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Gene · 1655

DDX5: DEAD-box helicase 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DDX5: DEAD-box helicase 5. Genes, record 1655. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1655

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Gene

Symbol
DDX5
HGNC
Name
DEAD-box helicase 5
HGNC
NCBI Gene ID
1655
NCBI Gene
HGNC ID
HGNC:2746
HGNC
Ensembl
ENSG00000108654
NCBI Gene
Aliases
G17P1, HLR1, HUMP68, p68
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17844Probable ATP-dependent RNA helicase DDX56142Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4692367 A12026-02-111P17844Espacenet
JP 2026004568 A2026-01-1443325P17844Espacenet
KR 1020250169534 A2025-12-031P17844Espacenet
EP 4650780 A22025-11-19644P17844Espacenet
EP 4641201 A22025-10-29448P17844Espacenet
JP 2025517969 A2025-06-12448P17844Espacenet
JP 2025517970 A2025-06-12644P17844Espacenet
WO 2024201691 A2024-10-031P17844Espacenet
WO 2024204648 A2024-10-031P17844Espacenet
JP 2023123507 A2023-09-055P17844Espacenet

1 to 10 of 73

See all 73 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,569

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDDX5 papersNewest fiscal year
P30CA023168Cancer Center Support Grant172025
P30CA016672Cancer Center Support Grant142025
P30CA008748Cancer Center Support Grant122025
R01GM097332The Role of DEAD-box Proteins in Gene Expression112025
P30CA016086Cancer Center Support Grant42025
P01CA013106Targeting Transcription and Splicing in Cancer32025
P30CA014051Cancer Center Support (Core) Grant32025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA033572Cancer Center Support Grant32025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant32025

1 to 10 of 1,569Source NIH's project files

See all 1,569 nih grants

Papers2,414

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Statement of Retraction: Knockdown of KRAB domain-associated protein 1 suppresses the proliferation, migration and invasion of thyroid cancer cells by regulating P68/DEAD box protein 5.Bioengineered202642822015PubTator, text miningPubMed
SRSF1 Maintains Sertoli Cell Proliferation and Survival by Regulating Alternative Splicing in Coordination With DDX5 and RBMX/RBMXL1.FASEB J202642764753PubTator, text miningPubMed
Cancer-associated fibroblast-enriched TAGLN orchestrates HGF/c-MET-dependent transcriptional reprogramming in gastric cancer.Cancer Lett202642710828PubTator, text miningPubMed
Unveiling the Immune Mechanisms of Hypertension With Single-Cell Transcriptome-Wide Mendelian Randomization.FASEB J202642622622PubTator, text miningPubMed
Author Correction: IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation.Nat Immunol202642608477PubTator, text miningPubMed
MTUS2-AS1 suppression promotes DDX5 protein degradation to enhance the sensitivity of PARP inhibitors in BRCA-wild triple negative breast cancer.Int J Biol Sci202642524562PubTator, text miningPubMed
A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns.Cell Rep202642475178PubTator, text miningPubMed
Soluplus®-based solid dispersion enhances oral bioavailability of A10: a cGAS-STING and ICD activator for bladder cancer therapy.Int J Pharm202642437626PubTator, text miningPubMed
A novel lncRNA HUDRPC suppresses ferroptosis via the DDX5/DDIT3 pathway to promote docetaxel resistance in prostate cancer.Cancer Lett202642435930PubTator, text miningPubMed
CLU delays fracture healing and intercepts osteogenic differentiation by enhancing SMURF1-mediated DDX5 ubiquitination.Biochem Pharmacol202642320699PubTator, text miningPubMed

1 to 10 of 2,414

See all 2,414 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1655

GET https://conductscience.org/api/genes/v1/1655/patents?page=2