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Gene · 1718

DHCR24: 24-dehydrocholesterol reductase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DHCR24: 24-dehydrocholesterol reductase. Genes, record 1718. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1718

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Gene

Symbol
DHCR24
HGNC
Name
24-dehydrocholesterol reductase
HGNC
NCBI Gene ID
1718
NCBI Gene
HGNC ID
HGNC:2859
HGNC
Ensembl
ENSG00000116133
NCBI Gene
Aliases
DCE, KIAA0018, Nbla03646, SELADIN1, seladin-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15392Delta(24)-sterol reductase5160Ensembl, GeneID, HGNC

Source UniProt

Patents82

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435684Q15392Espacenet
EP 4650780 A22025-11-198923Q15392Espacenet
EP 4641202 A22025-10-29509Q15392Espacenet
JP 2025529142 A2025-09-041254Q15392Espacenet
US 12371689 B22025-07-291254Q15392Espacenet
JP 2025517970 A2025-06-128923Q15392Espacenet
JP 2025062604 A2025-04-14122Q15392Espacenet
KR 1020250017231 A2025-02-04509Q15392Espacenet
JP 2024112982 A2024-08-214454Q15392Espacenet
JP 2022184996 A2022-12-134454Q15392Espacenet

1 to 10 of 82

See all 82 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
TRIPARANOLCHEMBL187709Delta(24)-sterol reductase inhibitorINHIBITOR

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,096

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDHCR24 papersNewest fiscal year
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)52025
ZIAHL006001Framingham Project/Levy52025
P30CA006927Comprehensive Cancer Center Program at Fox Chase42025
P30CA093373Cancer Center Support Grant P3042025
P30ES005605Environmental Health Sciences Research Center42025
P30ES023515Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS)42025
P30CA008748Cancer Center Support Grant32025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30DK056341Washington University Nutrition Obesity Research Center32025

1 to 10 of 1,096Source NIH's project files

See all 1,096 nih grants

Papers1,464

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exploring the role of statin interventions on cognitive function by Mendelian randomization study.J Alzheimers Dis Rep202642818896PubTator, text miningPubMed
DHCR24 promotes endometrial carcinoma progression and is associated with cellular senescence regulation.Med Oncol202642742784PubTator, text miningPubMed
DHCR24 regulates endothelial senescence through the SPHK2/SPNS2-S1P axis.Biogerontology202642704384PubTator, text miningPubMed
DHCR24+ tumor epithelial cells drive cisplatin resistance in bladder cancer by enhancing cholesterol metabolism to activate lipid raft-associated MAPK signaling.Oncogene202642668326PubTator, text miningPubMed
RHD genotyping of serological weak D phenotypes among blood donors in Eastern Iran.Transfus Apher Sci202642497722PubTator, text miningPubMed
Cholesterol metabolic rewiring shapes immune remodeling across hepatocarcinogenesis.Front Immunol202642488674PubTator, text miningPubMed
Comprehensive Spatial Transcriptomic Profiling of Cribriform, Intraductal, Atypical Intraductal Proliferation, and Ductal Adenocarcinoma of the Prostate.Lab Invest202642468875PubTator, text miningPubMed
Sterol biosynthesis, brain development, and disease.J Clin Invest202642454491PubTator, text miningPubMed
The elevated clock genes involved in regulating the hormone secretion and follicular development during the laying period of geese.Anim Reprod Sci202642287886PubTator, text miningPubMed
Blood DNA Methylation Patterns Across Carotid, Coronary, and Peripheral Atherosclerosis: A Comparative Analysis in 2 Prospective Cohorts.J Am Coll Cardiol202642233926PubTator, text miningPubMed

1 to 10 of 1,464

See all 1,464 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1718

GET https://conductscience.org/api/genes/v1/1718/patents?page=2