Gene · 1654
DDX3X: DEAD-box helicase 3 X-linked
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DDX3X: DEAD-box helicase 3 X-linked. Genes, record 1654. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1654
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O00571 | ATP-dependent RNA helicase DDX3X | 662 | 17 | Ensembl, GeneID, HGNC |
Source UniProt
Patents43
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4820394 A1 | 2026-10-14 | 234 | O00571 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 43140 | O00571 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 18331 | O00571 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 22775 | O00571 | Espacenet |
| EP 4623996 A2 | 2025-10-01 | 7 | O00571 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 22775 | O00571 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 18331 | O00571 | Espacenet |
| JP 2024045573 A | 2024-04-02 | 7 | O00571 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 22739 | O00571 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 22742 | O00571 | Espacenet |
1 to 10 of 43
See all 43 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,178
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DDX3X papers | Newest fiscal year |
|---|---|---|---|
| P30CA021765 | Cancer Center Support Grant (CCSG) | 16 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 14 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| R01CA159859 | Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma | 10 | 2025 |
| R01AI124346 | Innate immune signaling and stress response | 9 | 2025 |
| R37AI101935 | Inflammatory Caspases in Innate Immunity and Inflammation | 9 | 2025 |
| P01CA096832 | NORMAL & NEOPLASTIC GROWTH IN THE BRAIN | 8 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 8 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 8 | 2025 |
| R01NS120667 | Cellular and molecular mechanisms underlying DDX3X syndrome | 8 | 2025 |
1 to 10 of 2,178Source NIH's project files
See all 2,178 nih grantsPapers3,637
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| DDX3X regulates DNA repair pathway choice at double-strand breaks via RNA-DNA hybrid formation. | Cell Death Differ | 2026 | 42791328 | PubTator, text mining | PubMed |
| Spatially Constrained Monte Carlo Permutation Test Reveals Diffusion Changes Near Stress Granules. | bioRxiv | 2026 | 42779797 | PubTator, text mining | PubMed |
| Extracellular vesicles shape tumourigenesis: from signalling networks to systemic progression. | Cancer Metastasis Rev | 2026 | 42776258 | PubTator, text mining | PubMed |
| Stress granule phase transitions and neuronal fate in cerebral ischemia-reperfusion injury. | Front Mol Neurosci | 2026 | 42769600 | PubTator, text mining | PubMed |
| [A retrospective analysis of clinicopathological features and efficacy in 51 patients with high-grade B-cell lymphoma with 11q abnormalities]. | Zhonghua Xue Ye Xue Za Zhi | 2026 | 42706163 | PubTator, text mining | PubMed |
| Delaying Stress Granule Disassembly by PARG Inhibition Attenuates Renal Tubular Cell Pyroptosis in Acute Kidney Injury. | Int J Mol Sci | 2026 | 42653197 | PubTator, text mining | PubMed |
| DDX3X-mediated rRNA condensate clearance during germinal vesicle breakdown facilitates chromosome segregation in oocytes. | Biol Reprod | 2026 | 42633584 | PubTator, text mining | PubMed |
| Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases. | Cell Mol Immunol | 2026 | 42618693 | PubTator, text mining | PubMed |
| DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated-Acute Kidney Injury. | Adv Sci (Weinh) | 2026 | 42606030 | PubTator, text mining | PubMed |
| DDX3X syndrome mutations lock DDX3X-RNA conformational states to drive persistent pathological condensation and neuronal death. | Hum Mol Genet | 2026 | 42497113 | PubTator, text mining | PubMed |
1 to 10 of 3,637
See all 3,637 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1654
GET https://conductscience.org/api/genes/v1/1654/patents?page=2