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Gene · 16

AARS1: alanyl-tRNA synthetase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AARS1: alanyl-tRNA synthetase 1. Genes, record 16. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/16

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Gene

Symbol
AARS1
HGNC
Name
alanyl-tRNA synthetase 1
HGNC
NCBI Gene ID
16
NCBI Gene
HGNC ID
HGNC:20
HGNC
Ensembl
ENSG00000090861
NCBI Gene
Aliases
AARS, AlaRS, CMT2N, DEE29, EIEE29, HDLS2, TTD8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49588Alanine--tRNA ligase, cytoplasmic9686Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436953P49588Espacenet
EP 4650780 A22025-11-191955P49588Espacenet
JP 2025517970 A2025-06-121955P49588Espacenet
JP 2025062604 A2025-04-143762P49588Espacenet
US 11446398 B22022-09-203762P49588Espacenet
JP 2022524081 A2022-04-27106733P49588Espacenet
US 11078247 B22021-08-0326P49588Espacenet
WO 2020043864 A12020-03-052516P49588Espacenet
JP 2019054813 A2019-04-11217388P49588Espacenet
EP 3362087 A12018-08-2231P49588Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,091

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAARS1 papersNewest fiscal year
R15GM113203Bioconjugations Employing Unnatural Amino Acids72025
P30CA008748Cancer Center Support Grant62025
R35GM136437A genetically encoded toolset to decipher the biology of post-translational modifications in the mammalian proteome62025
R01NS124547The mammalian multi-tRNA synthetase complex52025
R35GM139627Link extracellular function of tRNA synthetase with pathological mechanism of disease52025
ZIALM000073Comparative Analysis Of Completely Sequenced Genomes52025
P30CA034196Cancer Center Support (CORE) Grant42025
ZIAHG000215Human Biochemical Genetics42025
P30CA014195Cancer Center Support Grant (CCSG)32025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 1,091Source NIH's project files

See all 1,091 nih grants

Papers1,850

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Natural Asp-tRNA synthetase fragment targets myofibroblasts to abrogate tissue fibrosis.J Biol Chem202642815638PubTator, text miningPubMed
Aminoacyl-tRNA synthetases in tumor immunity: canonical translation, source-resolved immune circuits and therapeutic opportunities.Front Immunol202642769515PubTator, text miningPubMed
Advances in Research on AARS1/AARS2-Related Disorders: A Focus on Leukodystrophies.Genes (Basel)202642650065PubTator, text miningPubMed
Genetic code expansion for single noncanonical amino acid incorporation into SARS-CoV-2 Omicron spike on amber-free lentiviral particles.Methods Enzymol202642349953PubTator, text miningPubMed
Lactate as a Chemical Modification on Proteins and Metabolites.Annu Rev Biochem202642331744PubTator, text miningPubMed
The Evolution of the First Code.Genes (Basel)202642195003PubTator, text miningPubMed
Potent reaction hijacking inhibitors of Plasmodium falciparum asparagine tRNA synthetase.bioRxiv202642182159PubTator, text miningPubMed
Aminoacyl-tRNA Synthetases: Variant Classification, Functional Assays, and Emerging Therapeutic Strategies.J Inherit Metab Dis202642028791PubTator, text miningPubMed
Causal relationship between genetically predicted Enzyme and Tinnitus risk: a two-sample bi-directional mendelian randomization study.Braz J Otorhinolaryngol202641895103PubTator, text miningPubMed
Genetic Incorporation of Diverse Noncanonical Amino Acids for Histidine Substitution.J Am Chem Soc202641885601PubTator, text miningPubMed

1 to 10 of 1,850

See all 1,850 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/16

GET https://conductscience.org/api/genes/v1/16/patents?page=2