Gene · 165918
RNF168: ring finger protein 168
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RNF168: ring finger protein 168. Genes, record 165918. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/165918
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8IYW5 | E3 ubiquitin-protein ligase RNF168 | 571 | 39 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 62262 | Q8IYW5 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 62263 | Q8IYW5 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5342 | Q8IYW5 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5342 | Q8IYW5 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 74870 | Q8IYW5 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 177841 | Q8IYW5 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 9677 | Q8IYW5 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 242697 | Q8IYW5 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 242698 | Q8IYW5 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 242697 | Q8IYW5 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants990
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RNF168 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 12 | 2025 |
| R01CA132878 | Post-translational Modifications in DNA Damage Response: a Structural Perspective | 9 | 2025 |
| R01CA198279 | Shaping DNA Damage Response Networks Via Histone H2A Variants | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 7 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 6 | 2025 |
| R01CA174904 | Roles of Chromatin Modification in BRCA1 Dependent DNA Repair | 6 | 2025 |
| ZIABC010959 | Relationship between DNA damage detection and signaling | 6 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
| P50CA116201 | Mayo Clinic Breast Cancer SPORE | 5 | 2025 |
1 to 10 of 990Source NIH's project files
See all 990 nih grantsPapers1,456
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Riddle syndrome with RNF168 mutation in first Asian family cluster exhibiting pulmonary fibrosis and achalasia. | J Hum Genet | 2026 | 42806109 | PubTator, text mining | PubMed |
| Ubiquitination in DNA double-strand break repair: Mechanisms, regulation, and therapeutic implications. | Biochim Biophys Acta Rev Cancer | 2026 | 42800652 | PubTator, text mining | PubMed |
| Interstitial Lung Disease in Children: Rare Genetic Variants Beyond Surfactant Dysfunction. | Pediatr Pulmonol | 2026 | 42598967 | PubTator, text mining | PubMed |
| RNF126 in Physiology and Disease: A Multifunctional RING-Type E3 Ubiquitin Ligase in Protein Homeostasis, DNA Repair, and Cancer. | Cells | 2026 | 42439634 | PubTator, text mining | PubMed |
| 53BP1 orchestrates sequence feature of RAG targets to balance DNA repair outcomes during V(D)J recombination. | Sci Adv | 2026 | 42172328 | PubTator, text mining | PubMed |
| Stress granules promote DNA damage repair through the G3BP1/NAT10/ATF3 axis to facilitate nasopharyngeal carcinoma progression. | Oncogene | 2026 | 42032366 | PubTator, text mining | PubMed |
| Ubiquitin-dependent recruitment of SLFN11 to chromatin is regulated by deubiquitinase (DUB) and RNF168. | Res Sq | 2026 | 41994138 | PubTator, text mining | PubMed |
| Ubiquitin-dependent recruitment of SLFN11 to chromatin is regulated by deubiquitinase (DUB) and RNF168. | bioRxiv | 2026 | 41929013 | PubTator, text mining | PubMed |
| Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities. | J Biomed Sci | 2026 | 41928257 | PubTator, text mining | PubMed |
| An Update on Inborn Errors of V(D)J Recombination. | Physiology (Bethesda) | 2026 | 41902554 | PubTator, text mining | PubMed |
1 to 10 of 1,456
See all 1,456 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/165918
GET https://conductscience.org/api/genes/v1/165918/patents