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Gene · 1656

DDX6: DEAD-box helicase 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DDX6: DEAD-box helicase 6. Genes, record 1656. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1656

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Gene

Symbol
DDX6
HGNC
Name
DEAD-box helicase 6
HGNC
NCBI Gene ID
1656
NCBI Gene
HGNC ID
HGNC:2747
HGNC
Ensembl
ENSG00000110367
NCBI Gene
Aliases
HLR2, IDDILF, P54, RCK, Rck/p54
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P26196Probable ATP-dependent RNA helicase DDX64839Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026513742 A2026-05-019P26196Espacenet
JP 2026004568 A2026-01-1443330P26196Espacenet
JP 2026004568 A2026-01-1443331P26196Espacenet
JP 2026004568 A2026-01-1443332P26196Espacenet
EP 4650780 A22025-11-1915623P26196Espacenet
EP 4641201 A22025-10-2918740P26196Espacenet
WO 2025217591 A12025-10-1631P26196Espacenet
JP 2025517969 A2025-06-1218740P26196Espacenet
JP 2025517970 A2025-06-1215623P26196Espacenet
JP 2025024198 A2025-02-1911640P26196Espacenet

1 to 10 of 42

See all 42 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,116

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDDX6 papersNewest fiscal year
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P30CA008748Cancer Center Support Grant42025
P30CA015704Cancer Center Support Grant32025
P30CA016086Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30DK056338Texas Medical Center Digestive Diseases Center32025
P40OD010440Caenorhabditis Genetics Center32025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant22025
P30CA016056Roswell Park Cancer Center Support Grant22025
P30CA016058Cancer Center Support Grant22025

1 to 10 of 1,116Source NIH's project files

See all 1,116 nih grants

Papers1,303

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Interplay Between Autophagy and Porcine Epidemic Diarrhea Virus: From Molecular Mechanisms to Therapeutic Perspectives.Microorganisms202642795472PubTator, text miningPubMed
ERa-induced m6A reader HNRNPC maintains DDX6 mRNA stability to promote tumor progression in ER+BC.Br J Cancer202642786277PubTator, text miningPubMed
Deadenylation and decapping factors cooperatively stimulate biochemical activities of DEAD-box ATPase Dhh1.Nucleic Acids Res202642755361PubTator, text miningPubMed
The CCHCR1-UBAP2L Interaction Promotes UBAP2L Release from P-Bodies for Stress Granule Assembly.Int J Mol Sci202642653452PubTator, text miningPubMed
Evolutionary study of oncogenes and tumor suppressor genes in breast carcinoma.J Taibah Univ Med Sci202642633313PubTator, text miningPubMed
Phosphoproteomics identifies the DYRK1B protein kinase as a regulator of processing bodies.J Cell Sci202642592723PubTator, text miningPubMed
Live-attenuated Toxoplasma gondii RHΔddx6 mutant establishes comprehensive immunity against acute, chronic, and congenital toxoplasmosis.Virulence202642565651PubTator, text miningPubMed
Genome-Wide Association Studies and Deep-Learning Functional Annotation of Opioid Use Disorder across Three Ancestries in the All of Us Research Program.medRxiv202642528495PubTator, text miningPubMed
Deadenylation and Decapping Factors Cooperatively Stimulate Biochemical Activities of DEAD-Box ATPase Dhh1.bioRxiv202642388790PubTator, text miningPubMed
RNA helicase DDX6 governs ASC speck formation in P-bodies and the transition to stress granules via phase separation during inflammasome activation.Cell Discov202642342646PubTator, text miningPubMed

1 to 10 of 1,303

See all 1,303 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1656

GET https://conductscience.org/api/genes/v1/1656/patents?page=2