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ACE: angiotensin I converting enzyme

1 protein, 77 patents, 26 drugs, 271 trials, 8,748 NIH grants and 40,411 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolACEHGNC
Nameangiotensin I converting enzymeHGNC
NCBI Gene ID1636NCBI Gene
HGNC IDHGNC:2707HGNC
EnsemblENSG00000159640NCBI Gene
AliasesACE1, CD143, DCP, DCP1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P12821Angiotensin-converting enzyme1,30697Ensembl, GeneID, HGNCUniProt

Patents 77

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12653839 B22026-06-16156P12821Espacenet
JP 2026004568 A2026-01-1437386P12821Espacenet
EP 4667578 A22025-12-24100P12821Espacenet
EP 4667578 A22025-12-2499P12821Espacenet
EP 4650780 A22025-11-193446P12821Espacenet
EP 4640849 A22025-10-29432P12821Espacenet
EP 4641201 A22025-10-293029P12821Espacenet
EP 4641202 A22025-10-29176P12821Espacenet
EP 4641203 A22025-10-29114P12821Espacenet
JP 2025147176 A2025-10-06112P12821Espacenet

Drugs 26

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BENAZEPRILCHEMBL838Angiotensin-converting enzyme inhibitorINHIBITORChEMBL
BENAZEPRIL HYDROCHLORIDECHEMBL1694Angiotensin-converting enzyme inhibitorINHIBITORChEMBL
CAPTOPRILCHEMBL1560Angiotensin-converting enzyme inhibitorINHIBITORChEMBL
CILAZAPRILCHEMBL515606Angiotensin-converting enzyme inhibitorINHIBITORChEMBL
DELAPRILCHEMBL589583Angiotensin-converting enzyme inhibitorINHIBITORChEMBL
ENALAPRILCHEMBL578Angiotensin-converting enzyme inhibitorINHIBITORChEMBL
ENALAPRIL MALEATECHEMBL1200659Angiotensin-converting enzyme inhibitorINHIBITORChEMBL
ENALAPRILATCHEMBL3989406Angiotensin-converting enzyme inhibitorINHIBITORChEMBL
ENALAPRILAT ANHYDROUSCHEMBL577Angiotensin-converting enzyme inhibitorINHIBITORChEMBL
FOSINOPRILCHEMBL3039598Angiotensin-converting enzyme inhibitorINHIBITORChEMBL

Trials 271

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07363343ENALAPRILClinicalTrials.gov
NCT07272486CAPTOPRILClinicalTrials.gov
NCT07259733PERINDOPRILClinicalTrials.gov
NCT07222852ENALAPRILPHASE3ClinicalTrials.gov
NCT07099677RAMIPRILClinicalTrials.gov
NCT07023003ENALAPRILPHASE4ClinicalTrials.gov
NCT06788314ENALAPRILPHASE2ClinicalTrials.gov
NCT06745726LISINOPRILClinicalTrials.gov
NCT06275763PERINDOPRILPHASE4ClinicalTrials.gov
NCT06259175PERINDOPRILClinicalTrials.gov

NIH grants 8748

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
UL1TR001863Yale Clinical and Translational Science Award532,025NIH's project files
P30AG021332Wake Forest Claude D. Pepper OAIC - Renewal362,025NIH's project files
T32HL094301Noninvasive Cardiovascular Imaging Research Training Program262,025NIH's project files
T32HL130025Multidisciplinary Research Training to Reduce Inequalities in Cardiovascular Health252,025NIH's project files
P30CA008748Cancer Center Support Grant212,025NIH's project files
U01DK060902Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center212,025NIH's project files
P30CA016672Cancer Center Support Grant202,025NIH's project files
U01DK060963Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study202,025NIH's project files
U01DK060984Prospective renal insufficiency cohort evaluation: PRICE192,025NIH's project files
U01DK061022Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical Center192,025NIH's project files

Papers 40411

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42813201PubTator, text miningPubMed
42808983PubTator, text miningPubMed
42796473PubTator, text miningPubMed
42794105PubTator, text miningPubMed
42776811PubTator, text miningPubMed
42775903PubTator, text miningPubMed
42775047PubTator, text miningPubMed
42769660PubTator, text miningPubMed
42756361PubTator, text miningPubMed
42750874PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license