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Gene · 1667

DEFA1: defensin alpha 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DEFA1: defensin alpha 1. Genes, record 1667. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1667

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Gene

Symbol
DEFA1
HGNC
Name
defensin alpha 1
HGNC
NCBI Gene ID
1667
NCBI Gene
HGNC ID
HGNC:2761
HGNC
Ensembl
ENSG00000206047
NCBI Gene
Aliases
DEF1, DEFA2, HNP-1, HP-1, HP1, MRS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P59665Neutrophil defensin 19419Ensembl, GeneID, HGNC

Source UniProt

Patents197

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443472P59665Espacenet
JP 2026004568 A2026-01-1443473P59665Espacenet
EP 4650780 A22025-11-1910573P59665Espacenet
EP 4650780 A22025-11-1910576P59665Espacenet
JP 2025147176 A2025-10-064120P59665Espacenet
JP 2025147176 A2025-10-064121P59665Espacenet
JP 2025147176 A2025-10-064122P59665Espacenet
JP 2025138725 A2025-09-252593P59665Espacenet
JP 2025138725 A2025-09-253297P59665Espacenet
JP 2025529142 A2025-09-046129P59665Espacenet

1 to 10 of 197

See all 197 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,231

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDEFA1 papersNewest fiscal year
P30CA016086Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)42025
R01GM072805Epigenetic inheritance of heterochromatin42025
P30CA008748Cancer Center Support Grant32025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA068485Cancer Center Support Grant32025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital32025
P30ES001247Environmental Agents as Modulators of Disease Processes32025
UL1TR001863Yale Clinical and Translational Science Award32025

1 to 10 of 1,231Source NIH's project files

See all 1,231 nih grants

Papers1,506

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Air Pollution-Associated Intracellular Metals, Immune Gene Expression, and Erythrocyte Indices in COPD with Anemia.Int J Chron Obstruct Pulmon Dis202642699267PubTator, text miningPubMed
Comparison of two classification systems for tissue eosinophilia in patients with chronic rhinosinusitis with nasal polyps.Eur Arch Otorhinolaryngol202642543427PubTator, text miningPubMed
Synovial fluid proteomic biomarkers in periprosthetic joint infection: A systematic review with gene ontology and protein network analyses.J Exp Orthop202642519810PubTator, text miningPubMed
Plasma proteomic and metabolomic profiling reveals molecular features relevant to neoadjuvant therapy response in locally advanced esophageal squamous cell carcinoma.Mol Cancer202642458504PubTator, text miningPubMed
Epigenetic control of telomeric RNA maintains heterochromatin in telomerase-driven cancers.Signal Transduct Target Ther202642236690PubTator, text miningPubMed
[Clinical Significance of CCRL2 Regulating Platelet Function in Pediatric Chronic Immune Thrombocytopenia].Zhongguo Shi Yan Xue Ye Xue Za Zhi202642227449PubTator, text miningPubMed
Transcriptomic Traces of Noise Exposure in Hearing Loss and Systematic Identification of Biomarker Candidates at the Molecular Scale.Int J Mol Sci202642196165PubTator, text miningPubMed
Modulation of ESKAPE Bacteria Properties by NK-92 and NK-92-Derived LEVs: First Insights.Int J Mol Sci202642123536PubTator, text miningPubMed
Neutrophil-related gene expression profile is associated with future paediatric bronchiectasis exacerbations.J Mol Med (Berl)202641917171PubTator, text miningPubMed
Exploring the shared genetic architecture between periodontitis and cardiovascular disease.BDJ Open202641916952PubTator, text miningPubMed

1 to 10 of 1,506

See all 1,506 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1667

GET https://conductscience.org/api/genes/v1/1667/patents?page=2