A1 inhibitorINHIBITORChEMBL
EXEMESTANECHEMBL1200374Cytochrome P450 19A1 inhibitorINHIBITORChEMBL
FADROZOLECHEMBL9298Cytochrome P450 19A1 inhibitorINHIBITORChEMBL
FADROZOLE HYDROCHLORIDECHEMBL468419Cytochrome P450 19A1 inhibitorINHIBITORChEMBL
LETROZOLECHEMBL1444Cytochrome P450 19A1 inhibitorINHIBITORChEMBL
TESTOLACTONECHEMBL1571Cytochrome P450 19A1 inhibitorINHIBITORChEMBL

Trials 1056

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604571LETROZOLEPHASE1ClinicalTrials.gov
NCT07604272LETROZOLEPHASE1ClinicalTrials.gov
NCT07570966LETROZOLEPHASE1/PHASE2ClinicalTrials.gov
NCT07492641LETROZOLEPHASE3ClinicalTrials.gov
NCT07492394LETROZOLEPHASE2ClinicalTrials.gov
NCT07448272LETROZOLEClinicalTrials.gov
NCT07425990LETROZOLEClinicalTrials.gov
NCT07401381LETROZOLEPHASE1ClinicalTrials.gov
NCT07395336EXEMESTANEPHASE2ClinicalTrials.gov
NCT07394946LETROZOLEPHASE2ClinicalTrials.gov

NIH grants 7274

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1392,025NIH's project files
P30CA016672Cancer Center Support Grant832,025NIH's project files
P30CA033572Cancer Center Support Grant572,025NIH's project files
P50CA116201Mayo Clinic Breast Cancer SPORE432,025NIH's project files
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant382,025NIH's project files
P30CA006973Regional Oncology Research Center362,025NIH's project files
P30CA016058Cancer Center Support Grant322,025NIH's project files
P30CA068485Cancer Center Support Grant312,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant302,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award282,025NIH's project files

Papers 23313

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821636PubTator, text miningPubMed
42821255PubTator, text miningPubMed
42819837PubTator, text miningPubMed
42813264PubTator, text miningPubMed
42811175PubTator, text miningPubMed
42797753PubTator, text miningPubMed
42794732PubTator, text miningPubMed
42793248PubTator, text miningPubMed
42790158PubTator, text miningPubMed
42786359PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license