Gene · 1718
DHCR24: 24-dehydrocholesterol reductase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DHCR24: 24-dehydrocholesterol reductase. Genes, record 1718. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1718
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15392 | Delta(24)-sterol reductase | 516 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents82
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 35684 | Q15392 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8923 | Q15392 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 509 | Q15392 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1254 | Q15392 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1254 | Q15392 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8923 | Q15392 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 122 | Q15392 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 509 | Q15392 | Espacenet |
| JP 2024112982 A | 2024-08-21 | 4454 | Q15392 | Espacenet |
| JP 2022184996 A | 2022-12-13 | 4454 | Q15392 | Espacenet |
1 to 10 of 82
See all 82 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| TRIPARANOL | CHEMBL187709 | Delta(24)-sterol reductase inhibitor | INHIBITOR |
Source ChEMBL
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,096
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DHCR24 papers | Newest fiscal year |
|---|---|---|---|
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 5 | 2025 |
| ZIAHL006001 | Framingham Project/Levy | 5 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 4 | 2025 |
| P30CA093373 | Cancer Center Support Grant P30 | 4 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 4 | 2025 |
| P30ES023515 | Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS) | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 3 | 2025 |
1 to 10 of 1,096Source NIH's project files
See all 1,096 nih grantsPapers1,464
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Exploring the role of statin interventions on cognitive function by Mendelian randomization study. | J Alzheimers Dis Rep | 2026 | 42818896 | PubTator, text mining | PubMed |
| DHCR24 promotes endometrial carcinoma progression and is associated with cellular senescence regulation. | Med Oncol | 2026 | 42742784 | PubTator, text mining | PubMed |
| DHCR24 regulates endothelial senescence through the SPHK2/SPNS2-S1P axis. | Biogerontology | 2026 | 42704384 | PubTator, text mining | PubMed |
| DHCR24+ tumor epithelial cells drive cisplatin resistance in bladder cancer by enhancing cholesterol metabolism to activate lipid raft-associated MAPK signaling. | Oncogene | 2026 | 42668326 | PubTator, text mining | PubMed |
| RHD genotyping of serological weak D phenotypes among blood donors in Eastern Iran. | Transfus Apher Sci | 2026 | 42497722 | PubTator, text mining | PubMed |
| Cholesterol metabolic rewiring shapes immune remodeling across hepatocarcinogenesis. | Front Immunol | 2026 | 42488674 | PubTator, text mining | PubMed |
| Comprehensive Spatial Transcriptomic Profiling of Cribriform, Intraductal, Atypical Intraductal Proliferation, and Ductal Adenocarcinoma of the Prostate. | Lab Invest | 2026 | 42468875 | PubTator, text mining | PubMed |
| Sterol biosynthesis, brain development, and disease. | J Clin Invest | 2026 | 42454491 | PubTator, text mining | PubMed |
| The elevated clock genes involved in regulating the hormone secretion and follicular development during the laying period of geese. | Anim Reprod Sci | 2026 | 42287886 | PubTator, text mining | PubMed |
| Blood DNA Methylation Patterns Across Carotid, Coronary, and Peripheral Atherosclerosis: A Comparative Analysis in 2 Prospective Cohorts. | J Am Coll Cardiol | 2026 | 42233926 | PubTator, text mining | PubMed |
1 to 10 of 1,464
See all 1,464 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1718
GET https://conductscience.org/api/genes/v1/1718/patents?page=2