Gene · 1589
CYP21A2: cytochrome P450 family 21 subfamily A member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CYP21A2: cytochrome P450 family 21 subfamily A member 2. Genes, record 1589. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1589
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P08686 | Steroid 21-hydroxylase | 495 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents66
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 42888 | P08686 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 42889 | P08686 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 42894 | P08686 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 19538 | P08686 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 25164 | P08686 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 3848 | P08686 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 3849 | P08686 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 3850 | P08686 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 25164 | P08686 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 19538 | P08686 | Espacenet |
1 to 10 of 66
See all 66 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,049
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CYP21A2 papers | Newest fiscal year |
|---|---|---|---|
| R01DK043140 | Mechanisms Leading to Adrenal Zonation | 18 | 2025 |
| R01GM086596 | Activation of androgen biosynthesis and drug metabolism by cytochrome b5 | 17 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| R01DK032083 | Multiple Autoantigens, Multiple Epitopes of Type 1 Diabetes | 8 | 2025 |
| U54GM115428 | Mississippi Center for Clinical and Translational Research | 8 | 2025 |
| KL2TR001854 | Institutional Career Development Core | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| T32ES007028 | Training Program in Environmental Toxicology | 4 | 2025 |
| K12HD000850 | Pediatric Scientist Development Program | 3 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
1 to 10 of 1,049Source NIH's project files
See all 1,049 nih grantsPapers3,802
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Adrenal Rest Tumors and the clinical course of gonadal dysfunction in adult men with Congenital Adrenal Hyperplasia caused by 21-Hydroxylase Deficiency: A single-center experience with long-term follow-up. | Endocrine | 2026 | 42804041 | PubTator, text mining | PubMed |
| Very-early-onset autosomal dominant polycystic kidney disease coexisting with congenital adrenal hyperplasia in a newborn: a case report. | Child Kidney Dis | 2026 | 42779582 | PubTator, text mining | PubMed |
| The importance of elevated basal 17-hydroxyprogesterone in the diagnosis of children with congenital adrenal hyperplasia. | J Med Biochem | 2026 | 42775055 | PubTator, text mining | PubMed |
| Leveraging Long-Read Sequencing to Bridge the Diagnostic and Equity Gaps in Differences of Sex Development (DSD). | J Clin Endocrinol Metab | 2026 | 42773944 | PubTator, text mining | PubMed |
| Xp21 contiguous gene deletion syndrome presenting as congenital adrenal hypoplasia: molecular diagnosis and clinical re-evaluation of a pedigree. | Front Endocrinol (Lausanne) | 2026 | 42729112 | PubTator, text mining | PubMed |
| Long-Read Sequencing Resolves Complex CYP21A2 Variants and Identifies 2+0 Carriers in 21-Hydroxylase Deficiency. | J Mol Diagn | 2026 | 42727689 | PubTator, text mining | PubMed |
| Case Report: unmasking pseudo-homozygosity in CYP21A2: intergenerational gene conversion expansion and the necessity of multimodal genetic testing. | Front Endocrinol (Lausanne) | 2026 | 42682406 | PubTator, text mining | PubMed |
| Clinical and genetic spectrum of classic congenital adrenal hyperplasia due to CYP21A2 mutations in a Taiwanese cohort. | Pediatr Neonatol | 2026 | 42680663 | PubTator, text mining | PubMed |
| A Comprehensive Pipeline for the Use of Short Read Next-Generation Sequencing (SR-NGS) in CYP21A2 Diagnostic Genotyping. | Curr Issues Mol Biol | 2026 | 42651824 | PubTator, text mining | PubMed |
| Prepubertal Screening for Testicular Adrenal Rest Tumors in Boys with Classic Congenital Adrenal Hyperplasia: Emerging Evidence and Practical Implications. | Children (Basel) | 2026 | 42650343 | PubTator, text mining | PubMed |
1 to 10 of 3,802
See all 3,802 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1589
GET https://conductscience.org/api/genes/v1/1589/patents?page=2