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CFD: complement factor D

1 protein, 87 patents, 2 drugs, 21 trials, 2,588 NIH grants and 5,244 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCFDHGNC
Namecomplement factor DHGNC
NCBI Gene ID1675NCBI Gene
HGNC IDHGNC:2771HGNC
EnsemblENSG00000197766NCBI Gene
AliasesADIPSIN, ADN, DF, PFDNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00746Complement factor D25340Ensembl, GeneID, HGNCUniProt

Patents 87

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442124P00746Espacenet
JP 2026000906 A2026-01-06253P00746Espacenet
EP 4667578 A22025-12-24196P00746Espacenet
EP 4650780 A22025-11-195947P00746Espacenet
EP 4641203 A22025-10-29182P00746Espacenet
JP 2025147176 A2025-10-062680P00746Espacenet
JP 2025131621 A2025-09-09196P00746Espacenet
JP 2025529142 A2025-09-045840P00746Espacenet
US 12371689 B22025-07-295840P00746Espacenet
JP 2025517967 A2025-06-12182P00746Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DANICOPANCHEMBL4250860Complement factor D inhibitorINHIBITORChEMBL
LAMPALIZUMABCHEMBL2109408Complement factor D inhibitorINHIBITORChEMBL

Trials 21

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07413679DANICOPANClinicalTrials.gov
NCT07413250DANICOPANClinicalTrials.gov
NCT06449001DANICOPANPHASE3ClinicalTrials.gov
NCT05982938DANICOPANClinicalTrials.gov
NCT05389449DANICOPANPHASE3ClinicalTrials.gov
NCT05019521DANICOPANPHASE22025-09-05ClinicalTrials.gov
NCT04988035DANICOPANPHASE22023-06-08ClinicalTrials.gov
NCT04469465DANICOPANPHASE32023-07-24ClinicalTrials.gov
NCT04170023DANICOPANPHASE22024-08-09ClinicalTrials.gov
NCT03472885DANICOPANPHASE22021-06-25ClinicalTrials.gov

NIH grants 2588

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant112,025NIH's project files
P30CA016672Cancer Center Support Grant82,025NIH's project files
R01AR051749Complement in the Pathogenesis of Autoimmune Arthritis82,025NIH's project files
P40OD018537Bloomington Drosophila Stock Center at Indiana University72,025NIH's project files
ZIAHL006001Framingham Project/Levy72,025NIH's project files
T32AI007051Immunologic Diseases and Basic Immunology62,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)52,025NIH's project files
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions42,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support42,025NIH's project files
P30EY005722Center Core Grant for Vision Research42,025NIH's project files

Papers 5244

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42780480PubTator, text miningPubMed
42746023PubTator, text miningPubMed
42728482PubTator, text miningPubMed
42649169PubTator, text miningPubMed
42624033PubTator, text miningPubMed
42607545PubTator, text miningPubMed
42585470PubTator, text miningPubMed
42565416PubTator, text miningPubMed
42527038PubTator, text miningPubMed
42509229PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license