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Gene · 1642

DDB1: damage specific DNA binding protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DDB1: damage specific DNA binding protein 1. Genes, record 1642. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1642

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Gene

Symbol
DDB1
HGNC
Name
damage specific DNA binding protein 1
HGNC
NCBI Gene ID
1642
NCBI Gene
HGNC ID
HGNC:2717
HGNC
Ensembl
ENSG00000167986
NCBI Gene
Aliases
DDBA, UV-DDB1, WHIKERS, XAP1, XPCE, XPE, XPE-BF
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16531DNA damage-binding protein 11,140213Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194100Q16531Espacenet
JP 2025517970 A2025-06-124100Q16531Espacenet
JP 2024123008 A2024-09-105848Q16531Espacenet
US 11504404 B22022-11-22174Q16531Espacenet
US 11459613 B22022-10-0422Q16531Espacenet
US 11446398 B22022-09-2022420Q16531Espacenet
US 11400116 B22022-08-022502Q16531Espacenet
JP 2022524081 A2022-04-27125391Q16531Espacenet
JP 2021169490 A2021-10-28260Q16531Espacenet
US 11078247 B22021-08-032937Q16531Espacenet

1 to 10 of 31

See all 31 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IBERDOMIDECHEMBL3989927CRL4(CRBN) E3 ubiquitin ligase modulatorMODULATORChEMBL
LENALIDOMIDECHEMBL848CRL4(CRBN) E3 ubiquitin ligase inhibitorINHIBITORChEMBL
LENALIDOMIDECHEMBL848CRL4(CRBN) E3 ubiquitin ligase modulatorMODULATORChEMBL
LENALIDOMIDE HYDROCHLORIDE MONOHYDRATECHEMBL6068337CRL4(CRBN) E3 ubiquitin ligase modulatorMODULATORChEMBL
POMALIDOMIDECHEMBL43452CRL4(CRBN) E3 ubiquitin ligase inhibitorINHIBITORChEMBL
THALIDOMIDECHEMBL468CRL4(CRBN) E3 ubiquitin ligase inhibitorINHIBITORChEMBL

Trials1,695

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416LENALIDOMIDEPHASE2ClinicalTrials.gov
NCT07601100IBERDOMIDEPHASE1/PHASE2ClinicalTrials.gov
NCT07600151LENALIDOMIDEPHASE1/PHASE2ClinicalTrials.gov
NCT07585747LENALIDOMIDEPHASE2ClinicalTrials.gov
NCT07569757POMALIDOMIDEPHASE3ClinicalTrials.gov
NCT07562022LENALIDOMIDEPHASE3ClinicalTrials.gov
NCT07555938POMALIDOMIDEPHASE3ClinicalTrials.gov
NCT07532525POMALIDOMIDEPHASE1ClinicalTrials.gov
NCT07523737POMALIDOMIDEPHASE2ClinicalTrials.gov
NCT07505849LENALIDOMIDEPHASE2ClinicalTrials.gov

1 to 10 of 1,695

See all 1,695 trials

NIH grants2,290

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDDB1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant222025
R01CA214608The molecular basis of IMiD induced neo-substrate recruitment to the CRL4CRBN ubiquitin E3 ligase172025
P01CA092584Structural Cell Biology of DNA Repair Machines142025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control142025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias132025
P30CA008748Cancer Center Support Grant132025
P30CA021765Cancer Center Support Grant (CCSG)132025
P30CA014599Cancer Center Support Grant112025
R01CA218278Degrading therapeutically important kinases using small molecules112025
P30CA016087Cancer Center Support Grant102025

1 to 10 of 2,290Source NIH's project files

See all 2,290 nih grants

Papers3,503

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structural basis of diverse substrate recruitment by the HIV-1 Vpr-hijacked CRL4(VprBP) E3 ligase.PLoS Pathog202642821551PubTator, text miningPubMed
Lipid Conjugation of a Photoprotective Meadowfoam (Limnanthes alba) Glucolimnanthin Derivative Reduces Cytotoxicity, Attenuates UV-Induced DNA Damage and Activates DNA Repair in Human Keratinocytes Following UV Radiation.
Biomolecules202642650817PubTator, text miningPubMed
Ubiquitin-dependent control of PD-L1 nuclear translocation by DDB1 dictates anti-PD-1 response.Sci Bull (Beijing)202642608270PubTator, text miningPubMed
HBx Downregulates TFEB via the CUL4A/CUL4B-DDB1 Axis to Disrupt Lysosomal Function in Hepatocellular Carcinoma Cells.Cells202642505369PubTator, text miningPubMed
CRISPR/Cas9 screen identifies DCAF4 as a novel protector of hepatocellular carcinoma against brachytherapy via stress granule-dependent NRF2 activation.Cell Death Dis202642449099PubTator, text miningPubMed
Synthesis of Nitazoxanide Derivatives as Potent and Orally Available HBx-DDB1 Inhibitors against Hepatitis B Virus.ACS Med Chem Lett202642445001PubTator, text miningPubMed
DCAF13 is associated with pancreatic ductal adenocarcinoma progression and p53-related signaling in TP53-mutant cells.Biochem Biophys Res Commun202642361739PubTator, text miningPubMed
UV-DDB as a Dynamic Regulator Linking Base Excision and Nucleotide Excision Repair via AAG Interaction.Int J Mol Sci202642353235PubTator, text miningPubMed
Beyond KEAP1: The Context-Specific NRF2 Partner Code in Disease and Therapy.Antioxidants (Basel)202642352065PubTator, text miningPubMed
Structural basis for selective and potent degradation of IRAK4 by KT-474.Nat Commun202642336816PubTator, text miningPubMed

1 to 10 of 3,503

See all 3,503 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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