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Gene · 170572

HTR3C: 5-hydroxytryptamine receptor 3C

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HTR3C: 5-hydroxytryptamine receptor 3C. Genes, record 170572. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/170572

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Gene

Symbol
HTR3C
HGNC
Name
5-hydroxytryptamine receptor 3C
HGNC
NCBI Gene ID
170572
NCBI Gene
HGNC ID
HGNC:24003
HGNC
Ensembl
ENSG00000178084
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8WXA85-hydroxytryptamine receptor 3C4470Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435769Q8WXA8Espacenet
EP 4650780 A22025-11-195447Q8WXA8Espacenet
EP 4641201 A22025-10-295053Q8WXA8Espacenet
JP 2025529142 A2025-09-042010Q8WXA8Espacenet
US 12371689 B22025-07-292010Q8WXA8Espacenet
JP 2025517969 A2025-06-125053Q8WXA8Espacenet
JP 2025517970 A2025-06-125447Q8WXA8Espacenet
JP 2025062604 A2025-04-14411Q8WXA8Espacenet
US 11446398 B22022-09-20411Q8WXA8Espacenet
US 11400116 B22022-08-025662Q8WXA8Espacenet

1 to 10 of 20

See all 20 patents

Drugs15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
CLOTHIAPINECHEMBL304902Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL
FACINICLINECHEMBL2151439Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
FACINICLINE HYDROCHLORIDECHEMBL5095032Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
MOSAPRIDECHEMBL60889Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
PUMOSETRAGCHEMBL1643880Serotonin 3 (5-HT3) receptor partial agonistPARTIAL AGONISTChEMBL
RAMOSETRONCHEMBL1643895Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
RAMOSETRON HYDROCHLORIDECHEMBL3181841Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL

1 to 10 of 15

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Trials67

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07152184AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06887621AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06585540AMISULPRIDEPHASE3ClinicalTrials.gov
NCT06581302AMISULPRIDEClinicalTrials.gov
NCT06166615RAMOSETRONPHASE2/PHASE3ClinicalTrials.gov
NCT06040944AMISULPRIDEClinicalTrials.gov
NCT05956600AMISULPRIDEClinicalTrials.gov
NCT05347199AMISULPRIDEPHASE1ClinicalTrials.gov
NCT04954365AMISULPRIDEClinicalTrials.gov
NCT04533724AMISULPRIDEEARLY_PHASE1ClinicalTrials.gov

1 to 10 of 67

See all 67 trials

NIH grants118

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTR3C papersNewest fiscal year
K12DA000167Clinician Scientist Training Program (CSTP)12025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)12025
P30CA043703Case Comprehensive Cancer Center Support Grant12025
P30CA076292Moffitt Cancer Center Support Grant12025
P30CA124435Stanford Cancer Institute12025
R01CA241137A microengineered colon cancer-chip designed to investigate tumor-stromal interactions driving cancer progression12025
R01EB023281FreeSurfer Development, Maintenance, and Hardening12025
T32CA090314Behavioral Oncology Education & Career Development12025
T32HG000044Institutional Training Grant in Genome Science12025
U01CA206110Transdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare Study12025

1 to 10 of 118Source NIH's project files

See all 118 nih grants

Papers157

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-Omics and Machine Learning Identify Immune-Linked Gene Signatures for LUAD Stratification.Genes (Basel)202642792990PubTator, text miningPubMed
Integrated Metabolomic and Transcriptomic Analyses Reveal Alterations in the Serotonergic Synapse Pathway and a Robust Diagnostic Model in Ulcerative Colitis.Metabolites202642042908PubTator, text miningPubMed
Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis.Nat Genet202641917433PubTator, text miningPubMed
Neurotransmitter Systems in Alzheimer's Disease.Curr Issues Mol Biol202641899485PubTator, text miningPubMed
Quantifying the fidelity of in vitro human cell culture systems using a biomedical foundation model.Proc Natl Acad Sci U S A202641860964PubTator, text miningPubMed
Transformer-based deep learning enhances discovery in migraine GWAS.Nat Commun202541372126PubTator, text miningPubMed
Impaired Molecular Mechanisms Contributing to Chronic Pain in Patients with Hidradenitis Suppurativa: Exploring Potential Biomarkers and Therapeutic Targets.Int J Mol Sci202539940809PubTator, text miningPubMed
Serotonin Receptors Polymorphisms Are Associated With Cyclic Vomiting Syndrome.Neurogastroenterol Motil202539888244PubTator, text miningPubMed
Genes related to neurotransmitter receptors as potential biomarkers for Alzheimer's disease.Neurosci Lett202438729598PubTator, text miningPubMed
A novel immune-related gene signature for diagnosis and potential immunotherapy of microsatellite stable endometrial carcinoma.Sci Rep202438355782PubTator, text miningPubMed

1 to 10 of 157

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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