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DBH: dopamine beta-hydroxylase

1 protein, 49 patents, 1 drug, 2 trials, 3,513 NIH grants and 7,219 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolDBHHGNC
Namedopamine beta-hydroxylaseHGNC
NCBI Gene ID1621NCBI Gene
HGNC IDHGNC:2689HGNC
EnsemblENSG00000123454NCBI Gene
AliasesDBM, ORTHYP1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P09172Dopamine beta-hydroxylase6171Ensembl, GeneID, HGNCUniProt

Patents 49

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444190P09172Espacenet
EP 4640849 A22025-10-291680P09172Espacenet
EP 4641201 A22025-10-2911398P09172Espacenet
JP 2025147176 A2025-10-063967P09172Espacenet
JP 2025529142 A2025-09-046115P09172Espacenet
US 12371689 B22025-07-296115P09172Espacenet
JP 2025519096 A2025-06-241680P09172Espacenet
JP 2025517969 A2025-06-1211398P09172Espacenet
JP 2025032204 A2025-03-1127100P09172Espacenet
JP 2025028160 A2025-02-283967P09172Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ZAMICASTATCHEMBL4594440Dopamine beta-hydroxylase inhibitorINHIBITORChEMBL

Trials 2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06009185ZAMICASTATPHASE2ClinicalTrials.gov
NCT04316143ZAMICASTATPHASE22024-10-15ClinicalTrials.gov

NIH grants 3513

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01DK031450Mechanistic Intermediates in Copper Oxygenases and Oxidases152,025NIH's project files
ZIANS003034Biomarkers of Catecholaminergic Neurodegeneration132,025NIH's project files
P30CA008748Cancer Center Support Grant122,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)92,025NIH's project files
R01DK071865Molecular Mechanisms of Active Copper Transport72,025NIH's project files
K12DA000167Clinician Scientist Training Program (CSTP)62,025NIH's project files
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION62,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)52,025NIH's project files
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology52,025NIH's project files
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits52,025NIH's project files

Papers 7219

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42802063PubTator, text miningPubMed
42726637PubTator, text miningPubMed
42643105PubTator, text miningPubMed
42635618PubTator, text miningPubMed
42575453PubTator, text miningPubMed
42566406PubTator, text miningPubMed
42525434PubTator, text miningPubMed
42467707PubTator, text miningPubMed
42222674PubTator, text miningPubMed
42182502PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license