Gene · 1666
DECR1: 2,4-dienoyl-CoA reductase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DECR1: 2,4-dienoyl-CoA reductase 1. Genes, record 1666. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1666
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16698 | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial | 335 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents23
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 35682 | Q16698 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 481 | Q16698 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 481 | Q16698 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 89 | Q16698 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 89 | Q16698 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 103060 | Q16698 | Espacenet |
| JP 2022519460 A | 2022-03-24 | 39 | Q16698 | Espacenet |
| KR 1020210131352 A | 2021-11-02 | 39 | Q16698 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 2987 | Q16698 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 666 | Q16698 | Espacenet |
1 to 10 of 23
See all 23 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,432
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DECR1 papers | Newest fiscal year |
|---|---|---|---|
| P30ES013508 | Center of Excellence in Environmental Toxicology | 17 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30ES005022 | Rutgers Center for Environmental Exposure and Disease (CEED) | 6 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 5 | 2025 |
| P30CA072720 | Cancer Center Support Grant | 5 | 2025 |
| R01CA163591 | Tumor cell metabolism in action | 5 | 2025 |
| R01ES004738 | Activated Macrophages and Ozone Toxicity | 5 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 4 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 4 | 2025 |
1 to 10 of 2,432Source NIH's project files
See all 2,432 nih grantsPapers3,981
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Ferroptosis at the Metabolic-Immune Interface in Metastatic Castration-Resistant Prostate Cancer: Mechanistic Evidence, Translational Gaps, and Combination Strategies. | Ann Surg Oncol | 2026 | 42778841 | PubTator, text mining | PubMed |
| High-Throughput Characterization of Human Fibroblast Responses to a Panel of Staphylococcus aureus Antigen Proteins Using Olink Proteomics. | Open Forum Infect Dis | 2026 | 42751267 | PubTator, text mining | PubMed |
| The role of ferroptosis in juvenile idiopathic arthritis: Causal inference and mediation by immune phenotypes. | Medicine (Baltimore) | 2026 | 42700015 | PubTator, text mining | PubMed |
| Monitoring Early Efficacy of the Checkpoint Immunotherapy Based on Fluorescence Lifetime Imaging Microscopy of the Patient-Derived Lymphocyte Subsets. | Biochemistry (Mosc) | 2026 | 42633724 | PubTator, text mining | PubMed |
| Critical amino acid residues in the N-terminal domain of NADPH-dependent assimilatory sulfite reductase flavoprotein mediate octameric assembly. | Protein Sci | 2026 | 42435307 | PubTator, text mining | PubMed |
| Disulfidptosis and its molecular mechanisms in cancer: mechanisms, regulation, and therapeutic potential. | Med Oncol | 2026 | 42397604 | PubTator, text mining | PubMed |
| Distinct causal associations of mitochondrial function-related proteins with eclampsia versus pre-eclampsia: a two-sample Mendelian randomization analysis. | J Matern Fetal Neonatal Med | 2026 | 42289879 | PubTator, text mining | PubMed |
| HSF1 modulates lipid metabolism and ferroptosis in sarcopenia: a novel diagnostic biomarker and therapeutic target. | Front Mol Biosci | 2026 | 42148151 | PubTator, text mining | PubMed |
| Targeting DECR1 Mitigates Ferroptosis in Airway Epithelial Cells and Promotes Inflammation Resolution in Asthma. | FASEB J | 2026 | 42139047 | PubTator, text mining | PubMed |
| DECR1 degradation by ursolic acid alleviates vascular calcification through inhibition of NF-κB/NLRP3 signaling pathway. | Free Radic Biol Med | 2026 | 42034130 | PubTator, text mining | PubMed |
1 to 10 of 3,981
See all 3,981 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1666
GET https://conductscience.org/api/genes/v1/1666/patents?page=2