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Gene · 1643

DDB2: damage specific DNA binding protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DDB2: damage specific DNA binding protein 2. Genes, record 1643. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1643

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Gene

Symbol
DDB2
HGNC
Name
damage specific DNA binding protein 2
HGNC
NCBI Gene ID
1643
NCBI Gene
HGNC ID
HGNC:2718
HGNC
Ensembl
ENSG00000134574
NCBI Gene
Aliases
DDBB, FLJ34321, UV-DDB2, XPE
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92466DNA damage-binding protein 242710Ensembl, GeneID, HGNC

Source UniProt

Patents66

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191612Q92466Espacenet
EP 4641202 A22025-10-294483Q92466Espacenet
JP 2025147176 A2025-10-0614867Q92466Espacenet
WO 2025125630 A12025-06-1918Q92466Espacenet
JP 2025517970 A2025-06-121612Q92466Espacenet
JP 2025028160 A2025-02-2814867Q92466Espacenet
KR 1020250017231 A2025-02-044483Q92466Espacenet
KR 1020250010750 A2025-01-2114867Q92466Espacenet
EP 4464338 A22024-11-202241Q92466Espacenet
JP 2024123008 A2024-09-105852Q92466Espacenet

1 to 10 of 66

See all 66 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,427

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDDB2 papersNewest fiscal year
P30CA014599Cancer Center Support Grant152025
P30ES010126UNC Center for Environmental Health and Susceptibility152025
P01CA092584Structural Cell Biology of DNA Repair Machines132025
R35ES031638Watching cooperative interactions between base and nucleotide excision repair proteins122025
P30CA008748Cancer Center Support Grant92025
P30CA016058Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant92025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control82025
P30CA047904Cancer Center Support Grant72025
R01GM117275Protein N-terminal Methylation Mechanisms and Inhibition72025

1 to 10 of 1,427Source NIH's project files

See all 1,427 nih grants

Papers2,095

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Point-of-Care Radiation Biodosimetry via a Body-Heated Reverse Transcription-Recombinase Polymerase Amplification Coupled to a Paper-Based Vertical Flow Immunoassay.Anal Chem202642689596PubTator, text miningPubMed
The conformation of the complementary strand and the deformation of the DNA groove upon DDB2 binding justifies the different repair rates for cyclobutane pyrimidine dimers.Photochem Photobiol Sci202642678658PubTator, text miningPubMed
Accurate estimation of clinically significant radiation doses up to 5 Gy using qRT-PCR based gene expression analysis.Int J Radiat Biol202642671271PubTator, text miningPubMed
Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistance.Proc Natl Acad Sci U S A202642607204PubTator, text miningPubMed
Divergent somatic mutation patterns among human cerebellar neuron types.Neuron202642575091PubTator, text miningPubMed
Correlation of a four gene set with H-ARS severity in irradiated minipigs treated with Myelo001.Int J Radiat Biol202642566227PubTator, text miningPubMed
Epigenetic remodeling during UV exposure: high resolution analysis of histone post-translational modifications in a DNA binding protein 2 mutant model.Histochem Cell Biol202642455165PubTator, text miningPubMed
UV-DDB as a Dynamic Regulator Linking Base Excision and Nucleotide Excision Repair via AAG Interaction.Int J Mol Sci202642353235PubTator, text miningPubMed
Characterization of Radiation-responsive Genes and Transcript Variants under Different Radiation Qualities, Doses and Dose Rates.Radiat Res202642307549PubTator, text miningPubMed
Salivary Gene Expression Changes after Total Body Irradiation in Leukemia Patients: Toward Non-invasive Biodosimetry.Radiat Res202642235939PubTator, text miningPubMed

1 to 10 of 2,095

See all 2,095 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1643

GET https://conductscience.org/api/genes/v1/1643/patents?page=2