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Gene · 165918

RNF168: ring finger protein 168

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RNF168: ring finger protein 168. Genes, record 165918. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/165918

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Gene

Symbol
RNF168
HGNC
Name
ring finger protein 168
HGNC
NCBI Gene ID
165918
NCBI Gene
HGNC ID
HGNC:26661
HGNC
Ensembl
ENSG00000163961
NCBI Gene
Aliases
FLJ35794, RIDL, hRNF168
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8IYW5E3 ubiquitin-protein ligase RNF16857139Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462262Q8IYW5Espacenet
JP 2026004568 A2026-01-1462263Q8IYW5Espacenet
EP 4650780 A22025-11-195342Q8IYW5Espacenet
JP 2025517970 A2025-06-125342Q8IYW5Espacenet
US 11446398 B22022-09-2074870Q8IYW5Espacenet
JP 2022524081 A2022-04-27177841Q8IYW5Espacenet
US 11078247 B22021-08-039677Q8IYW5Espacenet
JP 2019054813 A2019-04-11242697Q8IYW5Espacenet
JP 2019054813 A2019-04-11242698Q8IYW5Espacenet
JP 2017121241 A2017-07-13242697Q8IYW5Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants990

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRNF168 papersNewest fiscal year
P30CA016672Cancer Center Support Grant122025
R01CA132878Post-translational Modifications in DNA Damage Response: a Structural Perspective92025
R01CA198279Shaping DNA Damage Response Networks Via Histone H2A Variants82025
P30CA008748Cancer Center Support Grant72025
P30CA016086Cancer Center Support Grant72025
P01CA092584Structural Cell Biology of DNA Repair Machines62025
R01CA174904Roles of Chromatin Modification in BRCA1 Dependent DNA Repair62025
ZIABC010959Relationship between DNA damage detection and signaling62025
P30CA014195Cancer Center Support Grant (CCSG)52025
P50CA116201Mayo Clinic Breast Cancer SPORE52025

1 to 10 of 990Source NIH's project files

See all 990 nih grants

Papers1,456

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Riddle syndrome with RNF168 mutation in first Asian family cluster exhibiting pulmonary fibrosis and achalasia.J Hum Genet202642806109PubTator, text miningPubMed
Ubiquitination in DNA double-strand break repair: Mechanisms, regulation, and therapeutic implications.Biochim Biophys Acta Rev Cancer202642800652PubTator, text miningPubMed
Interstitial Lung Disease in Children: Rare Genetic Variants Beyond Surfactant Dysfunction.Pediatr Pulmonol202642598967PubTator, text miningPubMed
RNF126 in Physiology and Disease: A Multifunctional RING-Type E3 Ubiquitin Ligase in Protein Homeostasis, DNA Repair, and Cancer.Cells202642439634PubTator, text miningPubMed
53BP1 orchestrates sequence feature of RAG targets to balance DNA repair outcomes during V(D)J recombination.Sci Adv202642172328PubTator, text miningPubMed
Stress granules promote DNA damage repair through the G3BP1/NAT10/ATF3 axis to facilitate nasopharyngeal carcinoma progression.Oncogene202642032366PubTator, text miningPubMed
Ubiquitin-dependent recruitment of SLFN11 to chromatin is regulated by deubiquitinase (DUB) and RNF168.Res Sq202641994138PubTator, text miningPubMed
Ubiquitin-dependent recruitment of SLFN11 to chromatin is regulated by deubiquitinase (DUB) and RNF168.bioRxiv202641929013PubTator, text miningPubMed
Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities.J Biomed Sci202641928257PubTator, text miningPubMed
An Update on Inborn Errors of V(D)J Recombination.Physiology (Bethesda)202641902554PubTator, text miningPubMed

1 to 10 of 1,456

See all 1,456 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/165918

GET https://conductscience.org/api/genes/v1/165918/patents