Gene · 171389
NLRP6: NLR family pyrin domain containing 6
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NLRP6: NLR family pyrin domain containing 6. Genes, record 171389. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/171389
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P59044 | NACHT, LRR and PYD domains-containing protein 6 | 892 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 4212 | P59044 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4212 | P59044 | Espacenet |
| JP 2024522216 A | 2024-06-11 | 102 | P59044 | Espacenet |
| KR 1020240022540 A | 2024-02-20 | 102 | P59044 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5337 | P59044 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 57328 | P59044 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 160299 | P59044 | Espacenet |
| US 10918740 B2 | 2021-02-16 | 9088 | P59044 | Espacenet |
| US 10869935 B2 | 2020-12-22 | 9088 | P59044 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 5337 | P59044 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants782
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NLRP6 papers | Newest fiscal year |
|---|---|---|---|
| R37AI101935 | Inflammatory Caspases in Innate Immunity and Inflammation | 10 | 2025 |
| R01AI124346 | Innate immune signaling and stress response | 8 | 2025 |
| R01AI029564 | Molecular and Functional Analysis of Innate Immune Receptors | 5 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 4 | 2025 |
| R01AI124491 | NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing | 4 | 2025 |
| R01AI160179 | Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases | 4 | 2025 |
| R35CA232109 | Intracellular Innate Immune Receptors in Cancer Suppression and Immunotherapy | 4 | 2025 |
| R35CA253095 | Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer | 4 | 2025 |
| P30DK045735 | Yale Diabetes Research Center | 3 | 2025 |
1 to 10 of 782Source NIH's project files
See all 782 nih grantsPapers1,410
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| ER Stress Regulates HIV Tat and Alcohol-Induced NLRP6 Activation in Astrocytes. | CNS Neurosci Ther | 2026 | 42806587 | PubTator, text mining | PubMed |
| Structural mechanisms for ATP-mediated inhibition of human NLRP6 inflammasome. | Nat Struct Mol Biol | 2026 | 42711541 | PubTator, text mining | PubMed |
| Expression, Regulation and Therapeutic Implications of Nod-Like Receptors in Endodontics: A Narrative Review. | Int Endod J | 2026 | 42677679 | PubTator, text mining | PubMed |
| NLRP6 as a candidate segmental barrier to carcinogenesis in the human gut: a hypothesis. | Front Immunol | 2026 | 42620674 | PubTator, text mining | PubMed |
| GSDMB as a Therapeutic and Prognostic Target in Clear Cell Renal Cell Carcinoma: Insights From Pyroptosis-Related Gene Analysis. | Front Biosci (Landmark Ed) | 2026 | 42530271 | PubTator, text mining | PubMed |
| Defining the therapeutic window of NLRP6 modulation in graft-versus-host disease. Comment on: "NLRP6 regulates donor T cell activation and acute graft-versus-host disease via ZAP-70-Erk pathway". | Haematologica | 2026 | 42489079 | PubTator, text mining | PubMed |
| Inflammasomes in Intestinal Inflammation: Guardians of Mucosal Homeostasis, Amplifiers of Disease, and Targets for Intervention. | Intern Med | 2026 | 42402409 | PubTator, text mining | PubMed |
| Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity. | Nat Commun | 2026 | 42336837 | PubTator, text mining | PubMed |
| Supramolecular Assemblies Drive Activation of Inflammasomes. | Adv Exp Med Biol | 2026 | 42334537 | PubTator, text mining | PubMed |
| NLR inflammasome pathways: key targets for pathogenesis and therapy of metabolic diseases. | Front Immunol | 2026 | 42292355 | PubTator, text mining | PubMed |
1 to 10 of 1,410
See all 1,410 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/171389
GET https://conductscience.org/api/genes/v1/171389/patents