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Gene · 1639

DCTN1: dynactin subunit 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DCTN1: dynactin subunit 1. Genes, record 1639. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1639

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Gene

Symbol
DCTN1
HGNC
Name
dynactin subunit 1
HGNC
NCBI Gene ID
1639
NCBI Gene
HGNC ID
HGNC:2711
HGNC
Ensembl
ENSG00000204843
NCBI Gene
Aliases
DAP-150, DP-150, HMND14, P135
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14203Dynactin subunit 11,27813Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444379Q14203Espacenet
EP 4650780 A22025-11-197944Q14203Espacenet
EP 4641201 A22025-10-298032Q14203Espacenet
JP 2025517969 A2025-06-128032Q14203Espacenet
JP 2025517970 A2025-06-127944Q14203Espacenet
US 12258376 B22025-03-2525Q14203Espacenet
JP 2023123507 A2023-09-05132Q14203Espacenet
US 11446398 B22022-09-2025878Q14203Espacenet
JP 2022524081 A2022-04-27128849Q14203Espacenet
JP 2022502411 A2022-01-1112Q14203Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants900

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDCTN1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions62025
T32AG000255Training in age related neurodegenerative diseases62025
P30CA016672Cancer Center Support Grant52025
ZIAAG000933Genetic etiology of Amyotrophic Lateral Sclerosis52025
I01BX002466VA Biorepository Brain Bank32025
P30AG066514Mount Sinai Alzheimer's Disease Research Center32025
R01NS120926Creating a foundation for personalized age- and sex-based immune-targeted therapies from an ALS longitudinal cohort by identifying peripheral and central immune signatures32025
R37AR027883Cell adhesion and tissue dynamics in the skin32025
ZIANS003154Genetic characterization of atypical parkinsonism32025

1 to 10 of 900Source NIH's project files

See all 900 nih grants

Papers1,366

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
OGT-mediated O-GlcNAcylation of BICD2 drives gemcitabine resistance in pancreatic cancer via accelerating G2/M cell cycle progression.Drug Resist Updat202642600365PubTator, text miningPubMed
The causal role of plasma protein ratios in ulcerative colitis: insights from mendelian randomization and single-cell sequencing.Open Med (Wars)202642577736PubTator, text miningPubMed
Rescuing a refractory Leiomyosarcoma: ALK-DCTN1 fusion as a gateway to long-term control with Ceritinib.Gynecol Oncol Rep202642569171PubTator, text miningPubMed
Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications.Lancet Neurol202642456684PubTator, text miningPubMed
[Rare hereditary and acquired diseases with parkinson's syndrome].Fortschr Neurol Psychiatr202642392185PubTator, text miningPubMed
p.Ile87Val is a novel conservative DCTN1 variant causing Perry syndrome.Parkinsonism Relat Disord202641921430PubTator, text miningPubMed
Multifactorial anticholinergic toxicity-like presentation and malignant parkinsonism in Perry syndrome.Parkinsonism Relat Disord202641864034PubTator, text miningPubMed
Structural and functional brain asymmetry in relation to heterogeneous causes of situs inversus totalis.Brain Struct Funct202641824087PubTator, text miningPubMed
Short tandem repeat expansions in patients with neurodegenerative dementia.EBioMedicine202641762523PubTator, text miningPubMed
The Development of Novel Treatment Strategies for Rhabdomyosarcoma.Cancers (Basel)202641749943PubTator, text miningPubMed

1 to 10 of 1,366

See all 1,366 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1639

GET https://conductscience.org/api/genes/v1/1639/patents?page=2