Gene · 1646
AKR1C2: aldo-keto reductase family 1 member C2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. AKR1C2: aldo-keto reductase family 1 member C2. Genes, record 1646. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1646
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P52895 | Aldo-keto reductase family 1 member C2 | 323 | 16 | Ensembl, GeneID, HGNC |
Source UniProt
Patents71
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 37065 | P52895 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 37066 | P52895 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10367 | P52895 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10367 | P52895 | Espacenet |
| JP 2025081326 A | 2025-05-27 | 36 | P52895 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3968 | P52895 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 24358 | P52895 | Espacenet |
| JP 2025024198 A | 2025-02-19 | 9009 | P52895 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 24358 | P52895 | Espacenet |
| US 11860162 B2 | 2024-01-02 | 1277 | P52895 | Espacenet |
1 to 10 of 71
See all 71 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants907
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | AKR1C2 papers | Newest fiscal year |
|---|---|---|---|
| P30ES013508 | Center of Excellence in Environmental Toxicology | 75 | 2025 |
| P01CA163227 | Androgen Receptor Action in Castration Resistant Prostate Cancer | 10 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 9 | 2025 |
| T32ES019851 | Translational Research Training Program in Environmental Health Sciences | 8 | 2025 |
| P30DK052574 | Host-environment interactions in the pathophysiology of digestive disease | 7 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 5 | 2025 |
| P30DK019525 | University of Pennsylvania Diabetes Research Center | 5 | 2025 |
| R01ES029294 | Metabolic activation of nitroarenes and Nrf2-Keap1 | 5 | 2025 |
| T32DK007314 | Diabetes, Endocrine, and Metabolism | 5 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 4 | 2025 |
1 to 10 of 907Source NIH's project files
See all 907 nih grantsPapers1,732
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Single-Cell Analysis of Cartilage-Derived Cells Identifies Diverse Populations and a Cholesterol/ER-Stress Chondrocyte Subset in Knee OA. | J Orthop Res | 2026 | 42811796 | PubTator, text mining | PubMed |
| Integrative single-cell and genomic analysis reveals NMB as a driver of metastatic adaptation in esophageal squamous cell carcinoma via metabolic rewiring and immune evasion. | Front Cell Dev Biol | 2026 | 42740929 | PubTator, text mining | PubMed |
| Development of clinical-radiological prediction models to prioritize ALK, ROS1, and RET fusion testing in major driver alteration-negative non-small cell lung cancer. | J Thorac Dis | 2026 | 42724255 | PubTator, text mining | PubMed |
| Integrating target prediction and transcriptomic analysis identifies the AKR1C2-KRT8 axis in rotenone-induced dopaminergic neuron injury. | Brain Res Bull | 2026 | 42679909 | PubTator, text mining | PubMed |
| In-silico study of active phytochemicals and molecular mechanism of Hydrocotyle javanica Thunb.in treating MDR enterobacterial infection. | Bioresour Bioprocess | 2026 | 42622723 | PubTator, text mining | PubMed |
| Harnessing tumor-associated exosomal aminopeptidase N as a dual-function tool for monitoring and tackling chemoresistance in gastric cancer. | Cell Commun Signal | 2026 | 42458480 | PubTator, text mining | PubMed |
| Single-nucleus analysis of menstrual fluid highlights gene expression differences in epithelial cells of endometriosis donors. | BMC Med | 2026 | 42381032 | PubTator, text mining | PubMed |
| Targeting Steroid-Metabolizing Enzymes with 15β-Substituted Estrone Analogues: Dual Discovery of AKR1C2/17β-HSD1 Inhibitors and a Fluorescent 17β-HSD1 Ligand. | Cancers (Basel) | 2026 | 42352425 | PubTator, text mining | PubMed |
| Rational design and structural insights of osthole-derived selective AKR1C3 inhibitors with cellular activity. | Bioorg Chem | 2026 | 42335733 | PubTator, text mining | PubMed |
| In silico analysis suggests ELL2 as a survival-associated cross-tissue biomarker in gastric cancer. | Cancer Biomark | 2026 | 42333064 | PubTator, text mining | PubMed |
1 to 10 of 1,732
See all 1,732 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1646
GET https://conductscience.org/api/genes/v1/1646/patents?page=2