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Gene · 1654

DDX3X: DEAD-box helicase 3 X-linked

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DDX3X: DEAD-box helicase 3 X-linked. Genes, record 1654. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1654

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Gene

Symbol
DDX3X
HGNC
Name
DEAD-box helicase 3 X-linked
HGNC
NCBI Gene ID
1654
NCBI Gene
HGNC ID
HGNC:2745
HGNC
Ensembl
ENSG00000215301
NCBI Gene
Aliases
CAP-Rf, DBX, DDX14, DDX3, HLP2, MRX102, MRXSSB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00571ATP-dependent RNA helicase DDX3X66217Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4820394 A12026-10-14234O00571Espacenet
JP 2026004568 A2026-01-1443140O00571Espacenet
EP 4650780 A22025-11-1918331O00571Espacenet
EP 4641201 A22025-10-2922775O00571Espacenet
EP 4623996 A22025-10-017O00571Espacenet
JP 2025517969 A2025-06-1222775O00571Espacenet
JP 2025517970 A2025-06-1218331O00571Espacenet
JP 2024045573 A2024-04-027O00571Espacenet
US 11446398 B22022-09-2022739O00571Espacenet
US 11446398 B22022-09-2022742O00571Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,178

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDDX3X papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)162025
P30CA016672Cancer Center Support Grant142025
P30CA008748Cancer Center Support Grant122025
R01CA159859Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma102025
R01AI124346Innate immune signaling and stress response92025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation92025
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN82025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant82025
P30CA033572Cancer Center Support Grant82025
R01NS120667Cellular and molecular mechanisms underlying DDX3X syndrome82025

1 to 10 of 2,178Source NIH's project files

See all 2,178 nih grants

Papers3,637

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DDX3X regulates DNA repair pathway choice at double-strand breaks via RNA-DNA hybrid formation.Cell Death Differ202642791328PubTator, text miningPubMed
Spatially Constrained Monte Carlo Permutation Test Reveals Diffusion Changes Near Stress Granules.bioRxiv202642779797PubTator, text miningPubMed
Extracellular vesicles shape tumourigenesis: from signalling networks to systemic progression.Cancer Metastasis Rev202642776258PubTator, text miningPubMed
Stress granule phase transitions and neuronal fate in cerebral ischemia-reperfusion injury.Front Mol Neurosci202642769600PubTator, text miningPubMed
[A retrospective analysis of clinicopathological features and efficacy in 51 patients with high-grade B-cell lymphoma with 11q abnormalities].Zhonghua Xue Ye Xue Za Zhi202642706163PubTator, text miningPubMed
Delaying Stress Granule Disassembly by PARG Inhibition Attenuates Renal Tubular Cell Pyroptosis in Acute Kidney Injury.Int J Mol Sci202642653197PubTator, text miningPubMed
DDX3X-mediated rRNA condensate clearance during germinal vesicle breakdown facilitates chromosome segregation in oocytes.Biol Reprod202642633584PubTator, text miningPubMed
Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases.Cell Mol Immunol202642618693PubTator, text miningPubMed
DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated-Acute Kidney Injury.Adv Sci (Weinh)202642606030PubTator, text miningPubMed
DDX3X syndrome mutations lock DDX3X-RNA conformational states to drive persistent pathological condensation and neuronal death.Hum Mol Genet202642497113PubTator, text miningPubMed

1 to 10 of 3,637

See all 3,637 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1654

GET https://conductscience.org/api/genes/v1/1654/patents?page=2