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AKR1C2: aldo-keto reductase family 1 member C2
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Gene · 1646

Papers1,732

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 1,732

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TitleJournalYearPMIDFound bySource
Single-Cell Analysis of Cartilage-Derived Cells Identifies Diverse Populations and a Cholesterol/ER-Stress Chondrocyte Subset in Knee OA.J Orthop Res202642811796PubTator, text miningPubMed
Integrative single-cell and genomic analysis reveals NMB as a driver of metastatic adaptation in esophageal squamous cell carcinoma via metabolic rewiring and immune evasion.Front Cell Dev Biol202642740929PubTator, text miningPubMed
Development of clinical-radiological prediction models to prioritize ALK, ROS1, and RET fusion testing in major driver alteration-negative non-small cell lung cancer.J Thorac Dis202642724255PubTator, text miningPubMed
Integrating target prediction and transcriptomic analysis identifies the AKR1C2-KRT8 axis in rotenone-induced dopaminergic neuron injury.Brain Res Bull202642679909PubTator, text miningPubMed
In-silico study of active phytochemicals and molecular mechanism of Hydrocotyle javanica Thunb.in treating MDR enterobacterial infection.Bioresour Bioprocess202642622723PubTator, text miningPubMed
Harnessing tumor-associated exosomal aminopeptidase N as a dual-function tool for monitoring and tackling chemoresistance in gastric cancer.Cell Commun Signal202642458480PubTator, text miningPubMed
Single-nucleus analysis of menstrual fluid highlights gene expression differences in epithelial cells of endometriosis donors.BMC Med202642381032PubTator, text miningPubMed
Targeting Steroid-Metabolizing Enzymes with 15β-Substituted Estrone Analogues: Dual Discovery of AKR1C2/17β-HSD1 Inhibitors and a Fluorescent 17β-HSD1 Ligand.Cancers (Basel)202642352425PubTator, text miningPubMed
Rational design and structural insights of osthole-derived selective AKR1C3 inhibitors with cellular activity.Bioorg Chem202642335733PubTator, text miningPubMed
In silico analysis suggests ELL2 as a survival-associated cross-tissue biomarker in gastric cancer.Cancer Biomark202642333064PubTator, text miningPubMed
Human aldo-keto reductases (AKR1C1-AKR1C3) increase the mutagenicity of environmental nitroarenes in the mammalian HPRT forward gene mutagenicity assay.Mutat Res Genet Toxicol Environ Mutagen202642264600PubTator, text miningPubMed
Proteogenomic decoding of chemotherapy resistance in patients with triple-negative breast cancer.Genome Biol202641975515PubTator, text miningPubMed
Multimodal AI fuses proteomic and EHR data for rational prioritization of protein biomarkers in diabetic retinopathy.medRxiv202641918763PubTator, text miningPubMed
[Research Progress on Glycolytic Reprogramming and Lactylation Crosstalk in Tumors].Zhongguo Fei Ai Za Zhi202641916915PubTator, text miningPubMed
Isatin-Acenaphthoquinone Derived tetra-Schiff Base: Synthesis, Molecular Docking, Molecular Dynamics Simulation and Cytotoxic Potential in MCF-7 Breast Cancer Cells.Chem Biodivers202641893869PubTator, text miningPubMed
Post-Artemisinin anti-malarial discovery from nature: unaltered natural products, lead optimisation, and advanced techniques in the discovery.Nat Prod Res202641865385PubTator, text miningPubMed
A Five-Gene PANoptosis Signature Correlates with Immune Infiltration and Secondary Brain Injury in Intracerebral Hemorrhage.Int J Gen Med202641821641PubTator, text miningPubMed
Metabolic reprogramming in cancer: dysregulation of glucose, lipid, and amino acid pathways and therapeutic opportunities.Mol Biomed202641806079PubTator, text miningPubMed
Computational identification of Terminalia arjuna phytochemicals as potential 3α-HSD3 inhibitors.Sci Rep202641775750PubTator, text miningPubMed
Directed C-H activation of 13α-estrone: a pathway to promising AKR1C inhibitors via docking and biological studies.RSC Adv202641767230PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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