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Gene · 171389

NLRP6: NLR family pyrin domain containing 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NLRP6: NLR family pyrin domain containing 6. Genes, record 171389. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/171389

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Gene

Symbol
NLRP6
HGNC
Name
NLR family pyrin domain containing 6
HGNC
NCBI Gene ID
171389
NCBI Gene
HGNC ID
HGNC:22944
HGNC
Ensembl
ENSG00000174885
NCBI Gene
Aliases
AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P59044NACHT, LRR and PYD domains-containing protein 68922Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-294212P59044Espacenet
JP 2025517969 A2025-06-124212P59044Espacenet
JP 2024522216 A2024-06-11102P59044Espacenet
KR 1020240022540 A2024-02-20102P59044Espacenet
US 11564998 B22023-01-315337P59044Espacenet
US 11446398 B22022-09-2057328P59044Espacenet
JP 2022524081 A2022-04-27160299P59044Espacenet
US 10918740 B22021-02-169088P59044Espacenet
US 10869935 B22020-12-229088P59044Espacenet
US 10463751 B22019-11-055337P59044Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants782

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNLRP6 papersNewest fiscal year
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation102025
R01AI124346Innate immune signaling and stress response82025
R01AI029564Molecular and Functional Analysis of Innate Immune Receptors52025
UL1TR001863Yale Clinical and Translational Science Award52025
P30CA016086Cancer Center Support Grant42025
R01AI124491NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing42025
R01AI160179Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases42025
R35CA232109Intracellular Innate Immune Receptors in Cancer Suppression and Immunotherapy42025
R35CA253095Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer42025
P30DK045735Yale Diabetes Research Center32025

1 to 10 of 782Source NIH's project files

See all 782 nih grants

Papers1,410

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ER Stress Regulates HIV Tat and Alcohol-Induced NLRP6 Activation in Astrocytes.CNS Neurosci Ther202642806587PubTator, text miningPubMed
Structural mechanisms for ATP-mediated inhibition of human NLRP6 inflammasome.Nat Struct Mol Biol202642711541PubTator, text miningPubMed
Expression, Regulation and Therapeutic Implications of Nod-Like Receptors in Endodontics: A Narrative Review.Int Endod J202642677679PubTator, text miningPubMed
NLRP6 as a candidate segmental barrier to carcinogenesis in the human gut: a hypothesis.Front Immunol202642620674PubTator, text miningPubMed
GSDMB as a Therapeutic and Prognostic Target in Clear Cell Renal Cell Carcinoma: Insights From Pyroptosis-Related Gene Analysis.Front Biosci (Landmark Ed)202642530271PubTator, text miningPubMed
Defining the therapeutic window of NLRP6 modulation in graft-versus-host disease. Comment on: "NLRP6 regulates donor T cell activation and acute graft-versus-host disease via ZAP-70-Erk pathway".Haematologica202642489079PubTator, text miningPubMed
Inflammasomes in Intestinal Inflammation: Guardians of Mucosal Homeostasis, Amplifiers of Disease, and Targets for Intervention.Intern Med202642402409PubTator, text miningPubMed
Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity.Nat Commun202642336837PubTator, text miningPubMed
Supramolecular Assemblies Drive Activation of Inflammasomes.Adv Exp Med Biol202642334537PubTator, text miningPubMed
NLR inflammasome pathways: key targets for pathogenesis and therapy of metabolic diseases.Front Immunol202642292355PubTator, text miningPubMed

1 to 10 of 1,410

See all 1,410 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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