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Gene · 1638

DCT: dopachrome tautomerase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DCT: dopachrome tautomerase. Genes, record 1638. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1638

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Gene

Symbol
DCT
HGNC
Name
dopachrome tautomerase
HGNC
NCBI Gene ID
1638
NCBI Gene
HGNC ID
HGNC:2709
HGNC
Ensembl
ENSG00000080166
NCBI Gene
Aliases
OCA8, TRP-2, TRP2, TYRP2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P40126L-dopachrome tautomerase5191Ensembl, GeneID, HGNC

Source UniProt

Patents77

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199866P40126Espacenet
EP 4641201 A22025-10-2910115P40126Espacenet
JP 2025529142 A2025-09-041230P40126Espacenet
US 12371689 B22025-07-291230P40126Espacenet
JP 2025517969 A2025-06-1210115P40126Espacenet
JP 2025517970 A2025-06-129866P40126Espacenet
EP 4487869 A22025-01-08498P40126Espacenet
KR 1020240027895 A2024-03-04684P40126Espacenet
JP 2024508357 A2024-02-2711P40126Espacenet
KR 1020230138479 A2023-10-057P40126Espacenet

1 to 10 of 77

See all 77 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,390

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDCT papersNewest fiscal year
R01AR043369MITF from control of pigmentation to melanoma risk202025
P30CA008748Cancer Center Support Grant162025
P01CA163222Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment132025
P30CA016672Cancer Center Support Grant132025
P30CA076292Moffitt Cancer Center Support Grant92025
ZIAEY000476Proteins From Hereditary Eye Diseases: In silico and Experimental Studies92025
P30CA010815Consolidated Basic Cancer Research Program72025
P30CA086862Cancer Center Support Grant72025
R01AR072304Therapeutic strategies for treatment of giant congenital melanocytic nevi62025
I01BX004293CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer52025

1 to 10 of 1,390Source NIH's project files

See all 1,390 nih grants

Papers2,693

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Self-assembled micelles of Glycyrrhizic acid and Glabridin: A novel transdermal delivery system with enhanced whitening efficacy.Int J Pharm202642822710PubTator, text miningPubMed
HINT1 and ARMC10 modulate melanogenesis associated with oxidative stress and mitochondrial dysfunction in melanocytes.Biochim Biophys Acta Mol Cell Res202642810595PubTator, text miningPubMed
Immune-Cell Profiling Identifies a Defective Macrophage-Maresin 1 Resolution Axis as a Pathogenic Driver and Therapeutic Target in Vitiligo and Canities.J Cutan Med Surg202642741921PubTator, text miningPubMed
Extracellular vesicles derived from the lactic acid bacterium Enterococcus rotai suppress melanogenesis by modulating the cAMP-MITF pathway.Bioresour Bioprocess202642730979PubTator, text miningPubMed
CXCL1-CXCR2 axis inhibits melanogenesis through the suppression of the WNT/β-catenin pathway.Front Immunol202642601941PubTator, text miningPubMed
Smarcc1 drives optic stalk patterning and optic nerve head astrocyte differentiation.Development202642592906PubTator, text miningPubMed
Retinal Response to Low-Level Red-Light Therapy in Myopic and Non-Myopic Eyes Assessed Using Global Flash Multifocal Electroretinogram.Vision (Basel)202642496482PubTator, text miningPubMed
Evaluation of Melanocytes and T-cells in Vitiliginous Skin Pre- and Post-Narrow-Band UVB Phototherapy.Indian Dermatol Online J202642377206PubTator, text miningPubMed
An engineered probiotic co-expressing dual melanoma epitopes for therapeutic cancer vaccination.J Control Release202642331227PubTator, text miningPubMed
Hepatocyte growth factor suppresses melanogenesis via ERK-dependent nuclear exclusion of MITF.Cell Biosci202642323670PubTator, text miningPubMed

1 to 10 of 2,693

See all 2,693 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1638

GET https://conductscience.org/api/genes/v1/1638/patents?page=2