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Gene · 1666

DECR1: 2,4-dienoyl-CoA reductase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DECR1: 2,4-dienoyl-CoA reductase 1. Genes, record 1666. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1666

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Gene

Symbol
DECR1
HGNC
Name
2,4-dienoyl-CoA reductase 1
HGNC
NCBI Gene ID
1666
NCBI Gene
HGNC ID
HGNC:2753
HGNC
Ensembl
ENSG00000104325
NCBI Gene
Aliases
DECR, NADPH, SDR18C1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q166982,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial3353Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435682Q16698Espacenet
EP 4650780 A22025-11-19481Q16698Espacenet
JP 2025517970 A2025-06-12481Q16698Espacenet
JP 2025062604 A2025-04-1489Q16698Espacenet
US 11446398 B22022-09-2089Q16698Espacenet
JP 2022524081 A2022-04-27103060Q16698Espacenet
JP 2022519460 A2022-03-2439Q16698Espacenet
KR 1020210131352 A2021-11-0239Q16698Espacenet
US 11078247 B22021-08-032987Q16698Espacenet
WO 2020043864 A12020-03-05666Q16698Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,432

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDECR1 papersNewest fiscal year
P30ES013508Center of Excellence in Environmental Toxicology172025
P30CA008748Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant82025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)62025
P30CA016520Abramson Cancer Center Support Grant52025
P30CA072720Cancer Center Support Grant52025
R01CA163591Tumor cell metabolism in action52025
R01ES004738Activated Macrophages and Ozone Toxicity52025
P30CA006973Regional Oncology Research Center42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025

1 to 10 of 2,432Source NIH's project files

See all 2,432 nih grants

Papers3,981

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Ferroptosis at the Metabolic-Immune Interface in Metastatic Castration-Resistant Prostate Cancer: Mechanistic Evidence, Translational Gaps, and Combination Strategies.Ann Surg Oncol202642778841PubTator, text miningPubMed
High-Throughput Characterization of Human Fibroblast Responses to a Panel of Staphylococcus aureus Antigen Proteins Using Olink Proteomics.Open Forum Infect Dis202642751267PubTator, text miningPubMed
The role of ferroptosis in juvenile idiopathic arthritis: Causal inference and mediation by immune phenotypes.Medicine (Baltimore)202642700015PubTator, text miningPubMed
Monitoring Early Efficacy of the Checkpoint Immunotherapy Based on Fluorescence Lifetime Imaging Microscopy of the Patient-Derived Lymphocyte Subsets.Biochemistry (Mosc)202642633724PubTator, text miningPubMed
Critical amino acid residues in the N-terminal domain of NADPH-dependent assimilatory sulfite reductase flavoprotein mediate octameric assembly.Protein Sci202642435307PubTator, text miningPubMed
Disulfidptosis and its molecular mechanisms in cancer: mechanisms, regulation, and therapeutic potential.Med Oncol202642397604PubTator, text miningPubMed
Distinct causal associations of mitochondrial function-related proteins with eclampsia versus pre-eclampsia: a two-sample Mendelian randomization analysis.J Matern Fetal Neonatal Med202642289879PubTator, text miningPubMed
HSF1 modulates lipid metabolism and ferroptosis in sarcopenia: a novel diagnostic biomarker and therapeutic target.Front Mol Biosci202642148151PubTator, text miningPubMed
Targeting DECR1 Mitigates Ferroptosis in Airway Epithelial Cells and Promotes Inflammation Resolution in Asthma.FASEB J202642139047PubTator, text miningPubMed
DECR1 degradation by ursolic acid alleviates vascular calcification through inhibition of NF-κB/NLRP3 signaling pathway.Free Radic Biol Med202642034130PubTator, text miningPubMed

1 to 10 of 3,981

See all 3,981 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1666

GET https://conductscience.org/api/genes/v1/1666/patents?page=2