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Gene · 1589

CYP21A2: cytochrome P450 family 21 subfamily A member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CYP21A2: cytochrome P450 family 21 subfamily A member 2. Genes, record 1589. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1589

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Gene

Symbol
CYP21A2
HGNC
Name
cytochrome P450 family 21 subfamily A member 2
HGNC
NCBI Gene ID
1589
NCBI Gene
HGNC ID
HGNC:2600
HGNC
Ensembl
ENSG00000231852
NCBI Gene
Aliases
CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08686Steroid 21-hydroxylase4952Ensembl, GeneID, HGNC

Source UniProt

Patents66

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442888P08686Espacenet
JP 2026004568 A2026-01-1442889P08686Espacenet
JP 2026004568 A2026-01-1442894P08686Espacenet
EP 4650780 A22025-11-1919538P08686Espacenet
EP 4641201 A22025-10-2925164P08686Espacenet
JP 2025147176 A2025-10-063848P08686Espacenet
JP 2025147176 A2025-10-063849P08686Espacenet
JP 2025147176 A2025-10-063850P08686Espacenet
JP 2025517969 A2025-06-1225164P08686Espacenet
JP 2025517970 A2025-06-1219538P08686Espacenet

1 to 10 of 66

See all 66 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,049

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCYP21A2 papersNewest fiscal year
R01DK043140Mechanisms Leading to Adrenal Zonation182025
R01GM086596Activation of androgen biosynthesis and drug metabolism by cytochrome b5172025
P30CA008748Cancer Center Support Grant102025
R01DK032083Multiple Autoantigens, Multiple Epitopes of Type 1 Diabetes82025
U54GM115428Mississippi Center for Clinical and Translational Research82025
KL2TR001854Institutional Career Development Core42025
P30CA016672Cancer Center Support Grant42025
T32ES007028Training Program in Environmental Toxicology42025
K12HD000850Pediatric Scientist Development Program32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025

1 to 10 of 1,049Source NIH's project files

See all 1,049 nih grants

Papers3,802

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Adrenal Rest Tumors and the clinical course of gonadal dysfunction in adult men with Congenital Adrenal Hyperplasia caused by 21-Hydroxylase Deficiency: A single-center experience with long-term follow-up.
Endocrine202642804041PubTator, text miningPubMed
Very-early-onset autosomal dominant polycystic kidney disease coexisting with congenital adrenal hyperplasia in a newborn: a case report.Child Kidney Dis202642779582PubTator, text miningPubMed
The importance of elevated basal 17-hydroxyprogesterone in the diagnosis of children with congenital adrenal hyperplasia.J Med Biochem202642775055PubTator, text miningPubMed
Leveraging Long-Read Sequencing to Bridge the Diagnostic and Equity Gaps in Differences of Sex Development (DSD).J Clin Endocrinol Metab202642773944PubTator, text miningPubMed
Xp21 contiguous gene deletion syndrome presenting as congenital adrenal hypoplasia: molecular diagnosis and clinical re-evaluation of a pedigree.Front Endocrinol (Lausanne)202642729112PubTator, text miningPubMed
Long-Read Sequencing Resolves Complex CYP21A2 Variants and Identifies 2+0 Carriers in 21-Hydroxylase Deficiency.J Mol Diagn202642727689PubTator, text miningPubMed
Case Report: unmasking pseudo-homozygosity in CYP21A2: intergenerational gene conversion expansion and the necessity of multimodal genetic testing.Front Endocrinol (Lausanne)202642682406PubTator, text miningPubMed
Clinical and genetic spectrum of classic congenital adrenal hyperplasia due to CYP21A2 mutations in a Taiwanese cohort.Pediatr Neonatol202642680663PubTator, text miningPubMed
A Comprehensive Pipeline for the Use of Short Read Next-Generation Sequencing (SR-NGS) in CYP21A2 Diagnostic Genotyping.Curr Issues Mol Biol202642651824PubTator, text miningPubMed
Prepubertal Screening for Testicular Adrenal Rest Tumors in Boys with Classic Congenital Adrenal Hyperplasia: Emerging Evidence and Practical Implications.Children (Basel)202642650343PubTator, text miningPubMed

1 to 10 of 3,802

See all 3,802 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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