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Gene · 1672

DEFB1: defensin beta 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DEFB1: defensin beta 1. Genes, record 1672. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1672

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Gene

Symbol
DEFB1
HGNC
Name
defensin beta 1
HGNC
NCBI Gene ID
1672
NCBI Gene
HGNC ID
HGNC:2766
HGNC
Ensembl
ENSG00000164825
NCBI Gene
Aliases
BD1, DEFB-1, DEFB101, HBD-1, HBD1, MGC51822
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P60022Beta-defensin 16815Ensembl, GeneID, HGNC

Source UniProt

Patents103

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443477P60022Espacenet
EP 4650780 A22025-11-193821P60022Espacenet
JP 2025147176 A2025-10-064127P60022Espacenet
US 12409247 B22025-09-0986P60022Espacenet
JP 2025529142 A2025-09-046135P60022Espacenet
US 12371689 B22025-07-296135P60022Espacenet
JP 2025517970 A2025-06-123821P60022Espacenet
JP 2025028160 A2025-02-284127P60022Espacenet
KR 1020250010750 A2025-01-214127P60022Espacenet
US 12186368 B22025-01-0736P60022Espacenet

1 to 10 of 103

See all 103 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,745

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDEFB1 papersNewest fiscal year
P30EY007551Center Core Grant for Vision Research82025
R01DK095491Indole dysbiosis and mucosal inflammation72025
I01BX002182Metabolic Regulation of Mucosal Inflammation62025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition62025
P30CA008748Cancer Center Support Grant52025
P30CA023108Cancer Center Support Grant52025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202852025
R01DK104713Metabolic Regulation of Inflammation by Microbial SCFA52025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias42025
P42ES004705Toxic substances in the environment42025

1 to 10 of 1,745Source NIH's project files

See all 1,745 nih grants

Papers3,189

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The influence of focused ultrasound in the treatment of cervical squamous intraepithelial lesion on vaginal microbiota and cervical immune microenvironment: a prospective observational study.Int J Hyperthermia202642811769PubTator, text miningPubMed
Defensins-thioredoxin crosstalk in innate immunity: A redox switch linking barrier defense, inflammation, and disease.Mol Immunol202642810144PubTator, text miningPubMed
DEFB1 + Cancer Cell-IFI30+ Macrophage Crosstalk Drives Immunosuppressive Niche in Intrahepatic Cholangiocarcinoma.Genomics Proteomics Bioinformatics202642804717PubTator, text miningPubMed
Fragment-Based Discovery of BRD4-BD2 Selective Binders: Biophysical Validation and Structural Insights for Domain-Selective Inhibitor Design.ACS Omega202642798998PubTator, text miningPubMed
Comparative Effects of Pairwise Combinations of Carboplatin, Everolimus, and Astaxanthin on Cell Viability, Migration, and Inflammatory Biomarkers in SKOV3 Ovarian Cancer Cells.Int J Mol Sci202642794426PubTator, text miningPubMed
Biodiversity of NSLAB in Traditional Serbian Cheeses and Stepwise Functional Characterization of Selected Autochthonous Lactobacillus Strains Through Technological, Probiotic and Intestinal Epithelial Interaction Assessment.
Foods202642794004PubTator, text miningPubMed
Avian β-defensin 1 as an antibiotic-sparing supplement for preserving rooster semen quality and fertility during chilled storage.Poult Sci202642736194PubTator, text miningPubMed
Streamlining recombinant peptide and protein production using a pre-configured elastin-like polypeptide expression cassette.PLoS One202642726794PubTator, text miningPubMed
The relationship of peripheral circadian gene mRNAs, antisense lncRNAs, and serum protein levels with chronotype, biological, and social rhythm in euthymic patients with bipolar disorder.Chronobiol Int202642693835PubTator, text miningPubMed
Umbrella Sampling Simulations of Human β Defensin Type 1 and 3 Crossing Model Bacterial Membranes.J Phys Chem B202642691412PubTator, text miningPubMed

1 to 10 of 3,189

See all 3,189 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1672

GET https://conductscience.org/api/genes/v1/1672/patents?page=2