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Gene · 1646

AKR1C2: aldo-keto reductase family 1 member C2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AKR1C2: aldo-keto reductase family 1 member C2. Genes, record 1646. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1646

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Gene

Symbol
AKR1C2
HGNC
Name
aldo-keto reductase family 1 member C2
HGNC
NCBI Gene ID
1646
NCBI Gene
HGNC ID
HGNC:385
HGNC
Ensembl
ENSG00000151632
NCBI Gene
Aliases
AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P52895Aldo-keto reductase family 1 member C232316Ensembl, GeneID, HGNC

Source UniProt

Patents71

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437065P52895Espacenet
JP 2026004568 A2026-01-1437066P52895Espacenet
EP 4650780 A22025-11-1910367P52895Espacenet
JP 2025517970 A2025-06-1210367P52895Espacenet
JP 2025081326 A2025-05-2736P52895Espacenet
JP 2025062604 A2025-04-143968P52895Espacenet
JP 2025032204 A2025-03-1124358P52895Espacenet
JP 2025024198 A2025-02-199009P52895Espacenet
EP 4461818 A22024-11-1324358P52895Espacenet
US 11860162 B22024-01-021277P52895Espacenet

1 to 10 of 71

See all 71 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants907

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAKR1C2 papersNewest fiscal year
P30ES013508Center of Excellence in Environmental Toxicology752025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer102025
P50CA097186The Pacific Northwest Prostate Cancer SPORE92025
T32ES019851Translational Research Training Program in Environmental Health Sciences82025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease72025
P30CA016520Abramson Cancer Center Support Grant52025
P30DK019525University of Pennsylvania Diabetes Research Center52025
R01ES029294Metabolic activation of nitroarenes and Nrf2-Keap152025
T32DK007314Diabetes, Endocrine, and Metabolism52025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)42025

1 to 10 of 907Source NIH's project files

See all 907 nih grants

Papers1,732

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Single-Cell Analysis of Cartilage-Derived Cells Identifies Diverse Populations and a Cholesterol/ER-Stress Chondrocyte Subset in Knee OA.J Orthop Res202642811796PubTator, text miningPubMed
Integrative single-cell and genomic analysis reveals NMB as a driver of metastatic adaptation in esophageal squamous cell carcinoma via metabolic rewiring and immune evasion.Front Cell Dev Biol202642740929PubTator, text miningPubMed
Development of clinical-radiological prediction models to prioritize ALK, ROS1, and RET fusion testing in major driver alteration-negative non-small cell lung cancer.J Thorac Dis202642724255PubTator, text miningPubMed
Integrating target prediction and transcriptomic analysis identifies the AKR1C2-KRT8 axis in rotenone-induced dopaminergic neuron injury.Brain Res Bull202642679909PubTator, text miningPubMed
In-silico study of active phytochemicals and molecular mechanism of Hydrocotyle javanica Thunb.in treating MDR enterobacterial infection.Bioresour Bioprocess202642622723PubTator, text miningPubMed
Harnessing tumor-associated exosomal aminopeptidase N as a dual-function tool for monitoring and tackling chemoresistance in gastric cancer.Cell Commun Signal202642458480PubTator, text miningPubMed
Single-nucleus analysis of menstrual fluid highlights gene expression differences in epithelial cells of endometriosis donors.BMC Med202642381032PubTator, text miningPubMed
Targeting Steroid-Metabolizing Enzymes with 15β-Substituted Estrone Analogues: Dual Discovery of AKR1C2/17β-HSD1 Inhibitors and a Fluorescent 17β-HSD1 Ligand.Cancers (Basel)202642352425PubTator, text miningPubMed
Rational design and structural insights of osthole-derived selective AKR1C3 inhibitors with cellular activity.Bioorg Chem202642335733PubTator, text miningPubMed
In silico analysis suggests ELL2 as a survival-associated cross-tissue biomarker in gastric cancer.Cancer Biomark202642333064PubTator, text miningPubMed

1 to 10 of 1,732

See all 1,732 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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GET https://conductscience.org/api/genes/v1/1646/patents?page=2